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SPSB3 [cytosol]
Stable Identifier
R-HSA-400242
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SPRY domain-containing SOCS box protein 3, SPSB3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6PJ21 SPSB3
Gene Names
SPSB3, C16orf31, SSB3
Chain
chain:1-355
Reference Genes
BioGPS Gene:90864 SPSB3
COSMIC (genes):SPSB3 SPSB3
CTD Gene:90864 SPSB3
dbSNP Gene:90864 SPSB3
ENSEMBL:ENSG00000162032 SPSB3
HGNC:30629 SPSB3
KEGG:hsa:90864 SPSB3
Monarch:90864 SPSB3
NCBI Gene:90864 SPSB3
OMIM:611659 SPSB3
UCSC:Q6PJ21 SPSB3
Reference Transcript
RefSeq:NM_001324081.1 SPSB3
RefSeq:NM_080861.3 SPSB3
Other Identifiers
11716731_a_at
11750057_a_at
11755340_a_at
16822815
221769_PM_at
221769_at
3676135
3676136
3676137
3676138
3676139
3676140
3676141
3676142
3676143
3676144
3676145
3676146
3676147
3676150
3676151
3676152
3676153
3676154
3676155
3676162
46256_PM_at
46256_at
7998590
90864
A_23_P330532
A_23_P330537
A_23_P3496
A_33_P3235716
GE87621
GO:0005515
GO:0005634
GO:0005829
GO:0010719
GO:0016567
GO:0019005
GO:0030163
GO:0031466
GO:0043161
GO:0043226
GO:0060090
GO:0070936
GO:0160049
GO:1990756
HMNXSV003032479
Hs.7247.0.S1_3p_s_at
ILMN_1682864
PH_hs_0027064
TC16000760.hg
Participates
as a member of
CUL5-box protein [cytosol] (Homo sapiens)
Inferred To
spsb3 [cytosol]
(Xenopus tropicalis)
Dmel\CG10516 [cytosol]
(Drosophila melanogaster)
Spsb3 [cytosol]
(Mus musculus)
Spsb3 [cytosol]
(Rattus norvegicus)
spsb3a [cytosol]
(Danio rerio)
SPSB3 [cytosol]
(Bos taurus)
SPSB3 [cytosol]
(Canis familiaris)
SPSB3 [cytosol]
(Dictyostelium discoideum)
SPSB3 [cytosol]
(Gallus gallus)
SPSB3 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000457206
,
ENST00000301717
,
ENST00000566339
,
ENSP00000301717
OpenTargets
ENSG00000162032
HPA
ENSG00000162032-SPSB3
PRO
Q6PJ21
Pharos - Targets
Q6PJ21
PDB
8OKX
,
8OL1
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.643
4
UniProt:Q8NB12 SMYD1
1
SMYD1 [nucleoplasm]
(R-HSA-5688412)
0.527
2
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