Reactome | CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1

Schema > Reaction > Entries

authored	[InstanceEdit:9733318] May, Bruce, 2021-05-25
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9733322] May, Bruce, 2021-06-03
dbId	9733330
displayName	CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1
edited	[InstanceEdit:9733318] May, Bruce, 2021-05-25
eventOf	[Pathway:R-HSA-9680350] Signaling by CSF1 (M-CSF) in myeloid cells - Homo sapiens
followingEvent	[Reaction:R-HSA-9680385] CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS - Homo sapiens
inferredFrom	[Reaction:R-MMU-9763903] Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1 - Mus musculus
input	[Complex:R-HSA-9818000] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1
output	[Complex:R-HSA-9733324] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9818010] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9733330
summation	[Summation:9766325] After an initial wave of phosphorylation of CSF1R, the stabl...

(precedingEvent)	[Reaction:R-HSA-9680385] CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS
(hasEvent)	[Pathway:R-HSA-9680350] Signaling by CSF1 (M-CSF) in myeloid cells
(inferredTo)	[Reaction:R-MMU-9763903] Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1

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