Reactome | PSTPIP1 [cytosol]

PSTPIP1 [cytosol]

Stable Identifier

R-HSA-879220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proline-serine-threonine phosphatase-interacting protein 1, PPIP1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
    - Inflammasomes (Homo sapiens)
      - The NLRP3 inflammasome (Homo sapiens)
        
        PSTPIP1 binds Pyrin (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43586 PSTPIP1

Gene Names

PSTPIP1, CD2BP1

Chain

chain:1-416

Reference Genes

BioGPS Gene:9051 PSTPIP1

COSMIC (genes):PSTPIP1 PSTPIP1

CTD Gene:9051 PSTPIP1

dbSNP Gene:9051 PSTPIP1

ENSEMBL:ENSG00000140368 PSTPIP1

ENSEMBL_homo_sapiens_GENE:ENSG00000140368 PSTPIP1

HGNC:9580 PSTPIP1

KEGG Gene (Homo sapiens):9051 PSTPIP1

Monarch:9051 PSTPIP1

NCBI Gene:9051 PSTPIP1

OMIM:606347 PSTPIP1

UCSC:O43586 PSTPIP1

Reference Transcript

Other Identifiers

0006520068

10600

11733162_a_at

11749984_s_at

16803334

211178_s_at

2DIL

34914_at

3602772

3602773

3602774

3602781

3602782

3602786

3602787

3602789

3602791

3602792

3602797

3602798

3602801

3602803

3602805

3602807

3602810

3602811

7985099

9051

A0A0S2Z5P3

A_23_P48997

AAD00762

AAD11958

AAD11959

AAH08602

AB451310

AB451440

AF038602

AF038603

ALQ33916

B4E1Z9

BAG70124

BAG70254

BC008602

CCDS45312

CCDS81910

CH471136

EAW99213

ENSG00000140368

ENSP00000452743

ENSP00000452746

ENST00000558012

ENST00000559295

EntrezGene:9051

g2921548_3p_a_at

GE81340

GO:0001931

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0006810

GO:0006897

GO:0006950

GO:0006954

GO:0007010

GO:0007155

GO:0007165

GO:0008092

GO:0008150

GO:0016020

GO:0016192

GO:0022607

GO:0030027

GO:0030041

GO:0032154

GO:0042802

GO:0042995

GO:0043226

GO:0045087

GO:0048471

GO:0051015

GO:0065003

H0YKY3

H0YLI2

H0YLM9

H0YLW8

H0YLX8

H0YNR2

H0YNS1

HGNC:9580

HPA010600

ILMN_1703327

ILMN_1717475

IPR001060

IPR001452

IPR027267

IPR030777

IPR031160

IPR036028

J3KPG6

KU178458

LRG_172

MIM:604416

MIM:606347

NM_001321135

NM_001321136

NM_001321137

NM_003978

NP_001308064

NP_001308065

NP_001308066

NP_003969

NR_135552

PF00611

PF14604

PH_hs_0007600

PR00452

PR01887

PSTPIP1

PSTPIP1-203

PSTPIP1-207

SM00055

SM00326

TC15000710.hg

U94778

uc002bcf.3

uc010bkw.2

UPI00000703D7

UPI00000723CB

XM_006720737

XM_011522164

XM_011522165

XM_011522167

XM_011522168

XM_011522169

XP_006720800

XP_011520466

XP_011520467

XP_011520469

XP_011520470

XP_011520471

XR_931936

XR_931937

XR_931938

XR_931939

Participant Of

hasComponent

PSTPIP1 trimer [cytosol]

Inferred To

PSTPIP1 [cytosol] (Bos taurus)

PSTPIP1 [cytosol] (Canis familiaris)

PSTPIP1 [cytosol] (Danio rerio)

PSTPIP1 [cytosol] (Dictyostelium discoideum)

PSTPIP1 [cytosol] (Gallus gallus)

PSTPIP1 [cytosol] (Mus musculus)

PSTPIP1 [cytosol] (Rattus norvegicus)

PSTPIP1 [cytosol] (Sus scrofa)

Homologues of PSTPIP1 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_003969.2, NP_001308064.1, NP_001308066.1

OpenTargets

ENSG00000140368

GeneCards

O43586

PRO

O43586

Orphanet

15163

PDB

2DIL

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.766	7
UniProt:P06729 CD2	1	CD2 [plasma membrane] (R-HSA-197795)	0.741	6
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.697	5
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.696	5
UniProt:Q99952 PTPN18	2	PTPN18 [cytosol] (R-HSA-8864101) PTPN18 [nucleoplasm] (R-HSA-9008900)	0.602	4
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.591	6
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040)	0.556	3
UniProt:Q12446	6	WASL [plasma membrane] (R-SCE-203010) WASL [endocytic vesicle membrane] (R-SCE-535012) phospho-p-Y256-WASL [cytosol] (R-SCE-2197672) phospho-p-Y291-WAS [cytosol] (R-SCE-2197668) N-WASP [cytosol] (R-SCE-201873) WAS [cytosol] (R-SCE-201879)	0.556	3
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.488	2
UniProt:Q08426 EHHADH	2	EHHADH [cytosol] (R-HSA-9033147) EHHADH [peroxisomal matrix] (R-HSA-400155)	0.488	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.488	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.488	2
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.463	2