Reactome | METAP2 [cytosol]

METAP2 [cytosol]

Stable Identifier

R-HSA-2534094

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Methionine aminopeptidase 2, AMPM2_HUMAN

Locations in the PathwayBrowser

Expand all

Sensory Perception (Homo sapiens)

- Visual phototransduction (Homo sapiens)
  - The phototransduction cascade (Homo sapiens)
    - Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
      - METAP1/2 demethylates GNAT1 (Homo sapiens)
        
        METAP1/2 [cytosol] (Homo sapiens)
        
        METAP2:2Co2+ [cytosol] (Homo sapiens)
        
        METAP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50579 METAP2

Gene Names

METAP2, MNPEP, P67EIF2

Chain

initiator methionine:, chain:2-478

Reference Genes

BioGPS Gene:10988 METAP2

COSMIC (genes):METAP2 METAP2

CTD Gene:10988 METAP2

dbSNP Gene:10988 METAP2

ENSEMBL:ENSG00000111142 METAP2

HGNC:16672 METAP2

Monarch:10988 METAP2

NCBI Gene:10988 METAP2

OMIM:601870 METAP2

UCSC:P50579 METAP2

Reference Transcript

Other Identifiers

10988

11716176_s_at

11716177_a_at

11755477_a_at

16755269

209861_PM_s_at

209861_s_at

213899_PM_at

213899_at

227993_PM_at

227993_at

240769_PM_at

240769_at

244185_PM_at

244185_at

3426918

3426919

3426920

3426921

3426922

3426923

3426924

3426925

3426927

3426928

3426929

3426932

3426933

3426934

3426935

3426938

3426940

3426941

3426943

3426944

3426945

3426946

3426947

3426948

3426949

3426971

3426973

3426975

37699_at

42989_at

7957633

82674_at

91773_at

A_14_P136440

A_23_P99260

A_24_P141736

GE59063

GO:0003723

GO:0003824

GO:0004177

GO:0004239

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0008235

GO:0016485

GO:0016787

GO:0018206

GO:0031365

GO:0046872

GO:0051604

GO:0070006

GO:0140096

HMNXSV003038698

Hs.129124.0.A1_3p_at

Hs.144906.0.A1_3p_at

Hs.78935.3.A1_3p_at

ILMN_1670420

ILMN_1876758

PH_hs_0016792

PH_hs_0022591

TC12000738.hg

g687242_3p_a_at

Participates

as a component of

METAP2:2Co2+ [cytosol] (Homo sapiens)

Inferred To

METAP2 [cytosol] (Bos taurus)

METAP2 [cytosol] (Canis familiaris)

METAP2 [cytosol] (Danio rerio)

METAP2 [cytosol] (Dictyostelium discoideum)

METAP2 [cytosol] (Mus musculus)

METAP2 [cytosol] (Rattus norvegicus)

METAP2 [cytosol] (Saccharomyces cerevisiae)

METAP2 [cytosol] (Schizosaccharomyces pombe)

METAP2 [cytosol] (Sus scrofa)

METAP2 [cytosol] (Xenopus tropicalis)

Cross References

ZINC - World Drugs

MAP2_HUMAN

Guide to Pharmacology - Targets

1573

OpenTargets

ENSG00000111142

ENSEMBL

ENST00000323666, ENSP00000261220, ENSP00000448169, ENST00000261220, ENSP00000325312, ENST00000546753

ZINC - FDA approved

MAP2_HUMAN

ZINC - Substances

MAP2_HUMAN

ZINC - Biogenic

MAP2_HUMAN

ZINC target

P50579

PRO

P50579

GlyGen

P50579

PDB

8ONY, 2EA4, 1R58, 2GA2, 2EA2, 1R5H, 1R5G, 1BOA, 2ADU, 7A12, 5JI6, 6QED, 5JHU, 1KQ9, 6QEJ, 5JFR, 2OAZ, 5LYW, 5D6E, 7A15, 6QEI, 7A16, 1KQ0, 5D6F, 8OXG, 7A14, 6QEG, 5CLS, 6QEF, 7A13, 1B59, 1BN5, 1B6A, 1YW7, 1YW9, 5LYX, 1YW8, 1QZY, 6QEH

ZINC - Investigational

MAP2_HUMAN

ZINC - Metabolites

MAP2_HUMAN

IntEnz

3.4.11.18

HPA

ENSG00000111142-METAP2

Pharos - Targets

P50579

ZINC - Predictions - Purchasable

MAP2_HUMAN

HMDB Protein

HMDBP08234

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	2
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	2