Reactome | SMARCD1 binds SMARCC1 homodimer

SMARCD1 binds SMARCC1 homodimer

Stable Identifier

R-HSA-9932450

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The initiating step in the assembly of a SWI/SNF complex is the formation trimer consisting of two SMARCC and a single SMARCD protein (Mashtalir et al, 2018). Based on studies in mouse, the canonical BAF complexes found in embryonic stem cells form around a core of a homodimer of SMARCC1 (BAF155) and SMARCD1 (BAF60A) to the exclusion of SMARCC2 (BAF170) and SMARCD2 or SMARCD3 (BAF 60B and BAF60C, respectively) (Ho et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
19279220	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency Ho, L, Ronan, JL, Wu, J, Staahl, BT, Chen, L, Kuo, A, Lessard, J, Nesvizhskii, AI, Ranish, J, Crabtree, GR	Proc Natl Acad Sci U S A	2009
30343899	Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes Mashtalir, N, D'Avino, AR, Michel, BC, Luo, J, Pan, J, Otto, JE, Zullow, HJ, McKenzie, ZM, Kubiak, RL, St Pierre, R, Valencia, AM, Poynter, SJ, Cassel, SH, Ranish, JA, Kadoch, C	Cell	2018