Reactome | NGFRAP1 [cytosol]

NGFRAP1 [cytosol]

Stable Identifier

R-HSA-194333

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NADE, p75NTR-associated cell death executor, NADE_HUMAN

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External Reference Information

External Reference

UniProt:Q00994 BEX3

Gene Names

BEX3, DXS6984E, NADE, NGFRAP1

Chain

chain:1-111

Reference Genes

BioGPS Gene:27018 BEX3

CTD Gene:27018 BEX3

dbSNP Gene:27018 BEX3

ENSEMBL:ENSG00000166681 BEX3

HGNC:13388 BEX3

KEGG Gene (Homo sapiens):27018 BEX3

Monarch:27018 BEX3

NCBI Gene:27018 BEX3

OMIM:300361 BEX3

UCSC:Q00994 BEX3

Reference Transcript

Other Identifiers

0003780358

11719372_s_at

17105712

18886

1SA6

217963_s_at

27018

3985541

3985542

3985543

3985544

3985545

3985546

3985547

3985548

3985549

3985550

3985554

3985555

3985556

3985557

3985558

3985559

4016316

45236_at

8169028

A_23_P45524

AAA63232

AAF75129

AAH03190

AAX40680

AF187064

AK315371

AL606763

AY833562

BAG37764

BC003190

BEX3

BEX3-201

BEX3-202

BEX3-203

BEX3-204

CCDS14508

CCDS14509

CH471190

EAW54710

EAW54712

EL953547

ENSG00000166681

ENSP00000354843

ENSP00000361717

ENSP00000361718

ENSP00000361728

ENST00000361298

ENST00000361298.8

ENST00000372634

ENST00000372634.1

ENST00000372635

ENST00000372635.1

ENST00000372645

ENST00000372645.3

EntrezGene:27018

EntrezGene:BEX3

g7657043_3p_s_at

GE567535

GO:0003674

GO:0005123

GO:0005163

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0006915

GO:0006919

GO:0007165

GO:0007275

GO:0008150

GO:0008219

GO:0008625

GO:0008656

GO:0030234

GO:0042802

GO:0043154

GO:0043167

GO:0043226

GO:0043281

GO:0046872

GO:0048856

HGNC:13388

HPA018886

ILMN_1729208

ILMN_2370091

IPR007623

IPR021156

M38188

MIM:300361

NM_001282674

NM_014380

NM_206915

NM_206917

NP_001269603

NP_055195

NP_996798

NP_996800

PF04538

TC0X000496.hg

UPI000012FCCA

UPI00002121CF

Participant Of

input

p75NTR binds to NADE

hasComponent

NGF:p75NTR:NADE [plasma membrane]

Inferred To

Bex3 [cytosol] (Mus musculus)

Bex3 [cytosol] (Rattus norvegicus)

BEX3 [cytosol] (Bos taurus)

BEX3 [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_055195.1, NP_996800.1, NP_996798.1

OpenTargets

ENSG00000166681

GeneCards

Q00994

HPA

ENSG00000166681-BEX3

Ensembl

ENSP00000361718, ENSP00000361728, ENST00000372634, ENSP00000361717, ENST00000372645, ENSP00000354843, ENSG00000166681, ENST00000361298, ENST00000372635

PRO

Q00994

PDB

1SA6

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N6Y0 USBP1			0.718	6
UniProt:A1L4K1 FSD2			0.718	6
UniProt:Q7Z6G3-2 NECAB2			0.718	6
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.666	4
UniProt:Q8IYX3 CC116			0.666	4
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.556	3
UniProt:Q99598 TSNAX	1	TSNAX [cytosol] (R-HSA-5216130)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q9Y6C2 EMILIN1	1	EMILIN1 [extracellular region] (R-HSA-2161355)	0.556	3
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:Q8WYA6 CTNNBL1	1	CTNNBL1 [nucleoplasm] (R-HSA-5420895)	0.556	3
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.556	3
UniProt:Q8WYH8 ING5	1	ING5 [nucleoplasm] (R-HSA-3215169)	0.556	3
UniProt:Q13515 BFSP2			0.556	3
UniProt:Q9UNL4 ING4	1	ING4 [nucleoplasm] (R-HSA-3215153)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q0D2H9 GOG8D			0.556	3
UniProt:Q8WXG8 S100Z			0.556	5
UniProt:Q08AF8 GOG8F			0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:P59942 MCCD1			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q9Y6C2-2 EMILIN1			0.556	6
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.543	5