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WSB1 [cytosol]
Stable Identifier
R-HSA-976016
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WD repeat and SOCS box-containing protein 1, WSB1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6I7 WSB1
Gene Names
WSB1, SWIP1
Chain
chain:1-421
Reference Genes
BioGPS Gene:26118 WSB1
COSMIC (genes):WSB1 WSB1
CTD Gene:26118 WSB1
dbSNP Gene:26118 WSB1
ENSEMBL:ENSG00000109046.15 WSB1
HGNC:19221 WSB1
KEGG Gene (Homo sapiens):26118 WSB1
Monarch:26118 WSB1
NCBI Gene:26118 WSB1
OMIM:610091 WSB1
UCSC:Q9Y6I7 WSB1
Reference Transcript
RefSeq:XM_017024435.1 WSB1
RefSeq:XM_017024436.1 WSB1
RefSeq:NM_015626.9 WSB1
RefSeq:NM_134265.3 WSB1
Other Identifiers
0004670066
11721624_s_at
11745890_x_at
11746616_a_at
16832319
201296_PM_s_at
201296_s_at
210561_PM_s_at
210561_s_at
230267_PM_at
230267_at
26118
3715111
3715112
3715116
3715119
3715121
3715123
3715132
3715134
3715135
3715139
3715141
3715142
3715143
3715144
3715145
3715146
40928_at
45590_at
8005765
A_14_P138297
A_23_P4353
GO:0000209
GO:0005515
GO:0005622
GO:0005737
GO:0005829
GO:0008150
GO:0016567
GO:0016740
GO:0023052
GO:0035556
GO:0036211
GO:0044314
GO:0061630
GO:0140096
GO:0140454
HMNXSV003010426
HMNXSV003028221
HMNXSV003055988
Hs.43874.0.A1_3p_at
ILMN_1664802
ILMN_2415748
PH_hs_0023762
TC17000309.hg
g5817189_3p_s_at
g7661595_3p_a_at
p7255
Participates
as a member of
CUL5-box protein [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
SWiP-1 [cytosol]
(Gallus gallus)
Wsb1 [cytosol]
(Mus musculus)
Wsb1 [cytosol]
(Rattus norvegicus)
wsb1 [cytosol]
(Danio rerio)
wsb1 [cytosol]
(Xenopus tropicalis)
WSB1 [cytosol]
(Bos taurus)
WSB1 [cytosol]
(Canis familiaris)
WSB1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016879924.1
,
NP_599027.1
,
XP_016879925.1
,
NP_056441.6
OpenTargets
ENSG00000109046
GeneCards
Q9Y6I7
HPA
ENSG00000109046-WSB1
Ensembl
ENST00000262394
,
ENSP00000327055
,
ENSG00000109046
,
ENSP00000262394
,
ENST00000348811
PRO
Q9Y6I7
Pharos - Targets
Q9Y6I7
HMDB Protein
HMDBP13671
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.543
5
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.527
4
UniProt:Q9QZR5
3
monoSUMO1-K32-HIPK2 [nucleoplasm]
(R-MMU-4090405)
phospho-p-HIPK2 [nucleoplasm]
(R-MMU-6799375)
HIPK2 [nucleoplasm]
(R-MMU-3215222)
0.524
5
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