Reactome | sBAFF [extracellular region]

sBAFF [extracellular region]

Stable Identifier

R-HSA-5676541

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

sTNFSF13B, soluble BAFF, Tumor necrosis factor ligand superfamily member 13B, TN13B_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
    - Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
      - TRAF3 binds BAFFR:BAFF (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
        
        3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
      - sBAFF trimer binds BAFFR (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
    - TNFs bind their physiological receptors (Homo sapiens)
      - sBAFF,sAPRIL binds TACI,BCMA (Homo sapiens)
        
        sBAFF,sAPRIL trimers [extracellular region] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
        
        sBAFF,sAPRIL:3xTAC1,BCMA [plasma membrane] (Homo sapiens)
        
        sBAFF,sAPRIL trimers [extracellular region] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xBAFFR:BAFF trimer [plasma membrane] (Homo sapiens)
        
        sBAFF trimer [extracellular region] (Homo sapiens)
        
        sBAFF [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y275 TNFSF13B

Gene Names

TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738

Chain

chain:1-285, chain:134-285

Reference Genes

BioGPS Gene:10673 TNFSF13B

COSMIC (genes):TNFSF13B TNFSF13B

CTD Gene:10673 TNFSF13B

dbSNP Gene:10673 TNFSF13B

ENSEMBL:ENSG00000102524 TNFSF13B

HGNC:11929 TNFSF13B

KEGG:hsa:10673 TNFSF13B

Monarch:10673 TNFSF13B

NCBI Gene:10673 TNFSF13B

OMIM:603969 TNFSF13B

UCSC:Q9Y275 TNFSF13B

Reference Transcript

Other Identifiers

10673

11727565_a_at

11756867_a_at

16776339

223501_PM_at

223501_at

223502_PM_s_at

223502_s_at

3500790

3500792

3500793

3500794

3500795

3500796

3500797

3500798

3500799

3500802

3500807

3500808

3500809

3500810

3500811

3500812

53773_at

7969986

84765_at

A_23_P14174

GE61368

GE81653

GO:0001782

GO:0002333

GO:0002376

GO:0002467

GO:0002636

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005886

GO:0005925

GO:0006955

GO:0007154

GO:0007165

GO:0016020

GO:0023052

GO:0030154

GO:0030183

GO:0030890

GO:0031295

GO:0031296

GO:0033209

GO:0042098

GO:0042100

GO:0042102

GO:0043226

GO:0043231

GO:0043588

GO:0048018

GO:0048471

GO:0048856

GO:0050776

GO:0098772

HMNXSV003037308

HMNXSV003039417

Hs.270737.0.S2_3p_at

ILMN_1758418

ILMN_2066858

PH_hs_0013929

TC13000383.hg

g7330729_3p_a_at

Participates

as a component of

sBAFF trimer [extracellular region] (Homo sapiens)

Inferred To

BAFF [extracellular region] (Gallus gallus)

Tnfsf13b [extracellular region] (Mus musculus)

Tnfsf13b [extracellular region] (Rattus norvegicus)

TNFSF13B [extracellular region] (Bos taurus)

TNFSF13B [extracellular region] (Canis familiaris)

TNFSF13B [extracellular region] (Sus scrofa)

tnfsf13b [extracellular region] (Danio rerio)

tnfsf13b [extracellular region] (Xenopus tropicalis)

egr [extracellular region] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000365048, ENSG00000102524, ENSP00000389540, ENST00000542136, ENST00000430559, ENST00000375887, ENSP00000445334

OpenTargets

ENSG00000102524

GeneCards

TNFSF13B

HPA

ENSG00000102524-TNFSF13B

PRO

Q9Y275

Pharos - Targets

Q9Y275

GlyGen

Q9Y275

PDB

1OQE, 1KD7, 1KXG, 4V46, 3V56, 5Y9J, 1JH5, 6FXN, 1OQD, 4ZCH, 1OSG

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.643	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.527	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.499	2

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