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PLCD1 [plasma membrane]
Stable Identifier
R-HSA-2023880
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
PLCdegh [plasma membrane] (Homo sapiens)
PLCD1:Ca2+ [plasma membrane] (Homo sapiens)
PLCD1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51178 PLCD1
Gene Names
PLCD1
Chain
chain:1-756
Reference Genes
BioGPS Gene:5333 PLCD1
COSMIC (genes):PLCD1 PLCD1
CTD Gene:5333 PLCD1
dbSNP Gene:5333 PLCD1
ENSEMBL:ENSG00000187091 PLCD1
HGNC:9060 PLCD1
KEGG:hsa:5333 PLCD1
Monarch:5333 PLCD1
NCBI Gene:5333 PLCD1
OMIM:602142 PLCD1
UCSC:P51178 PLCD1
Reference Transcript
RefSeq:NM_006225.4 PLCD1
RefSeq:NM_001130964.2 PLCD1
Other Identifiers
11718816_a_at
16952218
205125_PM_at
205125_at
2669489
2669490
2669491
2669492
2669493
2669494
2669495
2669496
2669497
2669498
2669499
2669500
2669501
2669502
2669503
2669504
2669505
2669506
2669507
2669508
2669509
2669510
2669511
2669512
2669516
2669517
2669519
2669520
2669521
2669522
2669523
2669524
2669526
2669527
2669528
37596_at
5333
8086185
A_23_P80739
GE58900
GO:0001786
GO:0003824
GO:0004435
GO:0004629
GO:0005509
GO:0005515
GO:0005546
GO:0005737
GO:0005886
GO:0006629
GO:0006644
GO:0007165
GO:0008081
GO:0008289
GO:0016042
GO:0016787
GO:0032794
GO:0035556
GO:0043226
GO:0046488
GO:0046872
GO:0070062
GO:0070300
GO:0141212
GO:1901981
HMNXSV003034892
ILMN_1769394
PH_hs_0027710
TC03001292.hg
TC03002861.hg
U09117_at
g5453909_3p_at
Participates
as a component of
PLCD1:Ca2+ [plasma membrane] (Homo sapiens)
Inferred To
plc-3 [plasma membrane]
(Caenorhabditis elegans)
plcd1 [plasma membrane]
(Xenopus tropicalis)
plc [plasma membrane]
(Dictyostelium discoideum)
PLC1 [plasma membrane]
(Saccharomyces cerevisiae)
plc1 [plasma membrane]
(Schizosaccharomyces pombe)
Plcd1 [plasma membrane]
(Mus musculus)
Plcd1 [plasma membrane]
(Rattus norvegicus)
plcd1a [plasma membrane]
(Danio rerio)
PLCD1 [plasma membrane]
(Bos taurus)
PLCD1 [plasma membrane]
(Canis familiaris)
PLCD1 [plasma membrane]
(Gallus gallus)
PLCD1 [plasma membrane]
(Plasmodium falciparum)
PLCD1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001124436.1
,
NP_006216.2
Guide to Pharmacology - Targets
1409
ENSEMBL
ENSG00000187091
,
ENST00000334661
,
ENST00000463876
,
ENSP00000335600
,
ENSP00000430344
OpenTargets
ENSG00000187091
ZINC - Substances
PLCD1_HUMAN
ZINC target
P51178
PRO
P51178
GlyGen
P51178
IntEnz
3.1.4.11
GeneCards
PLCD1
HPA
ENSG00000187091-PLCD1
Pharos - Targets
P51178
Orphanet
PLCD1
ZINC - Predictions - Purchasable
PLCD1_HUMAN
HMDB Protein
HMDBP00247
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14974 KPNB1
5
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
0.602
4
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
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