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PACSIN3 [cytosol]
Stable Identifier
R-HSA-8868270
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein kinase C and casein kinase substrate in neurons protein 3, PACN3_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PACSIN dimers [cytosol] (Homo sapiens)
PACSIN3 dimer [cytosol] (Homo sapiens)
PACSIN3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKS6 PACSIN3
Gene Names
PACSIN3
Chain
chain:1-424
Reference Genes
BioGPS Gene:29763 PACSIN3
COSMIC (genes):PACSIN3 PACSIN3
CTD Gene:29763 PACSIN3
dbSNP Gene:29763 PACSIN3
ENSEMBL:ENSG00000165912 PACSIN3
ENSEMBL_homo_sapiens_GENE:ENSG00000165912.16 PACSIN3
HGNC:8572 PACSIN3
KEGG Gene (Homo sapiens):29763 PACSIN3
Monarch:29763 PACSIN3
NCBI Gene:29763 PACSIN3
OMIM:606513 PACSIN3
UCSC:Q9UKS6 PACSIN3
Reference Transcript
RefSeq:NM_001184975.1 PACSIN3
RefSeq:NM_001184974.1 PACSIN3
RefSeq:NM_016223.4 PACSIN3
Other Identifiers
11719970_a_at
11719971_at
11748826_a_at
16737925
218744_PM_s_at
218744_s_at
235734_PM_at
235734_at
29763
3371965
3371966
3371967
3371968
3371969
3371970
3371972
3371973
3371974
3371975
3371976
3371977
3371980
3371983
3371984
7947801
84751_at
A_24_P381136
GE62243
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006897
GO:0007010
GO:0008092
GO:0008289
GO:0016020
GO:0016192
GO:0019855
GO:0030100
GO:0030163
GO:0031410
GO:0042802
GO:0043226
GO:0045806
GO:0051044
GO:0051926
GO:0061024
GO:0070062
GO:0097320
GO:0098772
HMNXSV003038732
Hs.173281.0.A1_3p_at
ILMN_1682957
PH_hs_0016456
TC11001731.hg
g7705894_3p_s_at
Participates
as a component of
PACSIN3 dimer [cytosol] (Homo sapiens)
Inferred To
cdc15 [cytosol]
(Schizosaccharomyces pombe)
sdpn-1 [cytosol]
(Caenorhabditis elegans)
Pacsin3 [cytosol]
(Mus musculus)
Pacsin3 [cytosol]
(Rattus norvegicus)
mgp1 [cytosol]
(Dictyostelium discoideum)
rga9 [cytosol]
(Schizosaccharomyces pombe)
Synd [cytosol]
(Drosophila melanogaster)
syp1 [cytosol]
(Schizosaccharomyces pombe)
PACSIN3 [cytosol]
(Bos taurus)
PACSIN3 [cytosol]
(Canis familiaris)
PACSIN3 [cytosol]
(Dictyostelium discoideum)
PACSIN3 [cytosol]
(Gallus gallus)
PACSIN3 [cytosol]
(Sus scrofa)
rga8 [cytosol]
(Schizosaccharomyces pombe)
Homologues of PACSIN3 [cytosol]
(Dictyostelium discoideum)
Homologues of PACSIN3 [cytosol]
(Schizosaccharomyces pombe)
imp2 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001171904.1
,
NP_001171903.1
,
NP_057307.2
OpenTargets
ENSG00000165912
HPA
ENSG00000165912-PACSIN3
GeneCards
Q9UKS6
Ensembl
ENSG00000165912
,
ENST00000298838
,
ENSP00000298838
,
ENSP00000440945
,
ENST00000539589
PRO
Q9UKS6
Pharos - Targets
Q9UKS6
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.591
4
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.556
3
UniProt:O43597 SPRY2
8
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
0.556
3
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
0.544
3
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.524
2
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