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SPSB2 [cytosol]
Stable Identifier
R-HSA-976048
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SPRY domain-containing SOCS box protein 2, SPSB2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SPSB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99619 SPSB2
Gene Names
SPSB2, GRCC9, SSB2
Chain
chain:1-263
Reference Genes
BioGPS Gene:84727 SPSB2
COSMIC (genes):SPSB2 SPSB2
CTD Gene:84727 SPSB2
dbSNP Gene:84727 SPSB2
ENSEMBL:ENSG00000111671 SPSB2
ENSEMBL_homo_sapiens_GENE:ENSG00000111671 SPSB2
HGNC:29522 SPSB2
KEGG Gene (Homo sapiens):84727 SPSB2
Monarch:84727 SPSB2
NCBI Gene:84727 SPSB2
OMIM:611658 SPSB2
UCSC:Q99619 SPSB2
Reference Transcript
RefSeq:NM_032641.3 SPSB2
RefSeq:NM_001146316.1 SPSB2
RefSeq:NM_001319670.1 SPSB2
Other Identifiers
0000580008
105369632
11728534_a_at
11747431_at
11757357_x_at
223580_at
3442347
3442348
3442349
3442351
3442352
3442353
3442355
3442356
3EMW
55225
5XN3
7960709
84727
A_23_P151098
A_33_P3218188
AAB51328
AAH02983
AAH71933
AAL57346
AF403027
AK297963
BAH12697
BC002983
BC071933
CCDS8567
CH471116
E5RIC2
EAW88719
EAW88720
ENSG00000111671
ENSP00000428338
ENSP00000430872
ENSP00000431037
ENST00000519357
ENST00000523102
ENST00000524270
EntrezGene:105369632
EntrezGene:84727
g12804248_3p_at
g12804248_3p_x_at
GE88591
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0007165
GO:0008150
GO:0009056
GO:0016567
GO:0019005
GO:0032991
GO:0035556
GO:0043161
GO:0043687
HGNC:29522
HPA055225
ILMN_1787541
IPR001496
IPR001870
IPR003877
IPR013320
IPR036036
IPR037340
LOC105369632
MIM:611658
NM_001146316
NM_001319670
NM_032641
NP_001139788
NP_001306599
NP_116030
PF00622
PF07525
PH_hs_0022196
SM00253
SM00449
SM00969
SPSB2
SPSB2-203
SPSB2-204
SPSB2-205
U47924
uc001qrl.4
uc001qrm.4
uc058kmu.1
UPI000003316E
UPI0000493356
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
hasMember
CUL5-box protein [cytosol]
Inferred To
Homologues of SPSB2 [cytosol] (Danio rerio)
Homologues of SPSB2 [cytosol] (Sus scrofa)
SPSB2 [cytosol] (Bos taurus)
SPSB2 [cytosol] (Canis familiaris)
SPSB2 [cytosol] (Danio rerio)
SPSB2 [cytosol] (Drosophila melanogaster)
SPSB2 [cytosol] (Mus musculus)
SPSB2 [cytosol] (Rattus norvegicus)
SPSB2 [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_001139788.1
,
NP_001306599.1
,
NP_116030.1
OpenTargets
ENSG00000111671
ZINC - Substances
SPSB2_HUMAN
GeneCards
Q99619
DOCK Blaster
3EMW
ZINC target
Q99619
PRO
Q99619
BRENDA (Homo sapiens)
3.6.4.13
,
1.14.13.39
ZINC - Predictions - Purchasable
SPSB2_HUMAN
PDB
3EMW
,
5XN3
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15369 ELOC
2
ELOC [cytosol]
(R-HSA-180535)
TCEB1 [nucleoplasm]
(R-HSA-112422)
0.564
3
UniProt:Q99873 PRMT1
1
PRMT1 [nucleoplasm]
(R-HSA-3215140)
0.508
2
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