Reactome | FEM1C [cytosol]

FEM1C [cytosol]

Stable Identifier

R-HSA-8863167

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein fem-1 homolog C, FEM1C_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96JP0 FEM1C

Gene Names

FEM1C, KIAA1785

Chain

chain:1-617

Reference Genes

BioGPS Gene:56929 FEM1C

COSMIC (genes):FEM1C FEM1C

CTD Gene:56929 FEM1C

dbSNP Gene:56929 FEM1C

ENSEMBL:ENSG00000145780 FEM1C

ENSEMBL_homo_sapiens_GENE:ENSG00000145780.8 FEM1C

HGNC:16933 FEM1C

KEGG Gene (Homo sapiens):56929 FEM1C

Monarch:56929 FEM1C

NCBI Gene:56929 FEM1C

OMIM:608767 FEM1C

UCSC:Q96JP0 FEM1C

Reference Transcript

Other Identifiers

11723272_at

11723273_at

16999011

213341_PM_at

213341_at

2871802

2871803

2871804

2871805

2871806

2871809

2871810

2871811

2871812

2871813

2871814

39976_at

56929

8113616

A_23_P41697

A_23_P417237

A_33_P3383871

GE56242

GO:0000151

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006511

GO:0016567

GO:0030163

GO:0031462

GO:0036211

GO:0043161

GO:0043226

GO:0060090

GO:0140627

GO:1990756

HMNXSV003007982

Hs.47367.0.A1_3p_at

ILMN_1703330

PH_hs_0028891

TC05001689.hg

Participates

as a member of

CUL2-box protein [cytosol] (Homo sapiens)

Inferred To

fem-1 [cytosol] (Caenorhabditis elegans)

m-cup [cytosol] (Drosophila melanogaster)

Homologues of FEM1C [cytosol] (Drosophila melanogaster)

fem1c [cytosol] (Danio rerio)

fem1c [cytosol] (Xenopus tropicalis)

FEM1C [cytosol] (Bos taurus)

FEM1C [cytosol] (Canis familiaris)

FEM1C [cytosol] (Drosophila melanogaster)

FEM1C [cytosol] (Gallus gallus)

FEM1C [cytosol] (Sus scrofa)

Fem1c [cytosol] (Mus musculus)

Fem1c [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_064562.1, XP_005272092.1

OpenTargets

ENSG00000145780

GeneCards

Q96JP0

HPA

ENSG00000145780-FEM1C

Ensembl

ENST00000274457, ENSG00000145780, ENSP00000274457

PRO

Q96JP0

Pharos - Targets

Q96JP0

PDB

6LBG, 8PQL, 8Q7R, 6LEN, 6LF0, 6LEY, 6LE6, 6LDP, 7JYA, 6XKC, 6LBN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	2