Reactome | K63polyUb-NLRP3 [cytosol]

K63polyUb-NLRP3 [cytosol]

Stable Identifier

R-HSA-6783288

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NACHT, LRR and PYD domains-containing protein 3, NALP3_HUMAN, Cryopyrin

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96P20 NLRP3

Gene Names

NLRP3, C1orf7, CIAS1, NALP3, PYPAF1

Chain

chain:1-1036

Reference Genes

BioGPS Gene:114548 NLRP3

COSMIC (genes):NLRP3 NLRP3

CTD Gene:114548 NLRP3

dbSNP Gene:114548 NLRP3

ENSEMBL:ENSG00000162711 NLRP3

HGNC:16400 NLRP3

KEGG Gene (Homo sapiens):114548 NLRP3

Monarch:114548 NLRP3

NCBI Gene:114548 NLRP3

OMIM:606416 NLRP3

UCSC:Q96P20 NLRP3

Reference Transcript

Participates

as a component of

BRISC complex:K63polyUb-NLRP3 [cytosol] (Homo sapiens)

Other forms of this molecule

NLRP3 [cytosol]

Inferred To

LOC108644478 [cytosol] (Xenopus tropicalis)

K63polyUb-NLRP3 [cytosol] (Bos taurus)

K63polyUb-NLRP3 [cytosol] (Gallus gallus)

K63polyUb-NLRP3 [cytosol] (Mus musculus)

K63polyUb-NLRP3 [cytosol] (Rattus norvegicus)

NLRP3 [cytosol] (Canis familiaris)

NLRP3 [cytosol] (Sus scrofa)

LOC100491706 [cytosol] (Xenopus tropicalis)

Homologues of K63polyUb-NLRP3 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_016855670.1, NP_001230062.1, NP_899632.1, XP_011542350.1, NP_001073289.1, NP_001120933.1, XP_016855673.1, XP_016855671.1, NP_001120934.1, XP_016855672.1, NP_004886.3

Guide to Pharmacology - Targets

1770

OpenTargets

ENSG00000162711

GeneCards

Q96P20

PRO

Q96P20

Pharos - Targets

Q96P20

Orphanet

16553

PDB

8ERT, 8EJ4, 7ALV, 2NAQ, 6NPY, 8SWF, 3QF2, 8WSM, 8SWK, 7ZGU, 7PZC, 7VTP, 8RI2, 8ETR, 7PZD, 8SXN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957)	0.948	26
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.675	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.628	18
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.602	6
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.573	2
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	4
UniProt:Q9ES74 NEK7			0.524	2
UniProt:Q80H93 8b	1	8b [cytosol] (R-COV-9678168)	0.463	7

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