Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SEC61B [cytosol]
Stable Identifier
R-HSA-5250571
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SEC61 beta
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Homo sapiens)
SGTA binds Tail-anchored protein (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG [endoplasmic reticulum membrane] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG [endoplasmic reticulum membrane] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
SEC61B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60468 SEC61B
Gene Names
SEC61B
Chain
initiator methionine:, chain:2-96
Reference Genes
BioGPS Gene:10952 SEC61B
COSMIC (genes):SEC61B SEC61B
CTD Gene:10952 SEC61B
dbSNP Gene:10952 SEC61B
ENSEMBL:ENSG00000106803 SEC61B
ENSEMBL_homo_sapiens_GENE:ENSG00000106803.10 SEC61B
HGNC:16993 SEC61B
KEGG Gene (Homo sapiens):10952 SEC61B
Monarch:10952 SEC61B
NCBI Gene:10952 SEC61B
OMIM:609214 SEC61B
UCSC:P60468 SEC61B
Reference Transcript
RefSeq:NM_006808.2 SEC61B
Other Identifiers
10952
11716938_a_at
17087498
203133_PM_at
203133_at
3181803
3181804
3181805
3181814
3181815
3181816
3181817
3181818
3181819
32564_at
3372540
8156838
A_23_P135342
A_24_P8494
GO:0003723
GO:0005515
GO:0005783
GO:0005784
GO:0005789
GO:0005829
GO:0006616
GO:0006886
GO:0015031
GO:0016020
GO:0030163
GO:0030433
GO:0030970
GO:0031204
GO:0031205
GO:0043022
GO:0043226
GO:0044322
GO:0048408
GO:0055085
HMNXSV003035178
ILMN_1801852
L25085_at
PH_hs_0011293
PH_hs_0032087
TC09000502.hg
g5803164_3p_at
Participates
as a component of
BAG6:GET4:UBL4A:SEC61B [cytosol] (Homo sapiens)
as an input of
BAG6:GET4:UBL4A binds SEC61B (Homo sapiens)
as a member of
Tail-anchored proteins [cytosol] (Homo sapiens)
Other forms of this molecule
SEC61B [endoplasmic reticulum membrane]
SEC61B [phagocytic vesicle membrane]
Inferred To
Sec61b [cytosol]
(Mus musculus)
Sec61b [cytosol]
(Rattus norvegicus)
sbh1 [cytosol]
(Schizosaccharomyces pombe)
sec61b [cytosol]
(Danio rerio)
sec61b [cytosol]
(Dictyostelium discoideum)
sec61b [cytosol]
(Xenopus tropicalis)
Homologues of SEC61B [cytosol]
(Mus musculus)
Sec61beta [cytosol]
(Drosophila melanogaster)
sec-61.b [cytosol]
(Caenorhabditis elegans)
SBH2 [cytosol]
(Saccharomyces cerevisiae)
SEC61B [cytosol]
(Bos taurus)
SEC61B [cytosol]
(Canis familiaris)
SEC61B [cytosol]
(Gallus gallus)
SEC61B [cytosol]
(Mus musculus)
SEC61B [cytosol]
(Plasmodium falciparum)
SEC61B [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_006799.1
OpenTargets
ENSG00000106803
HPA
ENSG00000106803-SEC61B
GeneCards
P60468
Ensembl
ENSP00000223641
,
ENSG00000106803
,
ENST00000223641
PRO
P60468
Pharos - Targets
P60468
PDB
8OJ8
,
8DO2
,
8DO0
,
8DNW
,
8DNY
,
8OJ0
,
6W6L
,
8DO3
,
8DO1
,
8DNV
,
8DNX
,
8B6L
,
8DNZ
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12154 GET3
1
GET3 [cytosol]
(R-SCE-9628623)
0.683
4
UniProt:P0DTD8 NS7B
0.623
3
UniProt:P51572 BCAP31
6
BCAP31 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985503)
BCAP31 [endoplasmic reticulum membrane]
(R-HSA-9714333)
BCAP31(2-245) [endoplasmic reticulum membrane]
(R-HSA-201587)
BCAP31(165-237) [endoplasmic reticulum membrane]
(R-HSA-351909)
BCAP31(2-164) [endoplasmic reticulum membrane]
(R-HSA-351826)
BCAP31(238-246) [cytosol]
(R-HSA-351912)
0.602
7
UniProt:Q9H9S3 SEC61A2
2
SEC61A2 [endoplasmic reticulum membrane]
(R-HSA-444585)
SEC61A2 [phagocytic vesicle membrane]
(R-HSA-1236771)
0.564
2
UniProt:P43307 SSR1
1
SSR1 [endoplasmic reticulum membrane]
(R-HSA-444588)
0.564
2
UniProt:P53618 COPB1
8
COPB1 [endoplasmic reticulum membrane]
(R-HSA-6810955)
COPB1 [Golgi membrane]
(R-HSA-6808735)
COPB1 [transport vesicle]
(R-HSA-6808736)
COPB1 [cytosol]
(R-HSA-199995)
COPB1 [ficolin-1-rich granule membrane]
(R-HSA-6800972)
COPB1 [secretory granule membrane]
(R-HSA-6800914)
COPB1 [plasma membrane]
(R-HSA-6806431)
COPB1 [tertiary granule membrane]
(R-HSA-6800175)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text