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p-S407,Y641-STAT6
Stable Identifier
R-HSA-3249376
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Signal transducer and activator of transcription 6, STAT6_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
STAT6-mediated induction of chemokines (Homo sapiens)
p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)
p-S407,Y641-STAT6 dimer [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 is dimerized (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 dimer [cytosol] (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)
p-S407,Y641-STAT6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42226 STAT6
Gene Names
STAT6
Chain
initiator methionine:1, chain:2-847
Reference Genes
BioGPS Gene:6778 STAT6
COSMIC (genes):STAT6 STAT6
CTD Gene:6778 STAT6
dbSNP Gene:6778 STAT6
ENSEMBL:ENSG00000166888 STAT6
HGNC:11368 STAT6
KEGG Gene (Homo sapiens):hsa:6778 STAT6
Monarch:6778 STAT6
NCBI Gene:6778 STAT6
OMIM:601512 STAT6
UCSC:P42226 STAT6
Reference Transcript
RefSeq:NM_001178080.1 STAT6
RefSeq:XM_006719575.2 STAT6
RefSeq:NM_003153.4 STAT6
RefSeq:NM_001178079.1 STAT6
RefSeq:NM_001178078.1 STAT6
Other Identifiers
0006180441
11742723_a_at
11742724_x_at
11746850_a_at
11753889_a_at
16766420
1861
1OJ5
201331_s_at
201332_s_at
41222_at
4Y5U
4Y5W
5D39
6778
7964360
845_at
A_23_P47879
AAA57193
AAC67525
AAH75852
AAL06595
AB103089
AC023237
AF067572
AF067573
AF067575
AF417842
AK290431
AK316142
BAD89432
BAF83120
BAH14513
BC075852
CCDS53804
CCDS8931
ENSG00000166888
ENSP00000300134
ENSP00000401486
ENSP00000438451
ENSP00000444530
ENSP00000445409
ENSP00000451742
ENST00000300134
ENST00000454075
ENST00000537215
ENST00000538913
ENST00000543873
ENST00000556155
EntrezGene:6778
g13436385_3p_s_at
g4507258_3p_s_at
GE79254
GO:0000122
GO:0000228
GO:0000790
GO:0000977
GO:0000979
GO:0001071
GO:0001228
GO:0002296
GO:0002376
GO:0002829
GO:0003674
GO:0003677
GO:0003700
GO:0004871
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006259
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006950
GO:0007165
GO:0008150
GO:0008283
GO:0009058
GO:0019221
GO:0019899
GO:0019903
GO:0030154
GO:0031965
GO:0032481
GO:0033598
GO:0034097
GO:0034641
GO:0035771
GO:0042127
GO:0042802
GO:0043226
GO:0043565
GO:0045121
GO:0045944
GO:0048295
GO:0048856
GO:0060443
GO:0070301
GO:1902170
HGNC:11368
HPA001861
Hs.524518
ILMN_1763198
IPR000980
IPR001217
IPR008967
IPR011992
IPR012345
IPR013799
IPR013800
IPR013801
IPR015988
IPR028187
MIM:601512
NM_001178078
NM_001178079
NM_001178080
NM_001178081
NM_003153
NP_001171549
NP_001171550
NP_001171551
NP_001171552
NP_003144
PF00017
PF01017
PF02864
PF02865
PF14596
PH_hs_0036005
Q5FBW6
SM00252
SM00964
STAT6
STAT6-201
STAT6-202
STAT6-203
STAT6-204
STAT6-205
STAT6-220
TC12001620.hg
TC12002913.hg
U16031
U16031_at
uc001sna.5
uc009zpe.5
uc009zpf.5
uc010srb.4
uc010srd.4
uc058psk.1
UPI00000473FE
UPI0000153B81
XM_006719575
XM_011538703
XM_011538704
XM_011538705
XM_011538706
XM_011538707
XM_011538708
XM_011538709
XP_006719638
XP_011537005
XP_011537006
XP_011537007
XP_011537008
XP_011537009
XP_011537010
XP_011537011
Participant Of
input
p-S407,Y641-STAT6 is dimerized
hasComponent
p-S407,Y641-STAT6 dimer [cytosol]
output
p-S407-STAT6 is phosphorylated at Tyr641
Other forms of this molecule
p-Y641-STAT6 [cytosol]
p-Y641-STAT6 [nucleoplasm]
STAT6 [cytosol]
p-S407-STAT6 [cytosol]
p-S407,Y641-STAT6 [nucleoplasm]
Inferred To
phospho-p-S407,Y641-STAT6 [cytosol] (Bos taurus)
phospho-p-S407,Y641-STAT6 [cytosol] (Canis familiaris)
phospho-p-S407,Y641-STAT6 [cytosol] (Danio rerio)
phospho-p-S407,Y641-STAT6 [cytosol] (Drosophila melanogaster)
phospho-p-S407,Y641-STAT6 [cytosol] (Gallus gallus)
phospho-p-S407,Y641-STAT6 [cytosol] (Mus musculus)
phospho-p-S407,Y641-STAT6 [cytosol] (Rattus norvegicus)
phospho-p-S407,Y641-STAT6 [cytosol] (Sus scrofa)
phospho-p-S407,Y641-STAT6 [cytosol] (Taeniopygia guttata)
phospho-p-S407,Y641-STAT6 [cytosol] (Xenopus tropicalis)
Homologues of p-S407,Y641-STAT6 [cytosol] (Danio rerio)
Homologues of p-S407,Y641-STAT6 [cytosol] (Gallus gallus)
Homologues of p-S407,Y641-STAT6 [cytosol] (Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 407
Coordinate
407
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 641
Coordinate
641
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001171550.1
,
NP_001171549.1
,
XP_006719638.1
,
NP_003144.3
,
NP_001171551.1
Brenda
4.1.1.3
ZINC - Substances
STAT6_HUMAN
GeneCards
P42226
DOCK Blaster
4Y5W
,
4Y5U
,
5D39
,
1OJ5
ZINC target
P42226
PRO
P42226
Orphanet
21864
ZINC - Predictions - Purchasable
STAT6_HUMAN
PDB
4Y5U
,
5NWX
,
1OJ5
,
5NWM
,
5D39
,
4Y5W
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24394 IL4R
2
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
IL4R [plasma membrane]
(R-HSA-449670)
0.643
4
UniProt:Q86WV6 TMEM173
5
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
TMEM173 [endoplasmic reticulum membrane]
(R-HSA-1834940)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
0.631
12
UniProt:Q9UHD2 TBK1
6
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
p-S172-TBK1 [plasma membrane]
(R-HSA-936983)
p-S172-TBK1 [endosome membrane]
(R-HSA-450290)
TBK1 [cytosol]
(R-HSA-166267)
0.577
7
UniProt:P42226 STAT6
6
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
STAT6 [cytosol]
(R-HSA-629625)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
0.524
2
UniProt:Q7Z434 MAVS
2
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
0.462
3
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