Reactome | p-KIT mutants:GRB2:SOS [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:9670404] guanyl-nucleotide exchange factor activity of p-KIT mutants:GRB2:SOS [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9670364] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670365
disease	[Disease:1500689] cancer
displayName	p-KIT mutants:GRB2:SOS [plasma membrane]
hasComponent	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [DefinedSet:R-HSA-9670355] p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	5
modified	[InstanceEdit:9686493] Rothfels, Karen, 2020-05-04
name	p-KIT mutants:GRB2:SOS
producedByEvent	[Reaction:R-HSA-9670428] KIT mutants bind GRB2-SOS - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9670365

(output)	[Reaction:R-HSA-9670428] KIT mutants bind GRB2-SOS
(diseaseEntity)	[EntityFunctionalStatus:9670400] gain_of_function of p-KIT mutants:GRB2:SOS [plasma membrane]
(physicalEntity)	[CatalystActivity:9670404] guanyl-nucleotide exchange factor activity of p-KIT mutants:GRB2:SOS [plasma membrane]

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