Reactome | NGFRAP1 [cytosol]

NGFRAP1 [cytosol]

Stable Identifier

R-HSA-194333

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NADE, p75NTR-associated cell death executor, NADE_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q00994 BEX3

Gene Names

BEX3, DXS6984E, NADE, NGFRAP1

Chain

chain:1-111

Reference Genes

BioGPS Gene:27018 BEX3

COSMIC (genes):BEX3 BEX3

CTD Gene:27018 BEX3

dbSNP Gene:27018 BEX3

ENSEMBL:ENSG00000166681 BEX3

HGNC:13388 BEX3

KEGG Gene (Homo sapiens):27018 BEX3

Monarch:27018 BEX3

NCBI Gene:27018 BEX3

OMIM:300361 BEX3

UCSC:Q00994 BEX3

Reference Transcript

Other Identifiers

0003780358

11719372_s_at

17105712

217963_s_at

27018

3985541

3985542

3985543

3985544

3985545

3985546

3985547

3985548

3985549

3985550

3985554

3985555

3985556

3985557

3985558

3985559

4016316

45236_at

8169028

A_23_P45524

GE567535

GO:0003674

GO:0005102

GO:0005163

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006915

GO:0006919

GO:0007165

GO:0007275

GO:0008150

GO:0008219

GO:0008656

GO:0030234

GO:0042802

GO:0043154

GO:0043167

GO:0043226

GO:0043281

GO:0046872

GO:0048856

HMNXSV003011142

ILMN_1729208

ILMN_2370091

TC0X000496.hg

g7657043_3p_s_at

Participates

as a component of

NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)

as an input of

p75NTR binds to NADE (Homo sapiens)

Inferred To

Bex3 [cytosol] (Mus musculus)

Bex3 [cytosol] (Rattus norvegicus)

BEX3 [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_055195.1, NP_996798.1, NP_996800.1

OpenTargets

ENSG00000166681

HPA

ENSG00000166681-BEX3

GeneCards

Q00994

Ensembl

ENST00000372645, ENSP00000361718, ENSP00000361717, ENST00000372635, ENSP00000354843, ENSG00000166681, ENSP00000361728, ENST00000361298, ENST00000372634

PRO

Q00994

PDB

1SA6

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N6Y0 USBP1			0.718	6
UniProt:A1L4K1 FSD2			0.718	6
UniProt:Q7Z6G3-2 NECAB2			0.718	6
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.666	4
UniProt:Q8IYX3 CC116			0.666	4
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:Q99598 TSNAX	1	TSNAX [cytosol] (R-HSA-5216130)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q9Y6C2 EMILIN1	1	EMILIN1 [extracellular region] (R-HSA-2161355)	0.556	3
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:Q8WYA6 CTNNBL1	1	CTNNBL1 [nucleoplasm] (R-HSA-5420895)	0.556	3
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.556	3
UniProt:Q8WYH8 ING5	1	ING5 [nucleoplasm] (R-HSA-3215169)	0.556	3
UniProt:Q13515 BFSP2			0.556	3
UniProt:Q9UNL4 ING4	1	ING4 [nucleoplasm] (R-HSA-3215153)	0.556	3
UniProt:Q9Y6C2-2 EMILIN1			0.556	6
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:P59942 MCCD1			0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P26378-2 P263782			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q0D2H9 GOG8D			0.556	3
UniProt:P01112 HRAS	23	HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912)	0.556	3
UniProt:Q8WXG8 S100Z			0.556	5
UniProt:Q08AF8 GOG8F			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.543	5

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