Reactome | PSTPIP1 [cytosol]

PSTPIP1 [cytosol]

Stable Identifier

R-HSA-879220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proline-serine-threonine phosphatase-interacting protein 1, PPIP1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        PSTPIP1 binds Pyrin (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
    - Inflammasomes (Homo sapiens)
      - The NLRP3 inflammasome (Homo sapiens)
        
        PSTPIP1 binds Pyrin (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43586 PSTPIP1

Gene Names

PSTPIP1, CD2BP1

Chain

chain:1-416

Reference Genes

BioGPS Gene:9051 PSTPIP1

COSMIC (genes):PSTPIP1 PSTPIP1

CTD Gene:9051 PSTPIP1

dbSNP Gene:9051 PSTPIP1

ENSEMBL:ENSG00000140368 PSTPIP1

HGNC:9580 PSTPIP1

KEGG:hsa:9051 PSTPIP1

Monarch:9051 PSTPIP1

NCBI Gene:9051 PSTPIP1

OMIM:606347 PSTPIP1

UCSC:O43586 PSTPIP1

Reference Transcript

Other Identifiers

11733162_a_at

11749984_s_at

11762717_at

11762739_at

16803334

211178_PM_s_at

211178_s_at

34914_at

3602771

3602772

3602773

3602774

3602779

3602781

3602782

3602785

3602786

3602787

3602788

3602789

3602791

3602792

3602793

3602794

3602797

3602798

3602799

3602800

3602801

3602802

3602803

3602804

3602805

3602806

3602807

3602810

3602811

7985099

9051

A_23_P48997

GE81340

GO:0001931

GO:0002376

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0006897

GO:0006954

GO:0007155

GO:0007165

GO:0008092

GO:0016020

GO:0016192

GO:0030027

GO:0030041

GO:0032154

GO:0042802

GO:0042995

GO:0043226

GO:0045087

GO:0048471

GO:0051015

GO:0065003

GO:0098542

HMNXSV003040421

HMNXSV003051361

ILMN_1703327

PH_hs_0007600

TC15000710.hg

g2921548_3p_a_at

Participates

as a component of

PSTPIP1 trimer [cytosol] (Homo sapiens)

Inferred To

PSTPIP1 [cytosol] (Bos taurus)

PSTPIP1 [cytosol] (Canis familiaris)

PSTPIP1 [cytosol] (Gallus gallus)

Pstpip1 [cytosol] (Mus musculus)

Pstpip1 [cytosol] (Rattus norvegicus)

pstpip1b [cytosol] (Danio rerio)

Cross References

OpenTargets

ENSG00000140368

ENSEMBL

ENSG00000140368, ENSP00000452743, ENSP00000452746, ENST00000559295, ENST00000558012

HPA

ENSG00000140368-PSTPIP1

GeneCards

PSTPIP1

PRO

O43586

Pharos - Targets

O43586

Orphanet

PSTPIP1

GlyGen

O43586

PDB

2DIL, 7AAM, 7AAL, 7AAN

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.835	9
UniProt:P06729 CD2	1	CD2 [plasma membrane] (R-HSA-197795)	0.741	6
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.718	6
UniProt:Q99952 PTPN18	2	PTPN18 [cytosol] (R-HSA-8864101) PTPN18 [nucleoplasm] (R-HSA-9008900)	0.704	5
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.697	5
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.591	6
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.556	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:P17752 TPH1	1	TPH1 [cytosol] (R-HSA-976250)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.463	2