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UBE4A [cytosol]
Stable Identifier
R-HSA-976022
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin conjugation factor E4 A, UBE4A_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14139 UBE4A
Gene Names
UBE4A, KIAA0126
Chain
chain:1-1066
Reference Genes
BioGPS Gene:9354 UBE4A
COSMIC (genes):UBE4A UBE4A
CTD Gene:9354 UBE4A
dbSNP Gene:9354 UBE4A
ENSEMBL:ENSG00000110344 UBE4A
HGNC:12499 UBE4A
KEGG:hsa:9354 UBE4A
Monarch:9354 UBE4A
NCBI Gene:9354 UBE4A
OMIM:603753 UBE4A
UCSC:Q14139 UBE4A
Reference Transcript
RefSeq:NM_001204077.1 UBE4A
RefSeq:NM_004788.3 UBE4A
Other Identifiers
11716840_at
11716841_at
11750790_a_at
16731822
202038_PM_at
202038_at
3351316
3351317
3351321
3351322
3351327
3351328
3351329
3351331
3351333
3351334
3351335
3351336
3351337
3351338
3351339
3351340
3351341
3351342
3351343
3351345
3351346
3351349
3351353
3351354
3351357
3351358
3351360
3351361
3351362
36579_at
71836_at
7944195
80158_at
9354
A_14_P119728
A_23_P203137
D50916_at
GE56285
GE57253
GE86529
GO:0000151
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005737
GO:0006511
GO:0016567
GO:0016740
GO:0030163
GO:0034450
GO:0036503
GO:0043226
GO:0140096
HMNXSV003022596
ILMN_1739259
PH_hs_0004304
TC11001062.hg
g4759287_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
UBE4A [cytosol]
(Bos taurus)
UBE4A [cytosol]
(Canis familiaris)
UBE4A [cytosol]
(Gallus gallus)
UBE4A [cytosol]
(Plasmodium falciparum)
UBE4A [cytosol]
(Sus scrofa)
Ube4a [cytosol]
(Mus musculus)
Ube4a [cytosol]
(Rattus norvegicus)
ufd2 [cytosol]
(Schizosaccharomyces pombe)
UFD2 [cytosol]
(Saccharomyces cerevisiae)
ube4a [cytosol]
(Xenopus tropicalis)
Ube4A [cytosol]
(Drosophila melanogaster)
nosA [cytosol]
(Dictyostelium discoideum)
Cross References
ENSEMBL
ENST00000252108
,
ENSP00000252108
,
ENSG00000110344
,
ENST00000431736
,
ENSP00000387362
OpenTargets
ENSG00000110344
IntEnz
2.3.2.27
GeneCards
UBE4A
HPA
ENSG00000110344-UBE4A
PRO
Q14139
Pharos - Targets
Q14139
GlyGen
Q14139
HMDB Protein
HMDBP11575
PDB
1WGM
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.499
2
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