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RELB [cytosol]
Stable Identifier
R-HSA-5607652
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Transcription factor RelB, RELB_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p52:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p52:RELB translocates from cytosol to nucleus (Homo sapiens)
p52:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p52:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p100:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
p52:RELB translocates from cytosol to nucleus (Homo sapiens)
p52:RELB [cytosol] (Homo sapiens)
RELB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01201 RELB
Gene Names
RELB
Chain
chain:1-579
Reference Genes
BioGPS Gene:5971 RELB
COSMIC (genes):RELB RELB
CTD Gene:5971 RELB
dbSNP Gene:5971 RELB
ENSEMBL:ENSG00000104856.15 RELB
HGNC:9956 RELB
KEGG Gene (Homo sapiens):5971 RELB
Monarch:5971 RELB
NCBI Gene:5971 RELB
OMIM:604758 RELB
UCSC:Q01201 RELB
Reference Transcript
RefSeq:NM_006509.3 RELB
Other Identifiers
11722141_at
16863168
205205_PM_at
205205_at
3835967
3835968
3835969
3835971
3835972
3835973
3835974
3835975
3835977
3835978
3835980
3835981
3835982
570_at
5971
8029580
A_23_P55706
GE58104
GO:0000785
GO:0000978
GO:0000981
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0007249
GO:0010605
GO:0017053
GO:0019882
GO:0019901
GO:0023052
GO:0030098
GO:0030154
GO:0032688
GO:0032922
GO:0032991
GO:0034097
GO:0038061
GO:0042088
GO:0042802
GO:0043011
GO:0043226
GO:0045063
GO:0045087
GO:0045202
GO:0045892
GO:0045944
GO:0048511
GO:0048856
GO:0071159
GO:0071470
GO:0098542
GO:0140110
HMNXSV003047976
ILMN_1811258
M83221_at
PH_hs_0029714
PH_hs_0032608
TC19000638.hg
g5730006_3p_at
g5730006_3p_x_at
Participates
as a component of
p100:RELB [cytosol] (Homo sapiens)
p52:RELB [cytosol] (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
p-7S-p100:RELB [cytosol] (Homo sapiens)
Other forms of this molecule
RELB [nucleoplasm]
Inferred To
Ghost homologue of RELB [cytosol]
(Gallus gallus)
Rel [cytosol]
(Drosophila melanogaster)
Relb [cytosol]
(Mus musculus)
Relb [cytosol]
(Rattus norvegicus)
RELB [cytosol]
(Bos taurus)
RELB [cytosol]
(Canis familiaris)
RELB [cytosol]
(Danio rerio)
RELB [cytosol]
(Sus scrofa)
relb [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006500.2
OpenTargets
ENSG00000104856
HPA
ENSG00000104856-RELB
GeneCards
Q01201
Ensembl
ENST00000221452
,
ENSG00000104856
,
ENSP00000221452
PRO
Q01201
Pharos - Targets
Q01201
Orphanet
28532
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.772
5
UniProt:Q04206-2 RELA
0.564
2
UniProt:P25963 NFKBIA
11
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
(R-HSA-5607659)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-9711050)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.564
2
UniProt:O00221 NFKBIE
3
p-S157,S161-Ub-NFKBIE [cytosol]
(R-HSA-1168563)
p-S157,S161-NFKBIE [cytosol]
(R-HSA-1168561)
NFKBIE [cytosol]
(R-HSA-1168580)
0.564
2
UniProt:Q00653 NFKB2
6
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
p-7S-p100 [cytosol]
(R-HSA-5607629)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
0.564
3
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.544
4
UniProt:Q8N668 COMMD1
2
COMMD1 [nucleoplasm]
(R-HSA-8955094)
COMMD1 [cytosol]
(R-HSA-8955110)
0.499
2
UniProt:Q04206 RELA
6
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.483
2
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