Reactome | GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR

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GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177936
diseaseReaction	[Reaction:R-HSA-5637798] Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex - Homo sapiens [Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens
displayName	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling - Homo sapiens
figure	[Figure:179443] /figures/phos_shc_binds_grb2sos.jpg
followingEvent	[Reaction:R-HSA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[Complex:R-HSA-180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
orthologousEvent	[Reaction:R-DME-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Drosophila melanogaster [Reaction:R-GGA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Gallus gallus [Reaction:R-XTR-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Xenopus tropicalis [Reaction:R-SSC-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Sus scrofa [Reaction:R-BTA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Bos taurus [Reaction:R-CFA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Canis familiaris [Reaction:R-RNO-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Rattus norvegicus [Reaction:R-MMU-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Mus musculus
output	[Complex:R-HSA-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-177933] SHC1 phosphorylation by phosphorylated EGFR - Homo sapiens [Reaction:R-HSA-109813] GRB2-1 binds SOS1 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177936
summation	[Summation:188535] The tyrosine sites on SHC1 become possible binding sites for...
updateTrackers	[UpdateTracker:9789510] Update Tracker - [Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789510] Update Tracker - [Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - v38:[modifyText]
(normalReaction)	[Reaction:R-HSA-5637798] Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex [Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
(hasEvent)	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling
(precedingEvent)	[Reaction:R-HSA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange