Reactome | G76-NEDD8-K724-CUL5 [cytosol]

G76-NEDD8-K724-CUL5 [cytosol]

Stable Identifier

R-HSA-8952014

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cullin-5

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q93034 CUL5

Gene Names

CUL5, VACM1

Chain

chain:1-780

Reference Genes

BioGPS Gene:8065 CUL5

COSMIC (genes):CUL5 CUL5

CTD Gene:8065 CUL5

dbSNP Gene:8065 CUL5

ENSEMBL:ENSG00000166266 CUL5

HGNC:2556 CUL5

KEGG:hsa:8065 CUL5

Monarch:8065 CUL5

NCBI Gene:8065 CUL5

OMIM:601741 CUL5

UCSC:Q93034 CUL5

Reference Transcript

RefSeq:NM_003478.4 CUL5

Other Identifiers

11722477_at

11722478_a_at

11722479_a_at

16730792

203531_PM_at

203531_at

203532_PM_x_at

203532_x_at

203533_PM_s_at

203533_s_at

3347550

3347551

3347552

3347561

3347564

3347568

3347569

3347571

3347572

3347573

3347574

3347578

3347579

3347580

3347581

3347582

3347584

3347585

3347587

3347588

3347589

3347592

3347594

3347597

3347598

3347599

3347600

3347601

3347602

3347603

3347604

3347605

3347606

3347607

3347612

41110_at

58347_at

7943580

8065

A_14_P137105

A_23_P203009

A_33_P3301286

GE81285

GO:0000082

GO:0003824

GO:0004842

GO:0005215

GO:0005262

GO:0005515

GO:0005634

GO:0005829

GO:0006511

GO:0016567

GO:0016740

GO:0019005

GO:0030163

GO:0030674

GO:0031146

GO:0031461

GO:0031466

GO:0031625

GO:0038023

GO:0038026

GO:0038128

GO:0043161

GO:0043226

GO:0055085

GO:0060089

GO:0060090

GO:0070588

GO:0070979

GO:0090734

GO:0097193

GO:0140096

GO:0160072

GO:2001222

HMNXSV003038673

Hs.101299.0.A3_3p_at

ILMN_2176955

PH_hs_0040189

TC11000977.hg

X81882_at

g2394273_3p_a_at

g4503166_3p_a_at

g4503166_3p_x_at

Participates

as a component of

NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)

Other forms of this molecule

CUL5 [cytosol]

Inferred To

Cul5 [cytosol] (Drosophila melanogaster)

Cul5 [cytosol] (Mus musculus)

Cul5 [cytosol] (Rattus norvegicus)

Homologues of G76-NEDD8-K724-CUL5 [cytosol] (Dictyostelium discoideum)

cul-5 [cytosol] (Caenorhabditis elegans)

cul5a [cytosol] (Danio rerio)

culA [cytosol] (Dictyostelium discoideum)

cul5 [cytosol] (Xenopus tropicalis)

culB [cytosol] (Dictyostelium discoideum)

CUL5 [cytosol] (Bos taurus)

CUL5 [cytosol] (Canis familiaris)

CUL5 [cytosol] (Sus scrofa)

G76-NEDD8-K724-CUL5 [cytosol] (Gallus gallus)

culE [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

neddylated lysine (monoNEDD8 [cytosol]) at 724

Coordinate

724

Modification

monoNEDD8 [cytosol]

PsiMod Name

neddylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.

Cross References

RefSeq

NP_003469.2

OpenTargets

ENSG00000166266

ENSEMBL

ENSP00000435376, ENST00000393094, ENSP00000376808, ENST00000531427

HPA

ENSG00000166266-CUL5

PRO

Q93034

Pharos - Targets

Q93034

GlyGen

Q93034

HMDB Protein

HMDBP01827

PDB

8FVI, 8FVJ, 6V9I, 4N9F, 4JGH, 8EI2, 3DPL, 3DQV, 7ONI

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14508 SOCS2	1	SOCS2 [cytosol] (R-HSA-1169204)	0.88	11
UniProt:Q9UBF6 RNF7	1	RNF7 (RBX2) [cytosol] (R-HSA-8863132)	0.871	11
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.802	7
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.784	6
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.784	11
UniProt:Q9Y576 ASB1	1	ASB1 [cytosol] (R-HSA-975428)	0.744	8
UniProt:Q9H672 ASB7	1	ASB7 [cytosol] (R-HSA-975425)	0.744	5
UniProt:P12504 VIF			0.742	11
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.677	13
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:O95273 CCDB1			0.666	4
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.643	7
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.643	8
UniProt:Q6PJ21 SPSB3	1	SPSB3 [cytosol] (R-HSA-400242)	0.643	4
UniProt:Q9NV79 PCMD2			0.643	6
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.643	5
UniProt:Q96A44 SPSB4	1	SPSB4 [cytosol] (R-HSA-976023)	0.643	3
UniProt:O14512 SOCS7			0.643	4
UniProt:Q12829 RAB40B	2	GGC-RAB40B [cytosol] (R-HSA-8874024) RAB40B [cytosol] (R-HSA-8873718)	0.643	5
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.643	6
UniProt:Q96MG8 PCMD1			0.643	5
UniProt:Q8WXK3 ASB13	1	ASB13 [cytosol] (R-HSA-975427)	0.643	7
UniProt:Q9UK73 FEM1B	1	FEM1B [cytosol] (R-HSA-201572)	0.643	3
UniProt:Q9NRJ4 TULP4	1	TULP4 [cytosol] (R-HSA-8863142)	0.643	4
UniProt:Q9Y2U9 KLDC2			0.643	4
UniProt:Q9Y6I7 WSB1	1	WSB1 [cytosol] (R-HSA-976016)	0.643	6
UniProt:Q9NYS7 WSB2	1	WSB2 [cytosol] (R-HSA-8863349)	0.643	5
UniProt:Q15369-1 ELOC			0.612	4
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.612	5
UniProt:Q15370-1 ELOB			0.612	4
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.611	3
UniProt:Q96Q27-2 ASB2			0.564	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q5T7N3 KANK4			0.556	3
UniProt:Q9NPC3 CIP1			0.556	3
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.556	3
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [cytosol] (R-HSA-8951781) DCUN1D1 [nucleoplasm] (R-HSA-8952487)	0.527	6
UniProt:Q9H765 ASB8	1	ASB8 [cytosol] (R-HSA-975422)	0.527	3
UniProt:Q5TA31 RN187			0.527	2
UniProt:Q9BSK4 FEM1A	1	FEM1A [cytosol] (R-HSA-8863141)	0.527	2
UniProt:Q9Y575 ASB3	1	ASB3 [cytosol] (R-HSA-975411)	0.527	7
UniProt:Q96CX6 LRC58			0.527	2
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.527	2
UniProt:O75159 SOCS5	1	SOCS5 [cytosol] (R-HSA-6788342)	0.527	3
UniProt:P50579 METAP2	1	METAP2 [cytosol] (R-HSA-2534094)	0.527	2
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.527	3
UniProt:Q8WXH6 RAB40A	2	GGC-RAB40A [cytosol] (R-HSA-8874021) RAB40A [cytosol] (R-HSA-8873694)	0.527	3
UniProt:P0C0E4 RB40L			0.527	2
UniProt:Q02880 TOP2B	2	monoSUMO1-K-TOP2B [nucleoplasm] (R-HSA-4641297) TOP2B [nucleoplasm] (R-HSA-4641359)	0.527	2
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.527	3
UniProt:Q15345 LRRC41	1	LRRC41 [cytosol] (R-HSA-976015)	0.527	5
UniProt:Q9Y314 NOSIP	2	NOSIP [Golgi membrane] (R-HSA-535001) NOSIP [cytosol] (R-HSA-203636)	0.527	2
UniProt:Q96JP0 FEM1C	1	FEM1C [cytosol] (R-HSA-8863167)	0.527	2
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089)	0.527	9
UniProt:Q9H9Q2 COPS7B	2	COPS7B [nucleoplasm] (R-HSA-5697023) COPS7B [cytosol] (R-HSA-416966)	0.527	3
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.524	4

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