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KPNA1 [nucleoplasm]
Stable Identifier
R-HSA-188865
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Karyopherin alpha
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of phagosomal maturation (Homo sapiens)
Inhibition of nitric oxide production (Homo sapiens)
PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus (Homo sapiens)
PPE2:KPNA1:KPNB1 [nucleoplasm] (Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
PPE2:KPNA1:KPNB1 translocates to the nucleus (Homo sapiens)
PPE2:KPNA1:KPNB1 [nucleoplasm] (Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Release of NS1 homodimer (Homo sapiens)
Importin [nucleoplasm] (Homo sapiens)
Importin alpha [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
NS1 homodimer:Importin [nucleoplasm] (Homo sapiens)
Importin [nucleoplasm] (Homo sapiens)
Importin alpha [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
NS1 homodimer:Importin [nucleoplasm] (Homo sapiens)
Importin [nucleoplasm] (Homo sapiens)
Importin alpha [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Transport of Ribonucleoproteins into the Host Nucleus (Homo sapiens)
Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)
RNP:Karyopherin alpha:Karyopherin beta complex [nucleoplasm] (Homo sapiens)
RNP Complex:Karyopherin alpha [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Release of the RNP into the host cell nucleus (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
RNP:Karyopherin alpha:Karyopherin beta complex [nucleoplasm] (Homo sapiens)
RNP Complex:Karyopherin alpha [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
NS1 homodimer:Importin [nucleoplasm] (Homo sapiens)
Importin [nucleoplasm] (Homo sapiens)
Importin alpha [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptosis induced DNA fragmentation (Homo sapiens)
DFF dissociates from importin-alpha:importin-beta (Homo sapiens)
DFF:associated with the importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Translocation of DFF to the nucleus (Homo sapiens)
DFF:associated with the importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52294 KPNA1
Gene Names
KPNA1, RCH2
Chain
initiator methionine:1, chain:1-538, chain:2-538
Reference Genes
BioGPS Gene:3836 KPNA1
COSMIC (genes):KPNA1 KPNA1
CTD Gene:3836 KPNA1
dbSNP Gene:3836 KPNA1
ENSEMBL:ENSG00000114030 KPNA1
HGNC:6394 KPNA1
KEGG Gene (Homo sapiens):3836 KPNA1
Monarch:3836 KPNA1
NCBI Gene:3836 KPNA1
OMIM:600686 KPNA1
UCSC:P52294 KPNA1
Reference Transcript
RefSeq:NM_002264.3 KPNA1
RefSeq:XM_005247437.3 KPNA1
Other Identifiers
11734667_a_at
11734668_at
11734669_at
11734670_at
11734671_a_at
16958100
202055_at
202056_at
202057_at
202058_s_at
202059_s_at
213741_s_at
2691984
2691985
2691986
2691987
2691988
2691989
2691990
2691991
2691992
2691993
2691994
2691995
2691996
2691997
2691998
2691999
2692000
2692001
2692002
2692003
2692006
2692007
2692010
2692013
2692020
2692021
2692022
2692023
2692024
2692026
2692027
2692038
2692039
2692040
2692045
2692056
2692057
2692058
2692059
3836
40474_r_at
78107_at
8089999
A_33_P3214879
GE58808
GO:0000018
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006309
GO:0006606
GO:0006607
GO:0006810
GO:0006913
GO:0007165
GO:0007267
GO:0008139
GO:0008150
GO:0008219
GO:0009056
GO:0015031
GO:0016032
GO:0019054
GO:0030425
GO:0032991
GO:0034641
GO:0034655
GO:0042025
GO:0043226
GO:0044403
GO:0061608
GO:0075733
GO:0098978
GO:0099527
Hs.169149.0.S3_3p_at
Hs.169149.0.S4_3p_at
Hs.169149.0.S5_3p_at
Hs.169149.1.S1_3p_x_at
ILMN_1676005
PH_hs_0031932
S75295_at
TC03001704.hg
TC03003052.hg
g12803140_3p_a_at
g4504894_3p_a_at
Participant Of
hasMember
Importin alpha [nucleoplasm]
output
Release of the RNP into the host cell nucleus
hasComponent
importin-alpha:importin-beta complex [nucleoplasm]
RNP Complex:Karyopherin alpha [nucleoplasm]
Other forms of this molecule
KPNA1 [cytosol]
Inferred To
Ghost homologue of KPNA1 [nucleoplasm] (Bos taurus)
Kpna1 [nucleoplasm] (Mus musculus)
Kpna1 [nucleoplasm] (Rattus norvegicus)
KPNA1 [nucleoplasm] (Canis familiaris)
KPNA1 [nucleoplasm] (Gallus gallus)
KPNA1 [nucleoplasm] (Sus scrofa)
kpna1 [nucleoplasm] (Danio rerio)
kpna1 [nucleoplasm] (Xenopus tropicalis)
Kap-alpha1 [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_002255.3
,
XP_005247494.1
OpenTargets
ENSG00000114030
GeneCards
P52294
HPA
ENSG00000114030-KPNA1
Ensembl
ENSG00000114030
,
ENSP00000343701
,
ENST00000344337
PRO
P52294
Orphanet
24660
HMDB Protein
HMDBP08456
PDB
4B18
,
2JDQ
,
3TJ3
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKX7 NUP50
1
NUP50 [nucleoplasm]
(R-HSA-157740)
0.831
8
UniProt:Q92688 AN32B
0.788
8
UniProt:Q14974 KPNB1
5
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.688
3
UniProt:P31345 PB2
0.683
3
UniProt:P20700 LMNB1
8
LMNB1 [nucleoplasm]
(R-HSA-264867)
LMNB1 [cytosol]
(R-HSA-2995384)
p-S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5228738)
p-S23, S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5229018)
LMNB1(1-231) [nuclear envelope]
(R-HSA-352244)
LMNB1(232-586) [nuclear envelope]
(R-HSA-352248)
LMNB1(2-586) [nuclear envelope]
(R-HSA-912402)
p-S23,S393-LMNB1 [nucleoplasm]
(R-HSA-8868341)
0.666
4
UniProt:Q16594 TAF9
1
TAF9 [nucleoplasm]
(R-HSA-212452)
0.666
4
UniProt:P52298 NCBP2
2
NCBP2 [cytosol]
(R-HSA-162458)
NCBP2 [nucleoplasm]
(R-HSA-51463)
0.643
3
UniProt:P42224 STAT1
7
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
0.623
4
UniProt:O94782 USP1
3
USP1(672-785) [nucleoplasm]
(R-HSA-5655474)
USP1(1-671) [nucleoplasm]
(R-HSA-5655484)
USP1 [nucleoplasm]
(R-HSA-419546)
0.564
2
UniProt:K9N643 ORF4B
0.564
3
UniProt:Q9BUI4 POLR3C
2
POLR3C [cytosol]
(R-HSA-1964448)
POLR3C [nucleoplasm]
(R-HSA-1964430)
0.556
3
UniProt:Q9HAN9 NMNAT1
1
NMNAT1 [nucleoplasm]
(R-HSA-200484)
0.556
3
UniProt:Q9BQ69 MACD1
0.556
3
UniProt:Q9HAZ1 CLK4
0.556
3
UniProt:Q05322 VP24
0.527
3
UniProt:P03211 EBNA1
0.524
2
UniProt:Q5TAQ9 DCAF8
1
DCAF8 [nucleoplasm]
(R-HSA-8955192)
0.524
2
UniProt:Q13255 GRM1
2
GRM1 [plasma membrane]
(R-HSA-420521)
GRM1 [plasma membrane]
(R-HSA-6794252)
0.524
2
UniProt:P15918 RAG1
1
RAG1 [nucleoplasm]
(R-HSA-5692681)
0.508
2
UniProt:Q9WMX2-PRO_0000037548
0.508
2
UniProt:B4URF7 B4URF7
0.508
2
UniProt:P02545 LMNA
3
LMNA-RAF1 fusion [cytosol]
(R-HSA-6802399)
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
p-LMNA-RAF1 fusion [cytosol]
(R-HSA-6802537)
0.462
3
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