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SCD [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-400117
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Acyl-CoA desaturase, ACOD_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
SCD gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
SCD [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Fatty acyl-CoA biosynthesis (Homo sapiens)
SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)
SCD dimer [endoplasmic reticulum membrane] (Homo sapiens)
SCD [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)
SCD [endoplasmic reticulum membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis (Homo sapiens)
Expression of SCD regulated by NR1H2 or NR1H3 (Homo sapiens)
SCD [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00767 SCD
Gene Names
SCD, FADS5, SCD1, SCDOS
Chain
chain:1-359
Reference Genes
BioGPS Gene:6319 SCD
COSMIC (genes):SCD SCD
CTD Gene:6319 SCD
dbSNP Gene:6319 SCD
ENSEMBL:ENSG00000099194 SCD
HGNC:10571 SCD
KEGG:hsa:6319 SCD
Monarch:6319 SCD
NCBI Gene:6319 SCD
OMIM:604031 SCD
UCSC:O00767 SCD
Reference Transcript
RefSeq:NM_005063.4 SCD
Other Identifiers
11715561_s_at
11715562_x_at
11715563_s_at
11756174_s_at
16708249
200831_PM_s_at
200831_s_at
200832_PM_s_at
200832_s_at
211162_PM_x_at
211162_x_at
211708_PM_s_at
211708_s_at
3260589
3260590
3260591
3260592
3260595
3260597
3260600
3260603
3260606
3260607
3260608
3260609
3260610
3260611
3714557
3714558
3714559
3714562
3714563
3714564
3714571
37513_at
6319
7929816
A_23_P63618
GE53772
GO:0003824
GO:0004768
GO:0005506
GO:0005515
GO:0005730
GO:0005783
GO:0005789
GO:0006629
GO:0006633
GO:0006636
GO:0016020
GO:0016491
GO:0016717
GO:0032896
GO:0043226
GO:0046872
GO:0070542
GO:0120162
GO:1903966
HMNXSV003004153
Hs.119597.0.A2_3p_a_at
ILMN_1689329
PH_hs_0041016
TC10000721.hg
TC10002246.hg
g11993936_3p_s_at
g7415720_3p_a_at
g7959734_RC_3p_s_at
Participates
as an output of
Expression of SCD regulated by NR1H2 or NR1H3 (Homo sapiens)
Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)
SCD gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
as a component of
SCD dimer [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Desat1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
SCD [endoplasmic reticulum membrane]
(Bos taurus)
SCD [endoplasmic reticulum membrane]
(Canis familiaris)
SCD [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
SCD [endoplasmic reticulum membrane]
(Gallus gallus)
SCD [endoplasmic reticulum membrane]
(Mus musculus)
SCD [endoplasmic reticulum membrane]
(Plasmodium falciparum)
SCD [endoplasmic reticulum membrane]
(Rattus norvegicus)
SCD [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
SCD [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
SCD [endoplasmic reticulum membrane]
(Sus scrofa)
fat-6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
scd [endoplasmic reticulum membrane]
(Danio rerio)
scd [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000099194
ENSEMBL
ENSP00000359380
,
ENST00000370355
ZINC - Substances
ACOD_HUMAN
ZINC target
O00767
PRO
O00767
GlyGen
O00767
PDB
4ZYO
ZINC - Investigational
ACOD_HUMAN
IntEnz
1.14.19.1
HPA
ENSG00000099194-SCD
Pharos - Targets
O00767
ZINC - Predictions - Purchasable
ACOD_HUMAN
HMDB Protein
HMDBP00313
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15393-2 TMPRSS2
0.601
4
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:P08034 GJB1
2
GJB1 [endoplasmic reticulum membrane]
(R-HSA-190656)
GJB1 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190636)
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q2HXU8-2 CLEC12B
0.556
3
UniProt:Q3ZAQ7 VMA21
0.556
3
UniProt:P15151 PVR
1
PVR [plasma membrane]
(R-HSA-420600)
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:P20138 CD33
3
CD33 [tertiary granule membrane]
(R-HSA-6800959)
CD33 [plasma membrane]
(R-HSA-197719)
CD33 [specific granule membrane]
(R-HSA-6799615)
0.556
3
UniProt:Q86VR2 RETR3
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
UniProt:Q9BRK0 REEP2
0.556
3
UniProt:P27105 STOM
4
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [specific granule membrane]
(R-HSA-6799569)
STOM [tertiary granule membrane]
(R-HSA-6800960)
0.556
3
UniProt:O14880 MGST3
1
MGST3 [endoplasmic reticulum membrane]
(R-HSA-176053)
0.556
3
UniProt:Q96MV1 TLCD4
0.556
3
UniProt:Q9BY50 SEC11C
1
SEC11C [endoplasmic reticulum membrane]
(R-HSA-265065)
0.556
3
UniProt:Q9HA82 CERS4
1
CERS4 [endoplasmic reticulum membrane]
(R-HSA-428138)
0.556
3
UniProt:P48051 KCNJ6
1
KCNJ6 [plasma membrane]
(R-HSA-975242)
0.556
3
UniProt:Q9NY72 SCN3B
1
SCN3B [plasma membrane]
(R-HSA-197921)
0.556
3
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.556
3
UniProt:Q5SR56 MF14B
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q9UJ71 CD207
3
CD207 [early endosome membrane]
(R-HSA-1236852)
CD207 [clathrin-coated endocytic vesicle membrane]
(R-HSA-1236762)
CD207 [plasma membrane]
(R-HSA-1216519)
0.556
3
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.556
3
UniProt:Q9BQA9 CYBC1
0.556
3
UniProt:Q8TBB6 S7A14
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
UniProt:O15529 GPR42
0.556
3
UniProt:P49447 CY561
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q8NI22 MCFD2
3
MCFD2 [endoplasmic reticulum membrane]
(R-HSA-5689470)
MCFD2 [ER to Golgi transport vesicle membrane]
(R-HSA-1017216)
MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689836)
0.556
3
UniProt:Q9NPE6 SPAG4
0.556
3
UniProt:Q9NX47 MARH5
0.556
3
UniProt:Q3MIR4 CC50B
0.556
3
UniProt:Q8N4P2 IFT70B
2
TTC30B [ciliary tip]
(R-HSA-5637970)
TTC30B [cilium]
(R-HSA-5637971)
0.508
2
UniProt:A0A142I5B9 POLG
0.499
3
UniProt:D0ZIB5 STEC
0.462
2
UniProt:A0A0F6B5H5 A0A0F6B5H5
0.462
2
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