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CD74(81-104) [lysosomal membrane]
Stable Identifier
R-HSA-2130446
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
CLIP
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Disassociation of CLIP from MHC II (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
CD74(81-104) [lysosomal membrane] (Homo sapiens)
Generation of CLIP from lip10 (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
CD74(81-104) [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04233 CD74
Gene Names
CD74, DHLAG
Chain
chain:1-296, peptide:97-120
Reference Genes
BioGPS Gene:972 CD74
COSMIC (genes):CD74 CD74
CTD Gene:972 CD74
dbSNP Gene:972 CD74
ENSEMBL:ENSG00000019582 CD74
ENSEMBL_homo_sapiens_GENE:ENSG00000019582.17 CD74
HGNC:1697 CD74
KEGG Gene (Homo sapiens):972 CD74
Monarch:972 CD74
NCBI Gene:972 CD74
OMIM:142790 CD74
UCSC:P04233 CD74
Reference Transcript
RefSeq:NM_004355.3 CD74
RefSeq:NM_001025159.2 CD74
RefSeq:NM_001025158.2 CD74
Other Identifiers
11726254_s_at
11726255_x_at
11738435_x_at
11739401_a_at
11756766_x_at
1567628_PM_at
1567628_at
17001654
209619_PM_at
209619_at
2881376
2881377
2881378
2881379
2881380
2881381
2881384
2881386
2881387
2881391
2881393
2881396
2881398
2881400
2881401
2881407
2881408
2881409
2881410
35016_at
8115147
972
A_23_P70095
GE79594
GO:0000139
GO:0001516
GO:0001540
GO:0001934
GO:0001961
GO:0002250
GO:0002286
GO:0002376
GO:0002606
GO:0002792
GO:0002830
GO:0002906
GO:0004896
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005771
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006351
GO:0006355
GO:0006457
GO:0006629
GO:0006886
GO:0006952
GO:0006955
GO:0007155
GO:0009897
GO:0009986
GO:0010628
GO:0012501
GO:0012507
GO:0016020
GO:0016064
GO:0019882
GO:0019883
GO:0019886
GO:0019955
GO:0023026
GO:0023052
GO:0030154
GO:0030336
GO:0030658
GO:0030666
GO:0030669
GO:0030890
GO:0031394
GO:0031410
GO:0032588
GO:0032722
GO:0032755
GO:0032757
GO:0032991
GO:0033674
GO:0034341
GO:0035691
GO:0035692
GO:0035693
GO:0035718
GO:0036211
GO:0042289
GO:0042609
GO:0042613
GO:0042658
GO:0042802
GO:0043030
GO:0043066
GO:0043123
GO:0043202
GO:0043226
GO:0043410
GO:0043518
GO:0044183
GO:0045058
GO:0045059
GO:0045060
GO:0045581
GO:0045582
GO:0045657
GO:0045893
GO:0046598
GO:0048146
GO:0048856
GO:0048870
GO:0050731
GO:0050821
GO:0050998
GO:0051085
GO:0060089
GO:0060907
GO:0065003
GO:0070062
GO:0070206
GO:0070374
GO:0090023
GO:0098542
GO:0098553
GO:1902166
GO:2000343
GO:2000448
HMNXSV003053823
HMNXSV003057353
Hs2.438626.1.S1_3p_at
ILMN_1736567
ILMN_1761464
ILMN_2379644
M13560_s_at
PH_hs_0027479
TC05001936.hg
TC05003305.hg
g188469_3p_at
g188469_3p_x_at
Participates
as a component of
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
CD74(81-104) [lysosomal lumen]
CD74(1-117) [lysosomal membrane]
CD74 [lumenal side of endoplasmic reticulum membrane]
CD74 [ER to Golgi transport vesicle membrane]
CD74 [Golgi membrane]
CD74 [trans-Golgi network membrane]
CD74 [transport vesicle membrane]
CD74 [clathrin-coated endocytic vesicle membrane]
CD74 [endocytic vesicle membrane]
CD74(1-176) [lysosomal membrane]
CD74 [lysosomal membrane]
CD74 [plasma membrane]
Inferred To
CD74 [lysosomal membrane]
(Bos taurus)
CD74 [lysosomal membrane]
(Canis familiaris)
CD74 [lysosomal membrane]
(Sus scrofa)
cd74a [lysosomal membrane]
(Danio rerio)
Cd74 [lysosomal membrane]
(Mus musculus)
Cd74 [lysosomal membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_004346.1
,
NP_001020329.1
,
NP_001020330.1
Guide to Pharmacology - Targets
2840
OpenTargets
ENSG00000019582
GeneCards
P04233
ZINC - Substances
HG2A_HUMAN
HPA
ENSG00000019582-CD74
Ensembl
ENSP00000009530
,
ENSG00000019582
,
ENST00000009530
,
ENSP00000230685
,
ENSP00000367026
,
ENST00000377795
,
ENST00000353334
ZINC target
P04233
PRO
P04233
Pharos - Targets
P04233
ZINC - Predictions - Purchasable
HG2A_HUMAN
PDB
3PGC
,
1ICF
,
1IIE
,
1L3H
,
4AH2
,
7YXB
,
4X5W
,
1A6A
,
3QXA
,
7Z0Q
,
4AEN
,
5KSV
,
5KSU
,
7YX9
,
3PDO
,
3QXD
,
3PGD
,
1MUJ
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01909 HLA-DQA1
9
HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130716)
HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane]
(R-HSA-2130699)
HLA class II histocompatibility antigen, DQ [Golgi membrane]
(R-HSA-2214382)
HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane]
(R-HSA-2130568)
HLA class II histocompatibility antigen, DQ [transport vesicle membrane]
(R-HSA-2130733)
HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130595)
HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane]
(R-HSA-2130529)
HLA class II histocompatibility antigen, DQ [lysosomal membrane]
(R-HSA-2130686)
HLA class II histocompatibility antigen, DQ [plasma membrane]
(R-HSA-197585)
0.674
4
UniProt:P01903 HLA-DRA
9
HLA class II histocompatibility antigen, DR alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130665)
HLA class II histocompatibility antigen, DR alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130480)
HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane]
(R-HSA-2214390)
HLA class II histocompatibility antigen, DR alpha chain precursor [trans-Golgi network membrane]
(R-HSA-2130586)
HLA class II histocompatibility antigen, DR alpha chain precursor [transport vesicle membrane]
(R-HSA-2130530)
HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130442)
HLA class II histocompatibility antigen, DR alpha chain precursor [endocytic vesicle membrane]
(R-HSA-2130463)
HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane]
(R-HSA-2130677)
HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane]
(R-HSA-197588)
0.564
2
UniProt:P61073 CXCR4
1
CXCR4 [plasma membrane]
(R-HSA-2980772)
0.556
4
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.547
2
UniProt:P0A6Y8 DNAK
0.544
8
UniProt:hspa1a_hspa1b_human-1 EBI-11820565
0.544
3
UniProt:O00264 PGRMC1
2
PGRMC1 [plasma membrane]
(R-HSA-6806314)
PGRMC1 [specific granule membrane]
(R-HSA-6799648)
0.527
2
UniProt:P04440 HLA-DPB1
9
HLA class II histocompatibility antigen, DP [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130709)
HLA class II histocompatibility antigen, DP [ER to Golgi transport vesicle membrane]
(R-HSA-2130688)
HLA class II histocompatibility antigen, DP [Golgi membrane]
(R-HSA-2214364)
HLA class II histocompatibility antigen, DP [trans-Golgi network membrane]
(R-HSA-2130397)
HLA class II histocompatibility antigen, DP [transport vesicle membrane]
(R-HSA-2130533)
HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130390)
HLA class II histocompatibility antigen, DP [endocytic vesicle membrane]
(R-HSA-2130419)
HLA class II histocompatibility antigen, DP [lysosomal membrane]
(R-HSA-2130601)
HLA class II histocompatibility antigen, DP [plasma membrane]
(R-HSA-197648)
0.527
2
UniProt:Q9Y678 COPG1
4
COPG1 [endoplasmic reticulum membrane]
(R-HSA-6810960)
COPG1 [Golgi membrane]
(R-HSA-6808747)
COPG1 [transport vesicle]
(R-HSA-6808749)
COPG1 [cytosol]
(R-HSA-199987)
0.527
2
UniProt:Q9UBF2 COPG2
4
COPG2 [endoplasmic reticulum membrane]
(R-HSA-6810962)
COPG2 [Golgi membrane]
(R-HSA-6808751)
COPG2 [transport vesicle]
(R-HSA-6808753)
COPG2 [cytosol]
(R-HSA-6807747)
0.527
2
UniProt:P25025 CXCR2
2
CXCR2 [secretory granule membrane]
(R-HSA-6804771)
CXCR2 [plasma membrane]
(R-HSA-373796)
0.524
2
UniProt:P60228 EIF3E
1
EIF3E [cytosol]
(R-HSA-72552)
0.499
2
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
0.499
2
UniProt:P16070 CD44
2
CD44 [secretory granule membrane]
(R-HSA-6804776)
CD44 [plasma membrane]
(R-HSA-1031688)
0.463
9
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