Reactome | CD74 [trans-Golgi network membrane]

CD74 [trans-Golgi network membrane]

Stable Identifier

R-HSA-2130493

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Synonyms

Invariant chain (Ii), HLA class II histocompatibility antigen gamma chain, HG2A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04233 CD74

Gene Names

CD74, DHLAG

Chain

chain:1-296, peptide:97-120

Reference Genes

BioGPS Gene:972 CD74

COSMIC (genes):CD74 CD74

CTD Gene:972 CD74

dbSNP Gene:972 CD74

ENSEMBL:ENSG00000019582 CD74

ENSEMBL_homo_sapiens_GENE:ENSG00000019582.17 CD74

HGNC:1697 CD74

KEGG Gene (Homo sapiens):972 CD74

Monarch:972 CD74

NCBI Gene:972 CD74

OMIM:142790 CD74

UCSC:P04233 CD74

Reference Transcript

Other Identifiers

11726254_s_at

11726255_x_at

11738435_x_at

11739401_a_at

11756766_x_at

1567628_PM_at

1567628_at

17001654

209619_PM_at

209619_at

2881376

2881377

2881378

2881379

2881380

2881381

2881384

2881386

2881387

2881391

2881393

2881396

2881398

2881400

2881401

2881407

2881408

2881409

2881410

35016_at

8115147

972

A_23_P70095

GE79594

GO:0000139

GO:0001516

GO:0001540

GO:0001934

GO:0001961

GO:0002250

GO:0002286

GO:0002376

GO:0002606

GO:0002792

GO:0002830

GO:0002906

GO:0004896

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005771

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006351

GO:0006355

GO:0006457

GO:0006629

GO:0006886

GO:0006952

GO:0006955

GO:0007155

GO:0009897

GO:0009986

GO:0010628

GO:0012501

GO:0012507

GO:0016020

GO:0016064

GO:0019882

GO:0019883

GO:0019886

GO:0019955

GO:0023026

GO:0023052

GO:0030154

GO:0030336

GO:0030658

GO:0030666

GO:0030669

GO:0030890

GO:0031394

GO:0031410

GO:0032588

GO:0032722

GO:0032755

GO:0032757

GO:0032991

GO:0033674

GO:0034341

GO:0035691

GO:0035692

GO:0035693

GO:0035718

GO:0036211

GO:0042289

GO:0042609

GO:0042613

GO:0042658

GO:0042802

GO:0043030

GO:0043066

GO:0043123

GO:0043202

GO:0043226

GO:0043410

GO:0043518

GO:0044183

GO:0045058

GO:0045059

GO:0045060

GO:0045581

GO:0045582

GO:0045657

GO:0045893

GO:0046598

GO:0048146

GO:0048856

GO:0048870

GO:0050731

GO:0050821

GO:0050998

GO:0051085

GO:0060089

GO:0060907

GO:0065003

GO:0070062

GO:0070206

GO:0070374

GO:0090023

GO:0098542

GO:0098553

GO:1902166

GO:2000343

GO:2000448

HMNXSV003053823

HMNXSV003057353

Hs2.438626.1.S1_3p_at

ILMN_1736567

ILMN_1761464

ILMN_2379644

M13560_s_at

PH_hs_0027479

TC05001936.hg

TC05003305.hg

g188469_3p_at

g188469_3p_x_at

Participates

as a component of

Invariant chain trimer [trans-Golgi network membrane] (Homo sapiens)

Other forms of this molecule

CD74(81-104) [lysosomal lumen]

CD74(81-104) [lysosomal membrane]

CD74(1-117) [lysosomal membrane]

CD74 [lumenal side of endoplasmic reticulum membrane]

CD74 [ER to Golgi transport vesicle membrane]

CD74 [Golgi membrane]

CD74 [transport vesicle membrane]

CD74 [clathrin-coated endocytic vesicle membrane]

CD74 [endocytic vesicle membrane]

CD74(1-176) [lysosomal membrane]

CD74 [lysosomal membrane]

CD74 [plasma membrane]

Inferred To

cd74a [trans-Golgi network membrane] (Danio rerio)

CD74 [trans-Golgi network membrane] (Bos taurus)

CD74 [trans-Golgi network membrane] (Canis familiaris)

CD74 [trans-Golgi network membrane] (Sus scrofa)

Ghost homologue of CD74 [trans-Golgi network membrane] (Xenopus tropicalis)

Cd74 [trans-Golgi network membrane] (Mus musculus)

Cd74 [trans-Golgi network membrane] (Rattus norvegicus)

Ii [trans-Golgi network membrane] (Gallus gallus)

Cross References

RefSeq

NP_004346.1, NP_001020329.1, NP_001020330.1

Guide to Pharmacology - Targets

2840

OpenTargets

ENSG00000019582

GeneCards

P04233

ZINC - Substances

HG2A_HUMAN

HPA

ENSG00000019582-CD74

Ensembl

ENSP00000009530, ENSG00000019582, ENST00000009530, ENSP00000230685, ENSP00000367026, ENST00000377795, ENST00000353334

ZINC target

P04233

PRO

P04233

Pharos - Targets

P04233

ZINC - Predictions - Purchasable

HG2A_HUMAN

PDB

3PGC, 1ICF, 1IIE, 1L3H, 4AH2, 7YXB, 4X5W, 1A6A, 3QXA, 7Z0Q, 4AEN, 5KSV, 5KSU, 7YX9, 3PDO, 3QXD, 3PGD, 1MUJ

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01909 HLA-DQA1	9	HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130716) HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane] (R-HSA-2130699) HLA class II histocompatibility antigen, DQ [Golgi membrane] (R-HSA-2214382) HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] (R-HSA-2130568) HLA class II histocompatibility antigen, DQ [transport vesicle membrane] (R-HSA-2130733) HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane] (R-HSA-2130595) HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] (R-HSA-2130529) HLA class II histocompatibility antigen, DQ [lysosomal membrane] (R-HSA-2130686) HLA class II histocompatibility antigen, DQ [plasma membrane] (R-HSA-197585)	0.674	4
UniProt:P01903 HLA-DRA	9	HLA class II histocompatibility antigen, DR alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130665) HLA class II histocompatibility antigen, DR alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130480) HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane] (R-HSA-2214390) HLA class II histocompatibility antigen, DR alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130586) HLA class II histocompatibility antigen, DR alpha chain precursor [transport vesicle membrane] (R-HSA-2130530) HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130442) HLA class II histocompatibility antigen, DR alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130463) HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane] (R-HSA-2130677) HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane] (R-HSA-197588)	0.564	2
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.556	4
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.547	2
UniProt:P0A6Y8 DNAK			0.544	8
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.544	3
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.527	2
UniProt:P04440 HLA-DPB1	9	HLA class II histocompatibility antigen, DP [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130709) HLA class II histocompatibility antigen, DP [ER to Golgi transport vesicle membrane] (R-HSA-2130688) HLA class II histocompatibility antigen, DP [Golgi membrane] (R-HSA-2214364) HLA class II histocompatibility antigen, DP [trans-Golgi network membrane] (R-HSA-2130397) HLA class II histocompatibility antigen, DP [transport vesicle membrane] (R-HSA-2130533) HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane] (R-HSA-2130390) HLA class II histocompatibility antigen, DP [endocytic vesicle membrane] (R-HSA-2130419) HLA class II histocompatibility antigen, DP [lysosomal membrane] (R-HSA-2130601) HLA class II histocompatibility antigen, DP [plasma membrane] (R-HSA-197648)	0.527	2
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [Golgi membrane] (R-HSA-6808747) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987)	0.527	2
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.527	2
UniProt:P25025 CXCR2	2	CXCR2 [secretory granule membrane] (R-HSA-6804771) CXCR2 [plasma membrane] (R-HSA-373796)	0.524	2
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.499	2
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.499	2
UniProt:P16070 CD44	2	CD44 [secretory granule membrane] (R-HSA-6804776) CD44 [plasma membrane] (R-HSA-1031688)	0.463	9

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