Reactome | SOCS5 [cytosol]

SOCS5 [cytosol]

Stable Identifier

R-HSA-6788342

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of cytokine signaling 5, SOCS5_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - SOCS5,(SOCS1) bind IL4RA (Homo sapiens)
        
        IL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1) [plasma membrane] (Homo sapiens)
        
        SOCS5,(SOCS1) [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
        
        SOCS5,(SOCS1) [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75159 SOCS5

Gene Names

SOCS5, CIS6, CISH5, CISH6, KIAA0671

Chain

chain:1-536

Reference Genes

BioGPS Gene:9655 SOCS5

COSMIC (genes):SOCS5 SOCS5

CTD Gene:9655 SOCS5

dbSNP Gene:9655 SOCS5

ENSEMBL:ENSG00000171150 SOCS5

ENSEMBL_homo_sapiens_GENE:ENSG00000171150.9 SOCS5

HGNC:16852 SOCS5

KEGG Gene (Homo sapiens):9655 SOCS5

Monarch:9655 SOCS5

NCBI Gene:9655 SOCS5

OMIM:607094 SOCS5

UCSC:O75159 SOCS5

Reference Transcript

Other Identifiers

11729319_a_at

11729320_a_at

11740172_a_at

11740173_a_at

16879791

208127_PM_s_at

208127_s_at

209647_PM_s_at

209647_s_at

209648_PM_x_at

209648_x_at

2480620

2480621

2480631

2480632

2480633

2480634

2480635

2480636

2671580

2671585

2671586

2671589

2877228

2922084

32669_at

8041820

9655

A_14_P105713

A_23_P5813

A_24_P328492

GE53378

GO:0002376

GO:0005154

GO:0005515

GO:0005829

GO:0005942

GO:0006629

GO:0006954

GO:0007155

GO:0007173

GO:0007175

GO:0007259

GO:0009968

GO:0016567

GO:0019221

GO:0023052

GO:0030154

GO:0030163

GO:0030971

GO:0032436

GO:0032715

GO:0035556

GO:0036211

GO:0045627

GO:0045629

GO:0046854

GO:0046935

GO:0048856

GO:0050728

GO:0071404

GO:0071638

GO:0097699

GO:0098772

HMNXSV003037085

Hs.169836.1.S1_3p_a_at

ILMN_1715584

ILMN_1785286

ILMN_2262749

ILMN_2350970

PH_hs_0010123

TC02000286.hg

g7662239_3p_a_at

Participates

as a member of

Inferred To

socs5a [cytosol] (Danio rerio)

Socs5 [cytosol] (Mus musculus)

Socs5 [cytosol] (Rattus norvegicus)

socs5 [cytosol] (Xenopus tropicalis)

Socs36E [cytosol] (Drosophila melanogaster)

SOCS5 [cytosol] (Bos taurus)

SOCS5 [cytosol] (Canis familiaris)

SOCS5 [cytosol] (Gallus gallus)

SOCS5 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_659198.1, NP_054730.1

OpenTargets

ENSG00000171150

HPA

ENSG00000171150-SOCS5

GeneCards

O75159

Ensembl

ENSP00000305133, ENST00000394861, ENSG00000171150, ENSP00000378330, ENST00000306503

PRO

O75159

Pharos - Targets

O75159

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	3

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