Reactome | K63polyUb-NLRP3 [cytosol]

K63polyUb-NLRP3 [cytosol]

Stable Identifier

R-HSA-6783288

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NACHT, LRR and PYD domains-containing protein 3, NALP3_HUMAN, Cryopyrin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96P20 NLRP3

Gene Names

NLRP3, C1orf7, CIAS1, NALP3, PYPAF1

Chain

chain:1-1036

Reference Genes

BioGPS Gene:114548 NLRP3

COSMIC (genes):NLRP3 NLRP3

CTD Gene:114548 NLRP3

dbSNP Gene:114548 NLRP3

ENSEMBL:ENSG00000162711 NLRP3

HGNC:16400 NLRP3

KEGG Gene (Homo sapiens):114548 NLRP3

Monarch:114548 NLRP3

NCBI Gene:114548 NLRP3

OMIM:606416 NLRP3

UCSC:Q96P20 NLRP3

Reference Transcript

Other Identifiers

0000540278

0001240484

114548

11738183_a_at

11738523_a_at

16679697

207075_at

216015_s_at

216016_at

2390051

2390052

2390053

2390054

2390055

2390056

2390057

2390058

2390059

2390064

2390065

2390072

2390073

2390074

2390076

2390078

2390079

2390080

2390081

2390082

2390083

2390084

2390085

2390086

33598_r_at

7911178

A_14_P105324

A_33_P3281695

GE81454

GO:0000139

GO:0000166

GO:0002376

GO:0002523

GO:0002674

GO:0002830

GO:0003674

GO:0003677

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0006464

GO:0006915

GO:0006950

GO:0006952

GO:0006954

GO:0007155

GO:0007165

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0009595

GO:0014070

GO:0016020

GO:0016579

GO:0030154

GO:0032088

GO:0032691

GO:0032731

GO:0032753

GO:0032991

GO:0034641

GO:0035590

GO:0040011

GO:0042802

GO:0042834

GO:0043167

GO:0043226

GO:0043280

GO:0043565

GO:0045087

GO:0045471

GO:0045630

GO:0045944

GO:0048856

GO:0048870

GO:0050728

GO:0051092

GO:0061702

GO:0071222

GO:0072559

GO:1901223

GO:2000553

HMNXSV003019453

Hs.159483.1.S1_3p_a_at

Hs.159483.1.S1_3p_at

ILMN_1696933

ILMN_1712026

ILMN_1713379

ILMN_2310896

PH_hs_0029274

TC01002008.hg

g4757727_3p_at

Participates

as a component of

BRISC complex:K63polyUb-NLRP3 [cytosol] (Homo sapiens)

Other forms of this molecule

NLRP3 [cytosol]

Inferred To

Nlrp3 [cytosol] (Mus musculus)

Nlrp3 [cytosol] (Rattus norvegicus)

NLRP3 [cytosol] (Canis familiaris)

NLRP3 [cytosol] (Sus scrofa)

Ghost homologue of K63polyUb-NLRP3 [cytosol] (Gallus gallus)

Ghost homologue of K63polyUb-NLRP3 [cytosol] (Xenopus tropicalis)

LOC103910107 [cytosol] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001120934.1, XP_016855671.1, XP_016855670.1, NP_001073289.1, NP_899632.1, NP_001230062.1, XP_011542350.1, NP_001120933.1, XP_016855673.1, XP_016855672.1, NP_004886.3

Guide to Pharmacology - Targets

1770

OpenTargets

ENSG00000162711

GeneCards

Q96P20

HPA

ENSG00000162711-NLRP3

Ensembl

ENSP00000375704, ENSP00000375703, ENST00000474792, ENST00000348069, ENSP00000337383, ENST00000391828, ENST00000391827, ENSP00000493674, ENST00000366497, ENST00000643234, ENSP00000294752, ENST00000366496, ENSP00000355452, ENSP00000355453, ENSG00000162711, ENST00000336119, ENSP00000493937

PRO

Q96P20

Pharos - Targets

Q96P20

Orphanet

16553

PDB

6NPY, 3QF2, 2NAQ, 7ALV

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957)	0.917	24
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.675	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.628	18
UniProt:P19525 EIF2AK2	1	EIF2AK2 [cytosol] (R-HSA-168699)	0.602	6
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.573	2
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	4
UniProt:P36957 DLST	2	DLST [mitochondrial matrix] (R-HSA-6792574) Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:Q9ES74 NEK7			0.524	2
UniProt:Q80H93 8b	1	8b [cytosol] (R-COV-9678168)	0.463	7

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