Reactome | FEM1A [cytosol]

FEM1A [cytosol]

Stable Identifier

R-HSA-8863141

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein fem-1 homolog A, FEM1A_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        FEM1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BSK4 FEM1A

Gene Names

FEM1A, EPRAP

Chain

chain:1-669

Reference Genes

BioGPS Gene:55527 FEM1A

COSMIC (genes):FEM1A FEM1A

CTD Gene:55527 FEM1A

dbSNP Gene:55527 FEM1A

ENSEMBL:ENSG00000141965 FEM1A

ENSEMBL_homo_sapiens_GENE:ENSG00000141965.5 FEM1A

HGNC:16934 FEM1A

KEGG Gene (Homo sapiens):55527 FEM1A

Monarch:55527 FEM1A

NCBI Gene:55527 FEM1A

OMIM:613538 FEM1A

UCSC:Q9BSK4 FEM1A

Reference Transcript

RefSeq:NM_018708.2 FEM1A

Other Identifiers

11716867_at

16857254

223175_PM_s_at

223175_s_at

230853_PM_at

230853_at

3479696

3479697

3479698

3479700

3479701

3479704

3479707

3800261

3800274

3800276

3800282

3800288

3800292

3800304

3817671

3817672

3817673

3817674

3817675

3817677

3817679

3817680

3817681

3914635

3914636

55527

56346_at

73547_at

8024898

88099_at

A_14_P100409

A_24_P219920

A_24_P859032

GE62316

GE858532

GE860278

GO:0000151

GO:0005515

GO:0005737

GO:0005739

GO:0005829

GO:0006511

GO:0006954

GO:0016567

GO:0030163

GO:0031462

GO:0031867

GO:0036211

GO:0043226

GO:0050728

GO:0050729

GO:0051438

GO:0060090

GO:0140627

GO:1990756

HMNXSV003048426

Hs.239108.0.A1_3p_x_at

ILMN_1719985

PH_hs_0012890

PH_hs_0029824

TC19000096.hg

g13436427_3p_at

Participates

as a member of

CUL2-box protein [cytosol] (Homo sapiens)

Inferred To

Fem1aa [cytosol] (Mus musculus)

fem-1 [cytosol] (Caenorhabditis elegans)

Fem1a [cytosol] (Rattus norvegicus)

FEM1A [cytosol] (Bos taurus)

FEM1A [cytosol] (Canis familiaris)

FEM1A [cytosol] (Drosophila melanogaster)

FEM1A [cytosol] (Gallus gallus)

FEM1A [cytosol] (Sus scrofa)

fem1a [cytosol] (Danio rerio)

Cross References

RefSeq

NP_061178.1

OpenTargets

ENSG00000141965

HPA

ENSG00000141965-FEM1A

GeneCards

Q9BSK4

Ensembl

ENSG00000141965, ENSP00000269856, ENST00000269856

PRO

Q9BSK4

Pharos - Targets

Q9BSK4

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14561 NDUFAB1	4	Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586) PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) octanoyl-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-9857608) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925)	0.556	3
UniProt:P09110 ACAA1	6	ACAA1(1-26) [peroxisomal matrix] (R-HSA-9033534) ACAA1(1-424) [peroxisomal matrix] (R-HSA-9033517) ACAA1(1-424) [cytosol] (R-HSA-9033127) ACAA1 [extracellular region] (R-HSA-6799680) ACAA1 [specific granule lumen] (R-HSA-6799608) ACAA1 [peroxisomal matrix] (R-HSA-390238)	0.556	3
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	2