Reactome | FEM1B [cytosol]

FEM1B [cytosol]

Stable Identifier

R-HSA-201572

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FEM1b

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UK73 FEM1B

Gene Names

FEM1B, F1AA, KIAA0396

Chain

chain:1-627

Reference Genes

BioGPS Gene:10116 FEM1B

COSMIC (genes):FEM1B FEM1B

CTD Gene:10116 FEM1B

dbSNP Gene:10116 FEM1B

ENSEMBL:ENSG00000169018 FEM1B

ENSEMBL:ENSG00000169018.6 FEM1B

HGNC:3649 FEM1B

KEGG Gene (Homo sapiens):10116 FEM1B

Monarch:10116 FEM1B

NCBI Gene:10116 FEM1B

OMIM:613539 FEM1B

UCSC:Q9UK73 FEM1B

Reference Transcript

RefSeq:NM_015322.4 FEM1B

Other Identifiers

10116

11734988_s_at

16802408

212367_PM_at

212367_at

212373_PM_at

212373_at

212374_PM_at

212374_at

35346_at

3599436

3599437

3599438

3599439

3599440

3599441

3599445

3599446

3599447

3599448

3599449

3599454

3599456

3599458

3599459

7984470

A_14_P134430

A_23_P151970

GE53157

GE81996

GO:0002070

GO:0005123

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006915

GO:0012501

GO:0016567

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0031462

GO:0036211

GO:0043161

GO:0043226

GO:0048856

GO:0051438

GO:0060090

GO:0060442

GO:0060743

GO:0140627

GO:1902041

GO:1990756

GO:2000001

HMNXSV003040323

Hs.6048.0.S1_3p_at

Hs.6048.0.S2_3p_at

Hs.6048.0.S3_3p_at

ILMN_1744239

ILMN_1836860

PH_hs_0035836

TC15000628.hg

Participates

as a member of

CUL2-box protein [cytosol] (Homo sapiens)

Inferred To

fem1b [cytosol] (Xenopus tropicalis)

FEM1B [cytosol] (Bos taurus)

FEM1B [cytosol] (Canis familiaris)

FEM1B [cytosol] (Danio rerio)

FEM1B [cytosol] (Gallus gallus)

FEM1B [cytosol] (Sus scrofa)

Fem1b [cytosol] (Mus musculus)

Fem1b [cytosol] (Rattus norvegicus)

Fem-1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_056137.1

OpenTargets

ENSG00000169018

HPA

ENSG00000169018-FEM1B

GeneCards

Q9UK73

Ensembl

ENSP00000307298, ENSG00000169018, ENST00000306917

PRO

Q9UK73

Pharos - Targets

Q9UK73

PDB

6LBF, 7CNG, 7EL6

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49593 PPM1F	1	PPM1F [cytosol] (R-HSA-9619454)	0.544	2
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	2

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