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PSTPIP1 [cytosol]
Stable Identifier
R-HSA-879220
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proline-serine-threonine phosphatase-interacting protein 1, PPIP1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
PSTPIP1 binds Pyrin (Homo sapiens)
PSTPIP1 trimer [cytosol] (Homo sapiens)
PSTPIP1 [cytosol] (Homo sapiens)
PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
PSTPIP1 trimer [cytosol] (Homo sapiens)
PSTPIP1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
PSTPIP1 binds Pyrin (Homo sapiens)
PSTPIP1 trimer [cytosol] (Homo sapiens)
PSTPIP1 [cytosol] (Homo sapiens)
PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
PSTPIP1 trimer [cytosol] (Homo sapiens)
PSTPIP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43586 PSTPIP1
Gene Names
PSTPIP1, CD2BP1
Chain
chain:1-416
Reference Genes
BioGPS Gene:9051 PSTPIP1
COSMIC (genes):PSTPIP1 PSTPIP1
CTD Gene:9051 PSTPIP1
dbSNP Gene:9051 PSTPIP1
ENSEMBL:ENSG00000140368 PSTPIP1
HGNC:9580 PSTPIP1
KEGG Gene (Homo sapiens):9051 PSTPIP1
Monarch:9051 PSTPIP1
NCBI Gene:9051 PSTPIP1
OMIM:606347 PSTPIP1
UCSC:O43586 PSTPIP1
Reference Transcript
RefSeq:NM_001321135.1 PSTPIP1
RefSeq:NM_001321137.1 PSTPIP1
RefSeq:NM_003978.4 PSTPIP1
Other Identifiers
0006520068
10600
11733162_a_at
11749984_s_at
16803334
211178_s_at
2DIL
34914_at
3602772
3602773
3602774
3602781
3602782
3602786
3602787
3602789
3602791
3602792
3602797
3602798
3602801
3602803
3602805
3602807
3602810
3602811
7985099
9051
A0A0S2Z5P3
A_23_P48997
AAD00762
AAD11958
AAD11959
AAH08602
AB451310
AB451440
AF038602
AF038603
ALQ33916
B4E1Z9
BAG70124
BAG70254
BC008602
CCDS45312
CCDS81910
CH471136
EAW99213
ENSG00000140368
ENSP00000452743
ENSP00000452746
ENST00000558012
ENST00000558012.5
ENST00000559295
ENST00000559295.5
EntrezGene:9051
EntrezGene:PSTPIP1
g2921548_3p_a_at
GE81340
GO:0001931
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006810
GO:0006897
GO:0006950
GO:0006954
GO:0007155
GO:0007165
GO:0008092
GO:0008150
GO:0016020
GO:0016192
GO:0030027
GO:0032154
GO:0042802
GO:0042995
GO:0043226
GO:0045087
GO:0048471
H0YKY3
H0YLI2
H0YLM9
H0YLW8
H0YLX8
H0YNR2
H0YNS1
HGNC:9580
HPA010600
ILMN_1703327
ILMN_1717475
IPR001060
IPR001452
IPR027267
IPR030777
IPR031160
IPR036028
J3KPG6
KU178458
LRG_172
MIM:604416
MIM:606347
NM_001321135
NM_001321136
NM_001321137
NM_003978
NP_001308064
NP_001308065
NP_001308066
NP_003969
NR_135552
PF00611
PF14604
PH_hs_0007600
PR00452
PR01887
PSTPIP1
PSTPIP1-203
PSTPIP1-207
SM00055
SM00326
TC15000710.hg
U94778
UPI00000703D7
UPI00000723CB
XM_006720737
XM_011522164
XM_011522165
XM_011522167
XM_011522168
XM_011522169
XP_006720800
XP_011520466
XP_011520467
XP_011520469
XP_011520470
XP_011520471
XR_931939
Participant Of
hasComponent
PSTPIP1 trimer [cytosol]
Inferred To
PSTPIP1 [cytosol] (Bos taurus)
PSTPIP1 [cytosol] (Canis familiaris)
PSTPIP1 [cytosol] (Dictyostelium discoideum)
PSTPIP1 [cytosol] (Gallus gallus)
PSTPIP1 [cytosol] (Sus scrofa)
pstpip1a [cytosol] (Danio rerio)
Homologues of PSTPIP1 [cytosol] (Dictyostelium discoideum)
Pstpip1 [cytosol] (Mus musculus)
Pstpip1 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_001308064.1
,
NP_003969.2
,
NP_001308066.1
OpenTargets
ENSG00000140368
GeneCards
O43586
HPA
ENSG00000140368-PSTPIP1
Ensembl
ENST00000559295
,
ENST00000558012
,
ENSP00000452743
,
ENSG00000140368
,
ENSP00000452746
PRO
O43586
Orphanet
15163
PDB
2DIL
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.783
8
UniProt:P06729 CD2
1
CD2 [plasma membrane]
(R-HSA-197795)
0.741
6
UniProt:O75386 TULP3
1
TULP3 [cilium]
(R-HSA-5610445)
0.718
6
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.697
5
UniProt:Q99952 PTPN18
2
PTPN18 [cytosol]
(R-HSA-8864101)
PTPN18 [nucleoplasm]
(R-HSA-9008900)
0.602
4
UniProt:Q9Y2R2 PTPN22
1
PTPN22 [cytosol]
(R-HSA-8852205)
0.591
6
UniProt:O43684 BUB3
1
BUB3 [cytosol]
(R-HSA-141416)
0.556
3
UniProt:O15169 AXIN1
11
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
AXIN1 [cytosol]
(R-HSA-195249)
p-T519,S524,S531-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
0.556
3
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.556
3
UniProt:Q15287 RNPS1
2
RNPS1 [cytosol]
(R-HSA-159256)
RNPS1 [nucleoplasm]
(R-HSA-156778)
0.556
3
UniProt:P17752 TPH1
1
TPH1 [cytosol]
(R-HSA-976250)
0.556
3
UniProt:Q12446
6
LAS17 [plasma membrane]
(R-SCE-203010)
LAS17 [endocytic vesicle membrane]
(R-SCE-535012)
phospho-LAS17 [cytosol]
(R-SCE-2197672)
phospho-LAS17 [cytosol]
(R-SCE-2197668)
LAS17 [cytosol]
(R-SCE-201879)
LAS17 [cytosol]
(R-SCE-201873)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
0.556
3
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.556
3
UniProt:Q08426 EHHADH
2
EHHADH [cytosol]
(R-HSA-9033147)
EHHADH [peroxisomal matrix]
(R-HSA-400155)
0.556
3
UniProt:P42768 WAS
2
p-Y291-WAS [cytosol]
(R-HSA-2197668)
WAS [cytosol]
(R-HSA-201879)
0.463
2
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