Reactome | FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:5655231] guanyl-nucleotide exchange factor activity of FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
dbId	5655307
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
hasComponent	[Complex:R-HSA-5655238] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
modified	[InstanceEdit:9753865] Rothfels, Karen, 2021-09-15
name	FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1
producedByEvent	[Reaction:R-HSA-5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5655307

(diseaseEntity)	[EntityFunctionalStatus:5655261] gain_of_function of FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(physicalEntity)	[CatalystActivity:5655231] guanyl-nucleotide exchange factor activity of FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(output)	[Reaction:R-HSA-5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1

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