Reactome | Activated MET recruits GRB2-1:SOS1

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Activated MET recruits GRB2-1:SOS1 Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8851806] Orlic-Milacic, Marija, 2016-01-11
dbId	8851804
displayName	Activated MET recruits GRB2-1:SOS1
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8851805] MET activates RAS signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Homo sapiens
input	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-HSA-6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6806997] A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family [LiteratureReference:8851815] Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase [LiteratureReference:8851816] DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells [LiteratureReference:8851812] Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2 [LiteratureReference:8931722] Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated MET recruits GRB2-1:SOS1
orthologousEvent	[Reaction:R-GGA-8851804] Activated MET recruits GRB2-1:SOS1 - Gallus gallus [Reaction:R-XTR-8851804] Activated MET recruits GRB2-1:SOS1 - Xenopus tropicalis [Reaction:R-DRE-8851804] Activated MET recruits GRB2-1:SOS1 - Danio rerio [Reaction:R-SSC-8851804] Activated MET recruits GRB2-1:SOS1 - Sus scrofa [Reaction:R-BTA-8851804] Activated MET recruits GRB2-1:SOS1 - Bos taurus [Reaction:R-CFA-8851804] Activated MET recruits GRB2-1:SOS1 - Canis familiaris [Reaction:R-RNO-8851804] Activated MET recruits GRB2-1:SOS1 - Rattus norvegicus [Reaction:R-MMU-8851804] Activated MET recruits GRB2-1:SOS1 - Mus musculus
output	[Complex:R-HSA-8851807] HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-6806974] MET dimers autophosphorylate - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8851847] Negative regulation by 'HGF:p-4Y MET dimer:MUC20 [plasma membrane]'
regulationReference	[RegulationReference:9642159] Negative regulation by 'HGF:p-4Y MET dimer:MUC20 [plasma membrane]' MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8851804
summation	[Summation:8851809] Phosphorylated tyrosine residue Y1356 of MET receptor create...

Referrals

(hasEvent)	[Pathway:R-HSA-8851805] MET activates RAS signaling
(precedingEvent)	[Reaction:R-HSA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1

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