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p-S407,Y641-STAT6 [cytosol]
Stable Identifier
R-HSA-3249376
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Signal transducer and activator of transcription 6, STAT6_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
STAT6-mediated induction of chemokines (Homo sapiens)
p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)
p-S407,Y641-STAT6 dimer [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 is dimerized (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 dimer [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42226 STAT6
Gene Names
STAT6
Chain
initiator methionine:, chain:2-847
Reference Genes
BioGPS Gene:6778 STAT6
COSMIC (genes):STAT6 STAT6
CTD Gene:6778 STAT6
dbSNP Gene:6778 STAT6
ENSEMBL:ENSG00000166888 STAT6
HGNC:11368 STAT6
KEGG:hsa:6778 STAT6
Monarch:6778 STAT6
NCBI Gene:6778 STAT6
OMIM:601512 STAT6
UCSC:P42226 STAT6
Reference Transcript
RefSeq:NM_001178080.1 STAT6
RefSeq:NM_001178078.1 STAT6
RefSeq:NM_003153.4 STAT6
RefSeq:XM_006719575.2 STAT6
RefSeq:NM_001178079.1 STAT6
Other Identifiers
11742723_a_at
11742724_x_at
11746850_a_at
11753889_a_at
16766420
201331_PM_s_at
201331_s_at
201332_PM_s_at
201332_s_at
3458338
3458339
3458340
3458341
3458342
3458343
3458344
3458345
3458346
3458347
3458348
3458349
3458350
3458351
3458352
3458353
3458354
3458355
3458356
3458357
3458358
3458359
3458360
3458361
3458362
3458363
3458364
3458365
3458366
3458367
3458368
3458369
3458370
3458371
3458372
3458374
3458375
41222_at
6778
7964360
845_at
A_23_P47879
GE79254
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001223
GO:0001228
GO:0002296
GO:0002376
GO:0002829
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006310
GO:0006355
GO:0006357
GO:0006952
GO:0007165
GO:0007166
GO:0007259
GO:0010467
GO:0019221
GO:0019903
GO:0033598
GO:0034097
GO:0035771
GO:0042127
GO:0042802
GO:0043226
GO:0043434
GO:0043565
GO:0045944
GO:0048289
GO:0048295
GO:0060397
GO:0060443
GO:0070301
GO:0070666
GO:0090575
GO:0120162
GO:0140110
GO:1902170
HMNXSV003026057
ILMN_1763198
PH_hs_0036005
TC12001620.hg
TC12002913.hg
U16031_at
g13436385_3p_s_at
g4507258_3p_s_at
Participates
as a component of
p-S407,Y641-STAT6 dimer [cytosol] (Homo sapiens)
as an input of
p-S407,Y641-STAT6 is dimerized (Homo sapiens)
as an output of
p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)
Other forms of this molecule
p-Y641-STAT6 [cytosol]
p-Y641-STAT6 [nucleoplasm]
STAT6 [cytosol]
p-S407-STAT6 [cytosol]
p-S407,Y641-STAT6 [nucleoplasm]
Inferred To
phospho-dstD [cytosol]
(Dictyostelium discoideum)
phospho-STAT6 [cytosol]
(Bos taurus)
phospho-STAT6 [cytosol]
(Canis familiaris)
phospho-STAT6 [cytosol]
(Sus scrofa)
phospho-sta-2 [cytosol]
(Caenorhabditis elegans)
phospho-sta-1 [cytosol]
(Caenorhabditis elegans)
phospho-stat5b [cytosol]
(Danio rerio)
phospho-dstB [cytosol]
(Dictyostelium discoideum)
phospho-dstC [cytosol]
(Dictyostelium discoideum)
phospho-stat6 [cytosol]
(Danio rerio)
phospho-stat6 [cytosol]
(Xenopus tropicalis)
phospho-p-S407,Y641-STAT6 [cytosol]
(Caenorhabditis elegans)
phospho-p-S407,Y641-STAT6 [cytosol]
(Dictyostelium discoideum)
phospho-stat5a [cytosol]
(Danio rerio)
phospho-Stat92E [cytosol]
(Drosophila melanogaster)
phospho-dstA [cytosol]
(Dictyostelium discoideum)
phospho-Stat6 [cytosol]
(Mus musculus)
phospho-Stat6 [cytosol]
(Rattus norvegicus)
Homologues of p-S407,Y641-STAT6 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S407,Y641-STAT6 [cytosol]
(Danio rerio)
Homologues of p-S407,Y641-STAT6 [cytosol]
(Dictyostelium discoideum)
Modified Residues
Name
O-phospho-L-serine at 407
Coordinate
407
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 641
Coordinate
641
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003144.3
,
NP_001171550.1
,
NP_001171551.1
,
NP_001171549.1
,
XP_006719638.1
Guide to Pharmacology - Targets
2993
OpenTargets
ENSG00000166888
ENSEMBL
ENST00000454075
,
ENST00000300134
,
ENSP00000451742
,
ENSP00000401486
,
ENSP00000300134
,
ENST00000543873
,
ENSP00000444530
,
ENST00000537215
,
ENSP00000438451
,
ENST00000538913
,
ENSP00000445409
,
ENST00000556155
ZINC - Substances
STAT6_HUMAN
ZINC target
P42226
PRO
P42226
GlyGen
P42226
PDB
1OJ5
,
5NWM
,
4Y5W
,
5NWX
,
4Y5U
,
5D39
HPA
ENSG00000166888-STAT6
Pharos - Targets
P42226
Orphanet
STAT6
ZINC - Predictions - Purchasable
STAT6_HUMAN
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24394 IL4R
2
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
IL4R [plasma membrane]
(R-HSA-449670)
0.643
4
UniProt:Q86WV6 STING1
5
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
0.631
12
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.577
7
UniProt:Q13287 NMI
1
NMI [cytosol]
(R-HSA-9731022)
0.573
2
UniProt:P0DTD1-PRO_0000449627 REP
0.547
2
UniProt:P42226 STAT6
6
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
STAT6 [cytosol]
(R-HSA-629625)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
0.524
2
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.462
3
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