Reactome | p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:9665452] guanyl-nucleotide exchange factor activity of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9665447] Orlic-Milacic, Marija, 2019-10-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665449
disease	[Disease:1500689] cancer
displayName	p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
hasComponent	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-HSA-9665380] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
inDisease	true
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
isChimeric	false
maxDepth	4
name	p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1
producedByEvent	[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9665449

(diseaseEntity)	[EntityFunctionalStatus:9665450] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
(physicalEntity)	[CatalystActivity:9665452] guanyl-nucleotide exchange factor activity of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
(output)	[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR

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