Reactome | GINS3 [nucleoplasm]

GINS3 [nucleoplasm]

Stable Identifier

R-HSA-5688046

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA replication complex GINS protein PSF3, PSF3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BRX5 GINS3

Gene Names

GINS3, PSF3

Chain

chain:1-216

Reference Genes

BioGPS Gene:64785 GINS3

COSMIC (genes):GINS3 GINS3

CTD Gene:64785 GINS3

dbSNP Gene:64785 GINS3

ENSEMBL:ENSG00000181938 GINS3

HGNC:25851 GINS3

KEGG:hsa:64785 GINS3

Monarch:64785 GINS3

NCBI Gene:64785 GINS3

OMIM:610610 GINS3

UCSC:Q9BRX5 GINS3

Reference Transcript

Other Identifiers

11739763_a_at

16819678

218719_PM_s_at

218719_s_at

3663222

3663224

3663225

3663227

3663233

3663234

3663235

3663236

3663237

3663238

3663241

3663242

3663243

3663244

3663245

3663246

3663247

3663248

3663249

3663250

3663251

3663262

45633_PM_at

45633_at

64785

7996211

A_14_P101154

A_14_P114321

A_23_P152136

A_24_P159323

GE56695

GO:0000811

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0035264

GO:0071162

GO:0090398

HMNXSV003006594

ILMN_1754272

PH_hs_0003351

TC16000502.hg

g12232448_3p_s_at

Participates

as a component of

GINS complex [nucleoplasm] (Homo sapiens)

as an input of

Formation of GINS complex (Homo sapiens)

Inferred To

psf3 [nucleoplasm] (Schizosaccharomyces pombe)

Gins3 [nucleoplasm] (Mus musculus)

Gins3 [nucleoplasm] (Rattus norvegicus)

PSF3 [nucleoplasm] (Saccharomyces cerevisiae)

GINS3 [nucleoplasm] (Bos taurus)

GINS3 [nucleoplasm] (Canis familiaris)

GINS3 [nucleoplasm] (Gallus gallus)

GINS3 [nucleoplasm] (Sus scrofa)

Psf3 [nucleoplasm] (Drosophila melanogaster)

gins3 [nucleoplasm] (Danio rerio)

gins3 [nucleoplasm] (Dictyostelium discoideum)

gins3 [nucleoplasm] (Xenopus tropicalis)

psf-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_054169707.1, XP_054169711.1, XP_054169705.1, XP_054169708.1, XP_054169709.1, NP_073607.2, NP_001119602.1, XP_054169710.1, NP_001119601.1, XP_054169706.1

OpenTargets

ENSG00000181938

ENSEMBL

ENSP00000401018, ENST00000318129, ENSG00000181938, ENSP00000318196, ENST00000426538, ENST00000328514, ENSP00000327449

HPA

ENSG00000181938-GINS3

GeneCards

GINS3

PRO

Q9BRX5

Pharos - Targets

Q9BRX5

GlyGen

Q9BRX5

PDB

8OK2, 2EHO, 8B9D, 6XTY, 6XTX, 2E9X, 7PFO, 7PLO, 2Q9Q

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.882	11
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.718	6
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.643	3
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.574	2
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:Q9UI47-2 CTNNA3			0.556	3
UniProt:O75190-2 DNAJB6			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q9UMF0 ICAM5	1	ICAM5 [plasma membrane] (R-HSA-197684)	0.556	3
UniProt:O75865-2 TRAPPC6A			0.556	3
UniProt:Q6KB66-2 KRT80			0.556	3
UniProt:Q96JP2 MY15B			0.556	3
UniProt:P14927 UQCRB	1	UQCRB [mitochondrial inner membrane] (R-HSA-164287)	0.556	3
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:P78368 CSNK1G2	2	CSNK1G2 [plasma membrane] (R-HSA-205718) CSNK1G2 [cytosol] (R-HSA-429696)	0.527	2
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.527	4
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	3
UniProt:Q9BRT9 GINS4	1	GINS4 [nucleoplasm] (R-HSA-176963)	0.527	3
UniProt:Q9BVW5 TIPIN	1	TIPIN [nucleoplasm] (R-HSA-5684983)	0.527	2

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