Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SMARCA2 [nucleoplasm]
Stable Identifier
R-HSA-389256
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hBrm
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M and the SWI/SNF complex bind the TYR promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYRP1 gene expression (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (Homo sapiens)
DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds the SWI/SNF complex (Homo sapiens)
RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
SMARCA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51531 SMARCA2
Gene Names
SMARCA2, BAF190B, BRM, SNF2A, SNF2L2
Chain
chain:1-1590
Reference Genes
BioGPS Gene:6595 SMARCA2
COSMIC (genes):SMARCA2 SMARCA2
CTD Gene:6595 SMARCA2
dbSNP Gene:6595 SMARCA2
ENSEMBL:ENSG00000080503 SMARCA2
ENSEMBL_homo_sapiens_GENE:ENSG00000080503.25 SMARCA2
HGNC:11098 SMARCA2
KEGG Gene (Homo sapiens):6595 SMARCA2
Monarch:6595 SMARCA2
NCBI Gene:6595 SMARCA2
OMIM:600014 SMARCA2
UCSC:P51531 SMARCA2
Reference Transcript
RefSeq:NM_001289396.1 SMARCA2
RefSeq:NM_001289397.1 SMARCA2
RefSeq:NM_003070.4 SMARCA2
RefSeq:NM_139045.3 SMARCA2
Other Identifiers
11739996_a_at
11739997_s_at
11739998_x_at
11743340_a_at
11743341_a_at
11747749_a_at
11753198_a_at
11753199_x_at
17083144
206542_PM_s_at
206542_s_at
206544_PM_x_at
206544_x_at
212257_PM_s_at
212257_s_at
3159956
3159957
3159958
3159959
3159964
3159969
3159974
3159975
3159976
3159979
3159981
3159982
3159983
3159986
3159987
3159988
3159989
3159993
3159995
3159997
3160000
3160001
3160003
3160005
3160006
3160007
3160008
3160009
3160010
3160013
3160014
3160016
3160017
3160018
3160021
3160023
3160032
3160033
3160037
3160042
3160043
3160044
3160045
3160062
3160065
3160073
3160074
3160075
3160078
3160079
3160082
3160085
3160086
3160087
40961_at
40962_s_at
6595
8154059
A_14_P112573
A_23_P252764
A_23_P60354
D26155_s_at
GE81231
GO:0000122
GO:0000166
GO:0000278
GO:0000785
GO:0000976
GO:0002376
GO:0003677
GO:0003682
GO:0003713
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005856
GO:0006281
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0007059
GO:0007155
GO:0007286
GO:0007399
GO:0008094
GO:0008284
GO:0008285
GO:0016514
GO:0016787
GO:0022414
GO:0030071
GO:0030154
GO:0030308
GO:0035060
GO:0042393
GO:0043226
GO:0043231
GO:0045111
GO:0045582
GO:0045596
GO:0045597
GO:0045663
GO:0045892
GO:0045893
GO:0045944
GO:0048856
GO:0070316
GO:0070603
GO:0071564
GO:0071565
GO:0140092
GO:0140097
GO:0140110
GO:0140288
GO:0140657
GO:0140658
GO:1902459
GO:2000045
GO:2000781
GO:2000819
HMNXSV003011102
Hs.198296.2.S1_3p_a_at
ILMN_1672419
ILMN_1791702
PH_hs_0033106
TC09000013.hg
TC09001792.hg
X72889_at
g4507068_3p_a_at
Participates
as a member of
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
Inferred To
Smarca2 [nucleoplasm]
(Rattus norvegicus)
smarca2 [nucleoplasm]
(Xenopus tropicalis)
Homologues of SMARCA2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of SMARCA2 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of SMARCA2 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of SMARCA2 [nucleoplasm]
(Schizosaccharomyces pombe)
pqn-15 [nucleoplasm]
(Caenorhabditis elegans)
SMARCA2 [nucleoplasm]
(Bos taurus)
SMARCA2 [nucleoplasm]
(Caenorhabditis elegans)
SMARCA2 [nucleoplasm]
(Canis familiaris)
SMARCA2 [nucleoplasm]
(Dictyostelium discoideum)
SMARCA2 [nucleoplasm]
(Drosophila melanogaster)
SMARCA2 [nucleoplasm]
(Gallus gallus)
SMARCA2 [nucleoplasm]
(Mus musculus)
SMARCA2 [nucleoplasm]
(Saccharomyces cerevisiae)
SMARCA2 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001276326.1
,
NP_003061.3
,
NP_620614.2
,
NP_001276325.1
Guide to Pharmacology - Targets
2739
OpenTargets
ENSG00000080503
GeneCards
P51531
HPA
ENSG00000080503-SMARCA2
ZINC target
P51531
Ensembl
ENST00000349721
,
ENST00000357248
,
ENST00000382203
,
ENSP00000371629
,
ENSP00000371638
,
ENSG00000080503
,
ENSP00000349788
,
ENST00000382194
,
ENSP00000265773
PRO
P51531
Pharos - Targets
P51531
Orphanet
20810
PDB
7Z6L
,
6HAZ
,
7S4E
,
7Z76
,
8QJT
,
8G1P
,
6HAX
,
2DAT
,
7Z77
,
5DKC
,
6HAY
,
6EG2
,
4QY4
,
7Z78
,
6EG3
,
5DKH
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.592
2
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.536
2
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.524
2
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.508
2
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text