Reactome | KPNA1 [nucleoplasm]

KPNA1 [nucleoplasm]

Stable Identifier

R-HSA-188865

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Karyopherin alpha

Locations in the PathwayBrowser

Expand all

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Assembly of the ORC complex at the origin of replication (Homo sapiens)
      - ORC6 translocates to the nucleus (Homo sapiens)
        
        KPNA1,KPNA6:KPNB1 [nucleoplasm] (Homo sapiens)
        
        KPNA1,KPNA6 [nucleoplasm] (Homo sapiens)
        
        KPNA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52294 KPNA1

Gene Names

KPNA1, RCH2

Chain

initiator methionine:1, chain:1-538, chain:2-538

Reference Genes

BioGPS Gene:3836 KPNA1

COSMIC (genes):KPNA1 KPNA1

CTD Gene:3836 KPNA1

dbSNP Gene:3836 KPNA1

ENSEMBL:ENSG00000114030 KPNA1

ENSEMBL:ENSG00000114030.13 KPNA1

HGNC:6394 KPNA1

KEGG Gene (Homo sapiens):3836 KPNA1

Monarch:3836 KPNA1

NCBI Gene:3836 KPNA1

OMIM:600686 KPNA1

UCSC:P52294 KPNA1

Reference Transcript

Other Identifiers

11734667_a_at

11734668_at

11734669_at

11734670_at

11734671_a_at

16958100

202055_PM_at

202055_at

202056_PM_at

202056_at

202057_PM_at

202057_at

202058_PM_s_at

202058_s_at

202059_PM_s_at

202059_s_at

213741_PM_s_at

213741_s_at

2691984

2691985

2691986

2691987

2691988

2691989

2691990

2691991

2691992

2691993

2691994

2691995

2691996

2691997

2691998

2691999

2692000

2692001

2692002

2692003

2692006

2692007

2692010

2692013

2692020

2692021

2692022

2692023

2692024

2692026

2692027

2692038

2692039

2692040

2692045

2692056

2692057

2692058

2692059

3836

40474_r_at

78107_at

8089999

A_33_P3214879

GE58808

GO:0000018

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006310

GO:0006606

GO:0006607

GO:0006886

GO:0006913

GO:0008139

GO:0012501

GO:0014069

GO:0014841

GO:0014901

GO:0015031

GO:0023052

GO:0030425

GO:0042564

GO:0042981

GO:0043226

GO:0043403

GO:0048856

GO:0060828

GO:0061608

GO:0098978

GO:0099527

GO:0140104

HMNXSV003023032

Hs.169149.0.S3_3p_at

Hs.169149.0.S4_3p_at

Hs.169149.0.S5_3p_at

Hs.169149.1.S1_3p_x_at

ILMN_1676005

PH_hs_0031932

S75295_at

TC03001704.hg

TC03003052.hg

g12803140_3p_a_at

g4504894_3p_a_at

Participates

as an output of

as a component of

as a member of

Other forms of this molecule

KPNA1 [cytosol]

Inferred To

Homologues of KPNA1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of KPNA1 [nucleoplasm] (Schizosaccharomyces pombe)

ima-1 [nucleoplasm] (Caenorhabditis elegans)

imp1 [nucleoplasm] (Schizosaccharomyces pombe)

Kpna1 [nucleoplasm] (Mus musculus)

Kpna1 [nucleoplasm] (Rattus norvegicus)

KPNA1 [nucleoplasm] (Bos taurus)

KPNA1 [nucleoplasm] (Caenorhabditis elegans)

KPNA1 [nucleoplasm] (Canis familiaris)

KPNA1 [nucleoplasm] (Danio rerio)

KPNA1 [nucleoplasm] (Gallus gallus)

KPNA1 [nucleoplasm] (Sus scrofa)

kpna1 [nucleoplasm] (Xenopus tropicalis)

Kap-alpha1 [nucleoplasm] (Drosophila melanogaster)

cut15 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002255.3, XP_005247494.1

OpenTargets

ENSG00000114030

HPA

ENSG00000114030-KPNA1

GeneCards

P52294

Ensembl

ENST00000344337, ENSP00000343701, ENSG00000114030

PRO

P52294

Pharos - Targets

P52294

Orphanet

24660

HMDB Protein

HMDBP08456

PDB

6WX9, 4B18, 3TJ3, 2JDQ

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.831	8
UniProt:Q92688 AN32B			0.788	8
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714)	0.688	3
UniProt:P31345 PB2			0.683	3
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.666	4
UniProt:Q16594 TAF9	1	TAF9 [nucleoplasm] (R-HSA-212452)	0.666	4
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.643	3
UniProt:P42224 STAT1	7	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.623	4
UniProt:O94782 USP1	3	USP1 [nucleoplasm] (R-HSA-419546) USP1(672-785) [nucleoplasm] (R-HSA-5655474) USP1(1-671) [nucleoplasm] (R-HSA-5655484)	0.564	2
UniProt:K9N643 ORF4B			0.564	3
UniProt:Q9BUI4 POLR3C	2	POLR3C [cytosol] (R-HSA-1964448) POLR3C [nucleoplasm] (R-HSA-1964430)	0.556	3
UniProt:Q9HAN9 NMNAT1	1	NMNAT1 [nucleoplasm] (R-HSA-200484)	0.556	3
UniProt:Q9BQ69 MACD1			0.556	3
UniProt:Q9HAZ1 CLK4			0.556	3
UniProt:Q05322 VP24			0.527	3
UniProt:P03211 EBNA1			0.524	2
UniProt:Q13255 GRM1	2	GRM1(410-1194) [plasma membrane] (R-HSA-9737058) GRM1 [plasma membrane] (R-HSA-420521)	0.524	2
UniProt:Q5TAQ9 DCAF8	1	DCAF8 [nucleoplasm] (R-HSA-8955192)	0.524	2
UniProt:P15918 RAG1	1	RAG1 [nucleoplasm] (R-HSA-5692681)	0.508	2
UniProt:Q9WMX2-PRO_0000037548			0.508	2
UniProt:B4URF7 B4URF7			0.508	2
UniProt:Q8IUH3 RBM45			0.462	2