Reactome | PSTPIP1 [cytosol]

PSTPIP1 [cytosol]

Stable Identifier

R-HSA-879220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proline-serine-threonine phosphatase-interacting protein 1, PPIP1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        PSTPIP1 binds Pyrin (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
    - Inflammasomes (Homo sapiens)
      - The NLRP3 inflammasome (Homo sapiens)
        
        PSTPIP1 binds Pyrin (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 trimer [cytosol] (Homo sapiens)
        
        PSTPIP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43586 PSTPIP1

Gene Names

PSTPIP1, CD2BP1

Chain

chain:1-416

Reference Genes

BioGPS Gene:9051 PSTPIP1

COSMIC (genes):PSTPIP1 PSTPIP1

CTD Gene:9051 PSTPIP1

dbSNP Gene:9051 PSTPIP1

ENSEMBL:ENSG00000140368.14 PSTPIP1

HGNC:9580 PSTPIP1

KEGG Gene (Homo sapiens):9051 PSTPIP1

Monarch:9051 PSTPIP1

NCBI Gene:9051 PSTPIP1

OMIM:606347 PSTPIP1

UCSC:O43586 PSTPIP1

Reference Transcript

Other Identifiers

11733162_a_at

11749984_s_at

16803334

211178_PM_s_at

211178_s_at

34914_at

3602772

3602773

3602774

3602781

3602782

3602786

3602787

3602789

3602791

3602792

3602797

3602798

3602801

3602803

3602805

3602807

3602810

3602811

7985099

9051

A_23_P48997

GE81340

GO:0001931

GO:0002376

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0006897

GO:0006954

GO:0007010

GO:0007155

GO:0007165

GO:0008092

GO:0016020

GO:0016192

GO:0023052

GO:0030027

GO:0030041

GO:0032154

GO:0042802

GO:0042995

GO:0043226

GO:0045087

GO:0048471

GO:0051015

GO:0065003

GO:0098542

HMNXSV003040421

HMNXSV003051361

ILMN_1703327

PH_hs_0007600

TC15000710.hg

g2921548_3p_a_at

Participates

as a component of

PSTPIP1 trimer [cytosol] (Homo sapiens)

Inferred To

pstpip1 [cytosol] (Xenopus tropicalis)

PSTPIP1 [cytosol] (Bos taurus)

PSTPIP1 [cytosol] (Canis familiaris)

PSTPIP1 [cytosol] (Gallus gallus)

Pstpip1 [cytosol] (Mus musculus)

Pstpip1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001308066.1, NP_003969.2, NP_001308064.1

OpenTargets

ENSG00000140368

HPA

ENSG00000140368-PSTPIP1

GeneCards

O43586

Ensembl

ENST00000559295, ENSP00000452746, ENSG00000140368, ENST00000558012, ENSP00000452743

PRO

O43586

Pharos - Targets

O43586

Orphanet

15163

PDB

7AAN, 7AAL, 2DIL, 7AAM

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.783	8
UniProt:P06729 CD2	1	CD2 [plasma membrane] (R-HSA-197795)	0.741	6
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.718	6
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.697	5
UniProt:Q99952 PTPN18	2	PTPN18 [nucleoplasm] (R-HSA-9008900) PTPN18 [cytosol] (R-HSA-8864101)	0.602	4
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.591	6
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.556	3
UniProt:P17752 TPH1	1	TPH1 [cytosol] (R-HSA-976250)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.556	3
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.463	2

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