Reactome | 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1

Schema > Reaction > Entries

2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8854904] Jupe, Steve, 2016-01-29
dbId	8854899
displayName	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[Complex:R-HSA-8854160] 2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8853733] Grb2 binding to the different isoforms of Ret tyrosine kinase [LiteratureReference:8854366] Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
orthologousEvent	[Reaction:R-GGA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Gallus gallus [Reaction:R-DRE-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Danio rerio [Reaction:R-SSC-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Sus scrofa [Reaction:R-BTA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Bos taurus [Reaction:R-CFA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Canis familiaris [Reaction:R-RNO-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Rattus norvegicus [Reaction:R-MMU-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Mus musculus
output	[Complex:R-HSA-8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8853792] RET tyrosine phosphorylation - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854899
summation	[Summation:8854911] RET has been shown to bind GRB2 directly, via Tyrosine-1096 ...

Referrals

(hasEvent)	[Pathway:R-HSA-8853659] RET signaling
(precedingEvent)	[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange

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