Reactome | CD74(1-117) [lysosomal membrane]

CD74(1-117) [lysosomal membrane]

Stable Identifier

R-HSA-2130632

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

lip10, Invariant chain (Ii), Leupeptin induced invariant chain peptide 10

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04233 CD74

Gene Names

CD74, DHLAG

Chain

chain:1-296, peptide:97-120

Reference Genes

BioGPS Gene:972 CD74

COSMIC (genes):CD74 CD74

CTD Gene:972 CD74

dbSNP Gene:972 CD74

ENSEMBL:ENSG00000019582 CD74

HGNC:1697 CD74

KEGG:hsa:972 CD74

Monarch:972 CD74

NCBI Gene:972 CD74

OMIM:142790 CD74

UCSC:P04233 CD74

Reference Transcript

Participates

as a component of

lip10 trimer [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

CD74 [plasma membrane]

CD74 [lysosomal membrane]

CD74(1-176) [lysosomal membrane]

CD74 [endocytic vesicle membrane]

CD74 [clathrin-coated endocytic vesicle membrane]

CD74 [transport vesicle membrane]

CD74 [trans-Golgi network membrane]

CD74 [Golgi membrane]

CD74 [ER to Golgi transport vesicle membrane]

CD74 [lumenal side of endoplasmic reticulum membrane]

CD74(81-104) [lysosomal membrane]

CD74(81-104) [lysosomal lumen]

Inferred To

CD74 [lysosomal membrane] (Bos taurus)

CD74 [lysosomal membrane] (Canis familiaris)

CD74 [lysosomal membrane] (Sus scrofa)

cd74a [lysosomal membrane] (Danio rerio)

Cd74 [lysosomal membrane] (Mus musculus)

Cd74 [lysosomal membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001020329.1, NP_004346.1, NP_001020330.1

Guide to Pharmacology - Targets

2840

OpenTargets

ENSG00000019582

ENSEMBL

ENSP00000230685, ENST00000009530, ENST00000353334, ENSG00000019582, ENSP00000367026, ENSP00000009530, ENST00000377795

ZINC - Substances

HG2A_HUMAN

ZINC target

P04233

PRO

P04233

GlyGen

P04233

PDB

1A6A, 4AEN, 3PGC, 3PDO, 9CYM, 9CYL, 8VSP, 7YXB, 7Z0Q, 4AH2, 7YX9, 1ICF, 8VSJ, 3QXA, 8VRW, 4X5W, 3QXD, 1IIE, 5KSV, 3PGD, 1L3H, 1MUJ, 5KSU

HPA

ENSG00000019582-CD74

GeneCards

CD74

Pharos - Targets

P04233

ZINC - Predictions - Purchasable

HG2A_HUMAN

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01903 HLA-DRA	9	HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane] (R-HSA-197588) HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane] (R-HSA-2130677) HLA class II histocompatibility antigen, DR alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130463) HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130442) HLA class II histocompatibility antigen, DR alpha chain precursor [transport vesicle membrane] (R-HSA-2130530) HLA class II histocompatibility antigen, DR alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130586) HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane] (R-HSA-2214390) HLA class II histocompatibility antigen, DR alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130480) HLA class II histocompatibility antigen, DR alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130665)	0.564	2
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.556	4
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.547	2
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.544	3
UniProt:P0A6Y8 DNAK			0.544	8
UniProt:P01909 HLA-DQA1	9	HLA class II histocompatibility antigen, DQ [plasma membrane] (R-HSA-197585) HLA class II histocompatibility antigen, DQ [lysosomal membrane] (R-HSA-2130686) HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] (R-HSA-2130529) HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane] (R-HSA-2130595) HLA class II histocompatibility antigen, DQ [transport vesicle membrane] (R-HSA-2130733) HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] (R-HSA-2130568) HLA class II histocompatibility antigen, DQ [Golgi membrane] (R-HSA-2214382) HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane] (R-HSA-2130699) HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130716)	0.536	2
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.527	2
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [Golgi membrane] (R-HSA-6808747) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987)	0.527	2
UniProt:P04440 HLA-DPB1	9	HLA class II histocompatibility antigen, DP [plasma membrane] (R-HSA-197648) HLA class II histocompatibility antigen, DP [lysosomal membrane] (R-HSA-2130601) HLA class II histocompatibility antigen, DP [endocytic vesicle membrane] (R-HSA-2130419) HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane] (R-HSA-2130390) HLA class II histocompatibility antigen, DP [transport vesicle membrane] (R-HSA-2130533) HLA class II histocompatibility antigen, DP [trans-Golgi network membrane] (R-HSA-2130397) HLA class II histocompatibility antigen, DP [Golgi membrane] (R-HSA-2214364) HLA class II histocompatibility antigen, DP [ER to Golgi transport vesicle membrane] (R-HSA-2130688) HLA class II histocompatibility antigen, DP [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130709)	0.527	2
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.527	2
UniProt:P25025 CXCR2	2	CXCR2 [plasma membrane] (R-HSA-373796) CXCR2 [secretory granule membrane] (R-HSA-6804771)	0.524	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.499	2
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.499	2
UniProt:P16070 CD44	2	CD44 [plasma membrane] (R-HSA-1031688) CD44 [secretory granule membrane] (R-HSA-6804776)	0.463	9

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