Reactome | COPS7A [nucleoplasm]

COPS7A [nucleoplasm]

Stable Identifier

R-HSA-5697011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

COP9 signalosome complex subunit 7a, CSN7A_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - DNA Damage Recognition in GG-NER (Homo sapiens)
      - XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
        
        COP9 signalosome [nucleoplasm] (Homo sapiens)
        
        COPS7 [nucleoplasm] (Homo sapiens)
        
        COPS7A [nucleoplasm] (Homo sapiens)
        
        UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
        
        COP9 signalosome [nucleoplasm] (Homo sapiens)
        
        COPS7 [nucleoplasm] (Homo sapiens)
        
        COPS7A [nucleoplasm] (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Formation of TC-NER Pre-Incision Complex (Homo sapiens)
      - ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
        
        COP9 signalosome [nucleoplasm] (Homo sapiens)
        
        COPS7 [nucleoplasm] (Homo sapiens)
        
        COPS7A [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
        
        COP9 signalosome [nucleoplasm] (Homo sapiens)
        
        COPS7 [nucleoplasm] (Homo sapiens)
        
        COPS7A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBW8 COPS7A

Gene Names

COPS7A, CSN7A, DERP10

Chain

initiator methionine:, chain:2-275

Reference Genes

BioGPS Gene:50813 COPS7A

COSMIC (genes):COPS7A COPS7A

CTD Gene:50813 COPS7A

dbSNP Gene:50813 COPS7A

ENSEMBL:ENSG00000111652 COPS7A

HGNC:16758 COPS7A

KEGG:hsa:50813 COPS7A

Monarch:50813 COPS7A

NCBI Gene:50813 COPS7A

OMIM:616009 COPS7A

UCSC:Q9UBW8 COPS7A

Reference Transcript

Other Identifiers

11723365_a_at

11744338_a_at

11747400_a_at

11747401_s_at

11747402_x_at

11754663_s_at

16747373

209029_PM_at

209029_at

3402698

3402699

3402700

3402701

3402702

3402703

3402704

3402706

3402707

3402708

3402709

3402710

3402711

3402712

3402713

3402714

3402715

3402716

3402717

3402718

3402719

3402720

3402721

3402722

3402723

34404_at

44842_at

50813

7953395

GE58724

GO:0000338

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0008180

GO:0010387

GO:0032991

GO:0043226

GO:0045116

GO:0065003

GO:2000434

HMNXSV003039852

ILMN_1758412

PH_hs_0022378

TC12000089.hg

g6120134_3p_at

Participates

as a member of

COPS7 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

COPS7A [cytosol]

Inferred To

CSN7 [nucleoplasm] (Drosophila melanogaster)

Cops7a [nucleoplasm] (Mus musculus)

Cops7a [nucleoplasm] (Rattus norvegicus)

COPS7A [nucleoplasm] (Bos taurus)

COPS7A [nucleoplasm] (Canis familiaris)

COPS7A [nucleoplasm] (Gallus gallus)

COPS7A [nucleoplasm] (Sus scrofa)

csn7 [nucleoplasm] (Dictyostelium discoideum)

cops7b [nucleoplasm] (Xenopus tropicalis)

csn71 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_005253751.1, NP_057403.1, NP_001157565.1, NP_001157566.1, NP_001157567.1

OpenTargets

ENSG00000111652

ENSEMBL

ENST00000534877, ENST00000534947, ENST00000229251, ENSP00000438363, ENST00000543155, ENST00000539735, ENSP00000229251, ENSP00000446039, ENSP00000438115, ENSP00000441852

HPA

ENSG00000111652-COPS7A

PRO

Q9UBW8

Pharos - Targets

Q9UBW8

GlyGen

Q9UBW8

PDB

4D10, 4WSN, 4D18

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92466 DDB2	3	DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.643	5
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	2
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	2
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.527	3
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.462	6