Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DCUN1D1 [cytosol]
Stable Identifier
R-HSA-8951781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DCN1-like protein 1, DCNL1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
DCUN1Ds [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
DCUN1D1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GG9 DCUN1D1
Gene Names
DCUN1D1, DCN1, DCUN1L1, RP42, SCCRO
Chain
chain:1-259
Reference Genes
BioGPS Gene:54165 DCUN1D1
COSMIC (genes):DCUN1D1 DCUN1D1
CTD Gene:54165 DCUN1D1
dbSNP Gene:54165 DCUN1D1
ENSEMBL:ENSG00000043093 DCUN1D1
ENSEMBL_homo_sapiens_GENE:ENSG00000043093.15 DCUN1D1
HGNC:18184 DCUN1D1
KEGG Gene (Homo sapiens):54165 DCUN1D1
Monarch:54165 DCUN1D1
NCBI Gene:54165 DCUN1D1
OMIM:605905 DCUN1D1
UCSC:Q96GG9 DCUN1D1
Reference Transcript
RefSeq:NM_020640.3 DCUN1D1
RefSeq:NM_001308101.1 DCUN1D1
Other Identifiers
11726326_a_at
11726327_at
11751625_a_at
11764171_s_at
16961974
218583_PM_s_at
218583_s_at
222678_PM_s_at
222678_s_at
222679_PM_s_at
222679_s_at
237408_PM_at
237408_at
238879_PM_at
238879_at
240781_3p_x_at
240781_PM_x_at
240781_x_at
243396_PM_at
243396_at
2707770
2707771
2707772
2707773
2707774
2707775
2707776
2707777
2707778
2707779
2707780
2707781
2707790
2707791
2707792
2707793
2707808
2918903
3293523
44340_at
47094_r_at
47812_at
54165
56808_at
58439_at
62294_at
62944_at
75613_at
8092321
A_19_P00317933
A_19_P00325903
A_19_P00810971
A_23_P144145
A_24_P166012
A_33_P3290328
GE61678
GE894652
GE897271
GO:0000151
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0031396
GO:0031624
GO:0032182
GO:0036211
GO:0043226
GO:0045116
GO:0097602
GO:2000434
GO:2000436
HMNXSV003012722
HMNXSV003028881
Hs.104613.0.A1_3p_a_at
Hs.104613.0.A2_3p_a_at
Hs.260282.0.A1_3p_at
Hs.260282.1.S1_3p_at
Hs.288442.0.A1_3p_at
Hs.6656.0.A1_3p_at
ILMN_1810719
ILMN_2043865
PH_hs_0029072
PH_hs_0040582
TC03002052.hg
g10190677_3p_a_at
Participates
as a candidate of
DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
as a member of
DCUN1Ds [cytosol] (Homo sapiens)
Other forms of this molecule
DCUN1D1 [nucleoplasm]
Inferred To
Dcun1d1 [cytosol]
(Mus musculus)
Dcun1d1 [cytosol]
(Rattus norvegicus)
SCCRO [cytosol]
(Drosophila melanogaster)
DCN1 [cytosol]
(Saccharomyces cerevisiae)
dcun1d1 [cytosol]
(Danio rerio)
dcun1d1 [cytosol]
(Xenopus tropicalis)
dcn1 [cytosol]
(Schizosaccharomyces pombe)
DCUN1D1 [cytosol]
(Bos taurus)
DCUN1D1 [cytosol]
(Canis familiaris)
DCUN1D1 [cytosol]
(Dictyostelium discoideum)
DCUN1D1 [cytosol]
(Gallus gallus)
dcn-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_065691.2
,
NP_001295030.1
OpenTargets
ENSG00000043093
GeneCards
Q96GG9
HPA
ENSG00000043093-DCUN1D1
Ensembl
ENST00000292782
,
ENSG00000043093
,
ENSP00000292782
PRO
Q96GG9
Pharos - Targets
Q96GG9
PDB
5V88
,
6XON
,
4P5O
,
6P5W
,
8OR3
,
6P5V
,
8OR2
,
6XOM
,
6XOQ
,
7KWA
,
5V86
,
5V83
,
6XOL
,
3TDZ
,
6XOP
,
5UFI
,
6BG5
,
6B5Q
,
6BG3
,
6XOO
,
3TDU
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.744
5
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.669
7
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.527
6
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.488
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text