Reactome | GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]

Schema > Complex > Entries

GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:1250381] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1250386] Orlic-Milacic, Marija, 2011-04-18
dbId	1250382
displayName	GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
hasComponent	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-HSA-1250343] p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Mus musculus [Complex:R-RNO-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Canis familiaris [Complex:R-BTA-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Bos taurus [Complex:R-SSC-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Sus scrofa [Complex:R-DRE-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Danio rerio [Complex:R-XTR-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Gallus gallus [Complex:R-DME-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Drosophila melanogaster
isChimeric	false
maxDepth	9
memberOf	[DefinedSet:R-HSA-5672601] RAS GEFs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:2213009] Matthews, L, 2012-04-27
name	GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4
producedByEvent	[Reaction:R-HSA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1250382
updateTrackers	[UpdateTracker:9872055] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9888453] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v46:[updateContainedComponent] [UpdateTracker:9892416] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v53:[updateContainedComponent] [UpdateTracker:9898279] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v63:[updateContainedComponent] [UpdateTracker:9873052] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v42:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9872055] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9888453] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v46:[updateContainedComponent] [UpdateTracker:9892416] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v53:[updateContainedComponent] [UpdateTracker:9898279] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v63:[updateContainedComponent] [UpdateTracker:9873052] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v42:[updateContainedComponent]
(output)	[Reaction:R-HSA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
(physicalEntity)	[CatalystActivity:1250381] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-5672601] RAS GEFs [plasma membrane]

© 2026 Reactome

Cite Us!