Reactome | RABGGTB [plasma membrane]

RABGGTB [plasma membrane]

Stable Identifier

R-HSA-6801098

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Geranylgeranyl transferase type-2 subunit beta, GGTB, Rab geranyl-geranyltransferase subunit beta

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External Reference Information

External Reference

UniProt:P53611 RABGGTB

Gene Names

RABGGTB, GGTB

Chain

initiator methionine:1, chain:2-331

Reference Genes

BioGPS Gene:5876 RABGGTB

COSMIC (genes):RABGGTB RABGGTB

CTD Gene:5876 RABGGTB

dbSNP Gene:5876 RABGGTB

ENSEMBL:ENSG00000137955 RABGGTB

ENSEMBL:ENSG00000137955.16 RABGGTB

HGNC:9796 RABGGTB

KEGG Gene (Homo sapiens):5876 RABGGTB

Monarch:5876 RABGGTB

NCBI Gene:5876 RABGGTB

OMIM:179080 RABGGTB

Reference Transcript

RefSeq:NM_004582.3 RABGGTB

Other Identifiers

11724300_a_at

11757294_x_at

209180_PM_at

209180_at

209181_PM_s_at

209181_s_at

213704_PM_at

213704_at

2342633

2342637

2342638

2342639

2342640

2342644

2342649

2342650

2342652

2342656

2342658

2342659

2342660

2342662

37703_at

5876

781_at

7902382

A_14_P128168

A_23_P85371

A_24_P336705

A_33_P3311618

GO:0003824

GO:0004659

GO:0004663

GO:0005515

GO:0005829

GO:0005886

GO:0005968

GO:0007601

GO:0008270

GO:0008318

GO:0016740

GO:0018344

GO:0031267

GO:0036211

GO:0046872

GO:0050877

GO:0140096

HMNXSV003013751

ILMN_2163796

PH_hs_0004556

X98001_at

g1216503_3p_a_at

Participates

as a component of

RGGT [plasma membrane] (Homo sapiens)

as an input of

RABGGTA binds RABGGTB (Homo sapiens)

Other forms of this molecule

RABGGTB [cytosol]

Inferred To

RABGGTB [plasma membrane] (Bos taurus)

RABGGTB [plasma membrane] (Caenorhabditis elegans)

RABGGTB [plasma membrane] (Canis familiaris)

RABGGTB [plasma membrane] (Dictyostelium discoideum)

RABGGTB [plasma membrane] (Mus musculus)

RABGGTB [plasma membrane] (Plasmodium falciparum)

RABGGTB [plasma membrane] (Rattus norvegicus)

RABGGTB [plasma membrane] (Saccharomyces cerevisiae)

RABGGTB [plasma membrane] (Schizosaccharomyces pombe)

RabGGTb [plasma membrane] (Drosophila melanogaster)

fj12b07 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_004573.2

OpenTargets

ENSG00000137955

IntEnz

2.5.1.60

GeneCards

P53611

HPA

ENSG00000137955-RABGGTB

Ensembl

ENSG00000137955, ENST00000319942, ENSP00000317473

PRO

P53611

Pharos - Targets

P53611

HMDB Protein

HMDBP11879

PDB

6J6X, 6J7X, 6J7F, 6J74, 6O60

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P57081 WDR4	1	WDR4 [nucleoplasm] (R-HSA-6782341)	0.718	6
UniProt:Q9UBV7 B4GALT7	4	B4GALT7 A186D [Golgi membrane] (R-HSA-3621785) B4GALT7 L206P [Golgi membrane] (R-HSA-3621790) B4GALT7 R270C [Golgi membrane] (R-HSA-3621734) B4GALT7 [Golgi membrane] (R-HSA-1889950)	0.718	6
UniProt:Q92696 RABGGTA	2	RABGGTA [cytosol] (R-HSA-8870418) RABGGTA [plasma membrane] (R-HSA-6801086)	0.666	4
UniProt:P20339 RAB5A	6	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) RAB5A [cytosol] (R-HSA-2201187) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432)	0.569	3
UniProt:Q86YD3 TMM25			0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q7Z5A9 TAFA1			0.556	3
UniProt:Q96AX2 RAB37	5	RAB37 [specific granule membrane] (R-HSA-6799605) RAB37 [plasma membrane] (R-HSA-6799686) RAB37 [azurophil granule membrane] (R-HSA-6799607) RAB37 [cytosol] (R-HSA-8873678) GGC-RAB37 [cytosol] (R-HSA-8873996)	0.488	2

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