Reactome | N-glycan M [endoplasmic reticulum membrane]

N-glycan M [endoplasmic reticulum membrane]

Stable Identifier

R-COV-9694684

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

endoplasmic reticulum membrane

Synonyms

P0DTC5

Locations in the PathwayBrowser

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General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

Literature References

PubMed ID	Title	Journal	Year
16442106	Characterization of severe acute respiratory syndrome coronavirus membrane protein Eickmann, M, Voss, D, Kern, A, Lanzavecchia, A, Becker, S, Traggiai, E, Stadler, K	FEBS Lett.	2006

External Reference Information

External Reference

UniProt:P0DTC5 M

Gene Names

Chain

chain:1-222

Reference Genes

KEGG Gene (Viruses):43740571 M

Participates

as an output of

M protein gets N-glycosylated (Homo sapiens)

as an input of

Glycosylated M localizes to the Golgi membrane (Homo sapiens)

Other forms of this molecule

M [plasma membrane]

N-glycan M [virion membrane]

M [virion membrane]

M [endocytic vesicle membrane]

N-glycan M [endocytic vesicle membrane]

M [endoplasmic reticulum-Golgi intermediate compartment membrane]

N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]

M [endoplasmic reticulum membrane]

nascent M [endoplasmic reticulum lumen]

Inferred From

N-glycan M [endoplasmic reticulum membrane] (Human SARS coronavirus)

Modified Residues

Name

N-glycosylated residue at 5

Coordinate

PsiMod Name

N-glycosylated residue

PsiMod Definition

A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond.

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

PDB

7VGS, 7VGR, 8CTK

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.733	11
UniProt:Q9UHD2 TBK1	4	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.681	10
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.674	6
UniProt:O75439 PMPCB	1	PMPCB [mitochondrial inner membrane] (R-HSA-1299434)	0.643	3
UniProt:Q96HW7 INTS4	1	INTS4 [nucleoplasm] (R-HSA-6807462)	0.643	3
UniProt:Q00765 REEP5			0.643	3
UniProt:Q96D53 COQ8B			0.643	3
UniProt:Q5JRX3 PITRM1	1	PITRM1 [mitochondrial matrix] (R-HSA-8986159)	0.643	3
UniProt:P05026 ATP1B1	1	ATP1B1 [plasma membrane] (R-HSA-375071)	0.643	3
UniProt:Q9NQC3 RTN4	1	RTN4 [plasma membrane] (R-HSA-194556)	0.643	3
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.621	3
UniProt:P0DTC4 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [virion membrane] (R-COV-9698416)	0.589	3
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.573	4
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.573	3
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.553	2
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.547	2
UniProt:Q96JB5 CK5P3			0.547	2
UniProt:P08236 GUSB	9	GUSB R611W [lysosomal lumen] (R-HSA-2318382) GUSB R216W [lysosomal lumen] (R-HSA-2318584) GUSB A354V [lysosomal lumen] (R-HSA-2318376) GUSB R356* [lysosomal lumen] (R-HSA-2318372) GUSB [lysosomal lumen] (R-HSA-1678846) GUSB [ficolin-1-rich granule lumen] (R-HSA-6800967) GUSB [extracellular region] (R-HSA-6806207) GUSB [azurophil granule lumen] (R-HSA-6799122) GUSB S52F [lysosomal lumen] (R-HSA-2318391)	0.547	2
UniProt:Q9UI26 IPO11			0.547	2
UniProt:Q96MT1 RN145			0.547	2
UniProt:O15063 GARRE1	1	KIAA0355 [cytosol] (R-HSA-9691200)	0.547	2
UniProt:Q96RQ1 ERGI2			0.547	2
UniProt:O00482 NR5A2	1	NR5A2 [nucleoplasm] (R-HSA-9011735)	0.547	2
UniProt:Q9C029 TRIM7			0.547	2
UniProt:Q9UBQ6 EXTL2	1	EXTL2 [endoplasmic reticulum membrane] (R-HSA-8953372)	0.547	2
UniProt:Q86UA1 PRP39			0.547	2
IntAct:EBI-26608251 NC			0.541	4
UniProt:P38435 GGCX	1	GGCX [endoplasmic reticulum membrane] (R-HSA-159860)	0.527	2
UniProt:P11310 ACADM	1	ACADM [mitochondrial matrix] (R-HSA-49491)	0.527	2
UniProt:Q9UBU6 FA8A1			0.527	2
UniProt:Q9Y6E2 5MP1			0.527	2
UniProt:Q15758 SLC1A5	1	SLC1A5 [plasma membrane] (R-HSA-352376)	0.527	2
UniProt:Q9BSJ2 TUBGCP2	1	TUBGCP2 [cytosol] (R-HSA-379275)	0.527	2
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.527	2
UniProt:Q96CW5 TUBGCP3	1	TUBGCP3 [cytosol] (R-HSA-379276)	0.527	2
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.527	2
UniProt:Q6PML9 ZNT9			0.527	2
UniProt:Q9UDR5 AASS	1	AASS [mitochondrial matrix] (R-HSA-70924)	0.527	2
UniProt:P13804 ETFA	1	ETFA(1-?) [mitochondrial matrix] (R-HSA-169262)	0.527	2
UniProt:Q9BQT8 SLC25A21	1	SLC25A21 [mitochondrial inner membrane] (R-HSA-372474)	0.527	2
UniProt:P38606 ATP6V1A	1	ATP6V1A [cytosol] (R-HSA-912602)	0.527	2
UniProt:Q10713 PMPCA	1	PMPCA [mitochondrial inner membrane] (R-HSA-1299450)	0.527	2
UniProt:Q96HR9 REEP6			0.527	2
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.527	2
UniProt:Q7L8L6 FASTKD5	1	FASTKD5 [mitochondrial matrix] (R-HSA-9837206)	0.527	2
UniProt:Q9Y6D5 ARFGEF2	1	ARFGEF2 [cytosol] (R-HSA-391301)	0.527	2
UniProt:Q9BW92 TARS2	1	TARS2(1-?) [mitochondrial matrix] (R-HSA-379590)	0.527	2
UniProt:Q93084 ATP2A3	2	ATP2A3 [platelet dense tubular network membrane] (R-HSA-427902) ATP2A3 [endoplasmic reticulum membrane] (R-HSA-391965)	0.527	2
UniProt:P27105 STOM	4	STOM [specific granule membrane] (R-HSA-6799569) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [tertiary granule membrane] (R-HSA-6800960)	0.527	2
UniProt:Q8NEW0 ZNT7			0.527	2
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.527	2
UniProt:Q96ER3 SAAL1			0.527	2
UniProt:Q9Y312 AAR2			0.527	2
UniProt:Q4KMQ2 ANO6	3	ANO6 [tertiary granule membrane] (R-HSA-6800903) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [specific granule membrane] (R-HSA-6799509)	0.527	2
UniProt:Q07021-PRO_0000018590 C1QBP			0.524	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.483	2
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.463	3
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.463	2

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