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LRRC41 [cytosol]
Stable Identifier
R-HSA-976015
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Leucine-rich repeat-containing protein 41, LRC41_HUMAN, MUF1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
RHOBTB3 ATPase cycle (Homo sapiens)
RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Homo sapiens)
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
LRRC41 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15345 LRRC41
Gene Names
LRRC41, MUF1, PP7759
Chain
chain:1-812
Reference Genes
BioGPS Gene:10489 LRRC41
COSMIC (genes):LRRC41 LRRC41
CTD Gene:10489 LRRC41
dbSNP Gene:10489 LRRC41
ENSEMBL:ENSG00000132128 LRRC41
ENSEMBL_homo_sapiens_GENE:ENSG00000132128.18 LRRC41
HGNC:16917 LRRC41
KEGG Gene (Homo sapiens):10489 LRRC41
Monarch:10489 LRRC41
NCBI Gene:10489 LRRC41
OMIM:618753 LRRC41
UCSC:Q15345 LRRC41
Reference Transcript
RefSeq:NM_006369.4 LRRC41
Other Identifiers
10489
11747650_a_at
11754553_a_at
1555831_PM_s_at
1555831_s_at
16686611
201932_PM_at
201932_at
2410577
2410578
2410579
2410580
2410581
2410582
2410584
2410586
2410587
2410588
2410589
2410593
2410594
2410595
2410596
2410597
2410601
2410602
2410606
2410607
2410608
2410609
2410610
40807_at
42148_at
75933_at
7915827
A_33_P3289222
GE60104
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0016020
GO:0016567
GO:0036211
GO:0042802
GO:0043226
HMNXSV003004657
Hs2Affx.1.474.A1_3p_s_at
ILMN_1712755
PH_hs_0022592
TC01002618.hg
X86018_at
g5453747_3p_at
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
as a component of
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of LRRC41 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of LRRC41 [cytosol]
(Drosophila melanogaster)
Lrrc41 [cytosol]
(Mus musculus)
Lrrc41 [cytosol]
(Rattus norvegicus)
lrrc41 [cytosol]
(Xenopus tropicalis)
LRRC41 [cytosol]
(Bos taurus)
LRRC41 [cytosol]
(Canis familiaris)
LRRC41 [cytosol]
(Gallus gallus)
LRRC41 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_006360.3
OpenTargets
ENSG00000132128
HPA
ENSG00000132128-LRRC41
GeneCards
Q15345
Ensembl
ENSG00000132128
,
ENST00000343304
,
ENST00000617190
,
ENSP00000477792
,
ENSP00000343298
PRO
Q15345
Pharos - Targets
Q15345
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.527
5
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