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WSB1 [cytosol]
Stable Identifier
R-HSA-976016
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WD repeat and SOCS box-containing protein 1, WSB1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
WSB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6I7 WSB1
Gene Names
WSB1, SWIP1
Chain
chain:1-421
Reference Genes
BioGPS Gene:26118 WSB1
COSMIC (genes):WSB1 WSB1
CTD Gene:26118 WSB1
dbSNP Gene:26118 WSB1
ENSEMBL:ENSG00000109046 WSB1
HGNC:19221 WSB1
KEGG:hsa:26118 WSB1
Monarch:26118 WSB1
NCBI Gene:26118 WSB1
OMIM:610091 WSB1
UCSC:Q9Y6I7 WSB1
Reference Transcript
RefSeq:XM_017024435.1 WSB1
RefSeq:NM_134265.3 WSB1
RefSeq:XM_017024436.1 WSB1
RefSeq:NM_015626.9 WSB1
Other Identifiers
11721624_s_at
11745890_x_at
11746616_a_at
11760162_at
11760163_s_at
11760501_a_at
11760502_at
16832319
201294_PM_s_at
201294_s_at
201295_PM_s_at
201295_s_at
201296_PM_s_at
201296_s_at
210561_PM_s_at
210561_s_at
230267_PM_at
230267_at
26118
3715111
3715112
3715116
3715117
3715118
3715119
3715120
3715121
3715123
3715124
3715125
3715126
3715127
3715128
3715129
3715130
3715131
3715132
3715133
3715134
3715135
3715136
3715137
3715138
3715139
3715141
3715142
3715143
3715144
3715145
3715146
40928_at
45590_at
80053_at
8005765
A_14_P138297
A_23_P4353
GE61165
GO:0000209
GO:0003824
GO:0005515
GO:0005737
GO:0005829
GO:0008150
GO:0016567
GO:0016740
GO:0035556
GO:0044314
GO:0061630
GO:0140096
GO:0140454
HMNXSV003010426
HMNXSV003028221
HMNXSV003055988
Hs.187991.0.S1_3p_a_at
Hs.187991.0.S2_3p_a_at
Hs.43874.0.A1_3p_at
ILMN_1664802
ILMN_1747759
ILMN_2415748
PH_hs_0023762
TC17000309.hg
g5817189_3p_s_at
g7661595_3p_a_at
p7255
Participates
as a member of
CUL5-box protein [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
SWiP-1 [cytosol]
(Gallus gallus)
Wsb1 [cytosol]
(Mus musculus)
wsb1 [cytosol]
(Danio rerio)
wsb1 [cytosol]
(Xenopus tropicalis)
WSB1 [cytosol]
(Bos taurus)
WSB1 [cytosol]
(Canis familiaris)
WSB1 [cytosol]
(Rattus norvegicus)
WSB1 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENSG00000109046
,
ENSP00000262394
,
ENST00000262394
,
ENST00000348811
,
ENSP00000327055
OpenTargets
ENSG00000109046
GeneCards
WSB1
HPA
ENSG00000109046-WSB1
PRO
Q9Y6I7
Pharos - Targets
Q9Y6I7
HMDB Protein
HMDBP13671
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.643
6
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.543
5
UniProt:Q9QZR5
3
monoSUMO1-K32-HIPK2 [nucleoplasm]
(R-MMU-4090405)
HIPK2 [nucleoplasm]
(R-MMU-3215222)
phospho-p-HIPK2 [nucleoplasm]
(R-MMU-6799375)
0.524
5
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