Reactome | GRB2-1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

GRB2-1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9029097] GRB2-1:p-Y-VAV1 [cytosol] - Homo sapiens [Complex:R-HSA-9680372] GRB2:GAB3 [cytosol] - Homo sapiens [Complex:R-HSA-8851921] HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9703442] Phosphorylated FLT3 fusions bind GRB2 - Homo sapiens [Reaction:R-HSA-109813] GRB2-1 binds SOS1 - Homo sapiens [Reaction:R-HSA-204871] Interaction of Tie2 and Grb2 - Homo sapiens [Reaction:R-HSA-1295613] SPRY2 binds GRB2 - Homo sapiens [Reaction:R-HSA-354087] Recruitment of GRB2 to p-PTK2 - Homo sapiens [BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 - Homo sapiens [Reaction:R-HSA-391153] p-4Y-SIRPA:CD47 binds GRB2-1 - Homo sapiens [Reaction:R-HSA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Homo sapiens [Reaction:R-HSA-914022] SHP2 can recruit GRB2 - Homo sapiens [Reaction:R-HSA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Homo sapiens [Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Homo sapiens [Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Homo sapiens [Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Homo sapiens [Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Homo sapiens [Reaction:R-HSA-177920] Binding of GRB2 to GAB1 - Homo sapiens [Reaction:R-HSA-392051] Recruitment of Grb2 to pFAK:NCAM1 - Homo sapiens [Reaction:R-HSA-9604738] Active FLT3 dimer binds GRB2 - Homo sapiens [Reaction:R-HSA-388814] Grb2 binds CD28 - Homo sapiens [Reaction:R-HSA-183052] CBL binds to GRB2 - Homo sapiens [Reaction:R-HSA-389919] Grb2 binds pBTLA - Homo sapiens [Reaction:R-HSA-8851919] Activated MET binds GAB1 and GRB2 - Homo sapiens [Reaction:R-HSA-9606887] p-CD19:VAV binds PI3K and GRB2 - Homo sapiens
created	[InstanceEdit:74677] Schmidt, EE, 2003-08-20 08:52:29
dbId	74686
displayName	GRB2-1 [cytosol]
endCoordinate	217
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-74686] Grb2 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-74686] Grb2 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-74686] GRB2 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-74686] GRB2 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-74686] GRB2 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-74686] grb2a [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-DRE-74686-2] grb2b [cytosol] - Danio rerio [DefinedSet:R-DRE-74686-3] Homologues of GRB2-1 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-74686] grb2 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-74686] GRB2 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-74686] drk [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-74686] sem-5 [cytosol] - Caenorhabditis elegans
maxDepth	1
memberOf	[DefinedSet:R-HSA-2197679] SH3 domain proteins [cytosol] - Homo sapiens [CandidateSet:R-HSA-9019558] RHOU effectors [cytosol] - Homo sapiens
modified	[InstanceEdit:8876264] Orlic-Milacic, Marija, 2016-06-10
name	GRB2-1 GRB2 isoform 1 Growth factor receptor-bound protein 2 SH2/SH3 adapter GRB2 ASH protein Ash-L
producedByEvent	[Reaction:R-HSA-1549564] PPTN11 dephosphorylates SPRY2 - Homo sapiens
referenceEntity	[ReferenceIsoform:uniprot:P62993-1] UniProt:P62993-1 GRB2
referenceType	ReferenceIsoform
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-74686
startCoordinate	1
updateTrackers	[UpdateTracker:9883239] Update Tracker - [EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] - v45:[modifyName] [UpdateTracker:9871046] Update Tracker - [EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] - v39:[modifyEndCoordinate]

Referrals

(hasComponent)	[Complex:R-HSA-9029097] GRB2-1:p-Y-VAV1 [cytosol] [Complex:R-HSA-9029096] GRB2-1:VAV1 [cytosol] [Complex:R-HSA-9680366] GRB2-1:p-Y-GAB3 [cytosol] [Complex:R-HSA-9680372] GRB2:GAB3 [cytosol] [Complex:R-HSA-9703378] p-Y FLT3 fusion dimers:GRB2 [cytosol] [Complex:R-HSA-8935905] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] [Complex:R-HSA-8867037] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] [Complex:R-HSA-354113] GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] [Complex:R-HSA-8854978] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] [Complex:R-HSA-8854983] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] [Complex:R-HSA-391112] p-Y428,Y452,Y469,Y495-SIRPA:CD47:GRB2-1 [plasma membrane] [Complex:R-HSA-8876351] p-Y-CBL:GRB2 [cytosol] [Complex:R-HSA-8851921] HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] [Complex:R-HSA-1433549] GRB2:p-SHP2:p-KIT complex [plasma membrane] [Complex:R-HSA-914028] SHP2:GRB2 [cytosol] [Complex:R-HSA-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] [Complex:R-HSA-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-HSA-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-HSA-913411] Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] [Complex:R-HSA-912522] GRB2:GAB2 [cytosol] [Complex:R-HSA-179849] GRB2:GAB1 [cytosol] [Complex:R-HSA-180304] GRB2:Phospho-GAB1 [cytosol] [Complex:R-HSA-9604756] Active FLT3: GRB2 [plasma membrane] [Complex:R-HSA-8851942] HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-HSA-204865] Grb2 bound to Tie2 [plasma membrane] [Complex:R-HSA-392044] pFAK:Grb2:Sos [cytosol] [Complex:R-HSA-983692] BLNK:GRB2:SOS1:CIN85 [cytosol] [Complex:R-NUL-1250499] GRB2:Sos1 [cytosol] [Complex:R-HSA-392043] pFAK:Grb2 [cytosol] [Complex:R-HSA-109801] GRB2-1:p-4S-SOS1 [cytosol] [Complex:R-HSA-388786] CD28:Grb2 [plasma membrane] [Complex:R-HSA-180511] GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] [Complex:R-HSA-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [Complex:R-HSA-182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] [Complex:R-HSA-182910] CBL:GRB2 [cytosol] [Complex:R-HSA-182964] p-Y371-CBL:GRB2 [cytosol] [Complex:R-HSA-1295625] PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] [Complex:R-HSA-190399] GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] [Complex:R-HSA-389921] GRB2:pBTLA:HVEM [plasma membrane] [Complex:R-HSA-912528] GRB2:p-Y-GAB2 [cytosol]
(input)	[Reaction:R-HSA-9703442] Phosphorylated FLT3 fusions bind GRB2 [Reaction:R-HSA-354087] Recruitment of GRB2 to p-PTK2 [BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 [Reaction:R-HSA-391153] p-4Y-SIRPA:CD47 binds GRB2-1 [Reaction:R-HSA-8851919] Activated MET binds GAB1 and GRB2 [Reaction:R-HSA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 [Reaction:R-HSA-914022] SHP2 can recruit GRB2 [Reaction:R-HSA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 [Reaction:R-HSA-177920] Binding of GRB2 to GAB1 [Reaction:R-HSA-109813] GRB2-1 binds SOS1 [Reaction:R-HSA-204871] Interaction of Tie2 and Grb2 [Reaction:R-HSA-392051] Recruitment of Grb2 to pFAK:NCAM1 [Reaction:R-HSA-9604738] Active FLT3 dimer binds GRB2 [Reaction:R-HSA-9606887] p-CD19:VAV binds PI3K and GRB2 [Reaction:R-HSA-388814] Grb2 binds CD28 [Reaction:R-HSA-183052] CBL binds to GRB2 [Reaction:R-HSA-1295613] SPRY2 binds GRB2 [Reaction:R-HSA-389919] Grb2 binds pBTLA
(output)	[Reaction:R-HSA-1549564] PPTN11 dephosphorylates SPRY2
(hasMember)	[CandidateSet:R-HSA-9019558] RHOU effectors [cytosol] [DefinedSet:R-HSA-2197679] SH3 domain proteins [cytosol]
(requiredInputComponent)	[Reaction:R-HSA-354165] Interaction of SOS with GRB2 bound to FADK1
(updatedInstance)	[UpdateTracker:9883239] Update Tracker - [EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] - v45:[modifyName] [UpdateTracker:9871046] Update Tracker - [EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] - v39:[modifyEndCoordinate]

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