Reactome | SLC27A2 [peroxisomal membrane]

SLC27A2 [peroxisomal membrane]

Stable Identifier

R-HSA-389579

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

Very long-chain acyl-CoA synthetase, VLCS

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O14975 SLC27A2

Gene Names

SLC27A2, ACSVL1, FACVL1, FATP2, VLACS

Chain

chain:1-620

Reference Genes

BioGPS Gene:11001 SLC27A2

COSMIC (genes):SLC27A2 SLC27A2

CTD Gene:11001 SLC27A2

dbSNP Gene:11001 SLC27A2

ENSEMBL:ENSG00000140284 SLC27A2

HGNC:10996 SLC27A2

KEGG:hsa:11001 SLC27A2

Monarch:11001 SLC27A2

NCBI Gene:11001 SLC27A2

OMIM:603247 SLC27A2

UCSC:O14975 SLC27A2

Reference Transcript

Other Identifiers

11001

11718213_a_at

16800962

205768_PM_s_at

205768_s_at

205769_PM_at

205769_at

3593577

3593578

3593579

3593580

3593581

3593582

3593583

3593584

3593589

3593590

3593591

3593592

3593593

3593595

3593596

3593597

3593598

37485_at

7983650

A_14_P100855

A_23_P140450

GE61386

GO:0000038

GO:0001561

GO:0001676

GO:0003824

GO:0004467

GO:0005215

GO:0005324

GO:0005524

GO:0005777

GO:0005778

GO:0005783

GO:0005788

GO:0005789

GO:0005829

GO:0005886

GO:0006629

GO:0006631

GO:0006635

GO:0006699

GO:0006790

GO:0006869

GO:0008206

GO:0015245

GO:0015908

GO:0016020

GO:0016874

GO:0019899

GO:0031957

GO:0035579

GO:0042760

GO:0043226

GO:0044539

GO:0046949

GO:0047676

GO:0047747

GO:0050197

GO:0055086

GO:0070062

GO:0070251

GO:0097089

GO:0140657

GO:1901135

GO:1901480

HMNXSV003027973

ILMN_1700831

PH_hs_0001112

TC15000391.hg

g4503652_3p_at

Participates

as a member of

Cargo proteins containing PTS1 [peroxisomal matrix] (Homo sapiens)

Other forms of this molecule

SLC27A2 [cytosol]

SLC27A2 [endoplasmic reticulum membrane]

SLC27A2 [plasma membrane]

SLC27A2 [specific granule membrane]

Inferred To

Fatp2 [peroxisomal membrane] (Drosophila melanogaster)

Fatp3 [peroxisomal membrane] (Drosophila melanogaster)

Homologues of SLC27A2 [peroxisomal membrane] (Caenorhabditis elegans)

Homologues of SLC27A2 [peroxisomal membrane] (Drosophila melanogaster)

Fatp1 [peroxisomal membrane] (Drosophila melanogaster)

slc27a3 [peroxisomal membrane] (Xenopus tropicalis)

acs-22 [peroxisomal membrane] (Caenorhabditis elegans)

acs-20 [peroxisomal membrane] (Caenorhabditis elegans)

SLC27A2 [peroxisomal membrane] (Bos taurus)

SLC27A2 [peroxisomal membrane] (Canis familiaris)

SLC27A2 [peroxisomal membrane] (Gallus gallus)

SLC27A2 [peroxisomal membrane] (Mus musculus)

SLC27A2 [peroxisomal membrane] (Rattus norvegicus)

SLC27A2 [peroxisomal membrane] (Saccharomyces cerevisiae)

SLC27A2 [peroxisomal membrane] (Sus scrofa)

Cross References

RefSeq

NP_001153101.1, NP_003636.2

Guide to Pharmacology - Targets

1109

ENSEMBL

ENST00000380902, ENSP00000370289, ENSP00000267842, ENST00000267842

OpenTargets

ENSG00000140284

HPA

ENSG00000140284-SLC27A2

PRO

O14975

Pharos - Targets

O14975

GlyGen

O14975

HMDB Protein

HMDBP01946

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14314 PRKCSH	3	PRKCSH [plasma membrane] (R-HSA-879405) p-PRKCSH [endoplasmic reticulum lumen] (R-HSA-8956890) PRKCSH [endoplasmic reticulum lumen] (R-HSA-532666)	0.527	2
UniProt:O60518 RNBP6			0.527	4
UniProt:Q8N128 F177A			0.527	3
UniProt:P0DTD1-PRO_0000449620 REP			0.527	2
UniProt:Q92843 B2CL2			0.527	3
UniProt:Q9BQ48 MRPL34	1	MRPL34 [mitochondrial inner membrane] (R-HSA-5368205)	0.527	2
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	2
UniProt:Q9BV87 CNPD1			0.527	2
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.527	3
UniProt:O60443 GSDME	18	GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) G199E [cytosol] (R-HSA-9710427)	0.527	2
UniProt:Q8NF37 LPCAT1	3	LPCAT1 [plasma membrane] (R-HSA-6806273) LPCAT1 [azurophil granule membrane] (R-HSA-6798758) LPCAT1 [endoplasmic reticulum membrane] (R-HSA-1498772)	0.527	3

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