Reactome | SPSB4 [cytosol]

SPSB4 [cytosol]

Stable Identifier

R-HSA-976023

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SPRY domain-containing SOCS box protein 4, SPSB4_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96A44 SPSB4

Gene Names

SPSB4, SSB4

Chain

chain:1-273

Reference Genes

BioGPS Gene:92369 SPSB4

COSMIC (genes):SPSB4 SPSB4

CTD Gene:92369 SPSB4

dbSNP Gene:92369 SPSB4

ENSEMBL:ENSG00000175093 SPSB4

ENSEMBL_homo_sapiens_GENE:ENSG00000175093.5 SPSB4

HGNC:30630 SPSB4

KEGG Gene (Homo sapiens):92369 SPSB4

Monarch:92369 SPSB4

NCBI Gene:92369 SPSB4

OMIM:611660 SPSB4

UCSC:Q96A44 SPSB4

Reference Transcript

RefSeq:NM_080862.2 SPSB4

Other Identifiers

11723625_a_at

16946331

229929_PM_at

229929_at

2645319

2645320

2645321

2645322

2645323

2645324

2645325

2645334

2645335

2645336

2645358

2645359

2645360

54413_at

8083071

92369

A_14_P135559

A_23_P258381

GE574451

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0016567

GO:0019005

GO:0023052

GO:0030163

GO:0035556

GO:0036211

GO:0042752

GO:0043161

GO:0048511

GO:0060090

GO:1902916

GO:1990756

HMNXSV003041900

Hs.58219.0.A1_3p_at

ILMN_1736682

PH_hs_0003742

Participates

as a member of

CUL5-box protein [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

SPSB1 [cytosol] (Dictyostelium discoideum)

spsb-1 [cytosol] (Caenorhabditis elegans)

spsb4 [cytosol] (Xenopus tropicalis)

Homologues of SPSB4 [cytosol] (Caenorhabditis elegans)

Spsb4 [cytosol] (Mus musculus)

Spsb4 [cytosol] (Rattus norvegicus)

spsb-2 [cytosol] (Caenorhabditis elegans)

spsb4a [cytosol] (Danio rerio)

SPSB4 [cytosol] (Bos taurus)

SPSB4 [cytosol] (Canis familiaris)

SPSB4 [cytosol] (Gallus gallus)

SPSB4 [cytosol] (Sus scrofa)

gus [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_543138.1

OpenTargets

ENSG00000175093

HPA

ENSG00000175093-SPSB4

GeneCards

Q96A44

Ensembl

ENSP00000311609, ENSG00000175093, ENST00000310546

PRO

Q96A44

Pharos - Targets

Q96A44

PDB

2V24, 6DN8, 6DN7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.669	3
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.643	3
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.527	2