Reactome | NELFA [nucleoplasm]

NELFA [nucleoplasm]

Stable Identifier

R-HSA-112426

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NELF-A protein, Negative elongation factor A, NELF-A, Wolf-Hirshhorn syndrome candidate 2 protein, P/OKCL.15

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H3P2 NELFA

Gene Names

NELFA, WHSC2, P/OKcl.15

Chain

chain:1-528

Reference Genes

BioGPS Gene:7469 NELFA

COSMIC (genes):NELFA NELFA

CTD Gene:7469 NELFA

dbSNP Gene:7469 NELFA

ENSEMBL:ENSG00000185049 NELFA

ENSEMBL:ENSG00000185049.16 NELFA

HGNC:12768 NELFA

KEGG Gene (Homo sapiens):7469 NELFA

Monarch:7469 NELFA

NCBI Gene:7469 NELFA

OMIM:606026 NELFA

UCSC:Q9H3P2 NELFA

Reference Transcript

RefSeq:NM_005663.4 NELFA

Other Identifiers

11743752_a_at

203112_PM_s_at

203112_s_at

2757542

2757543

2757544

2757546

2757548

2757550

2757551

2757552

2757553

2757555

2757556

2757560

2757561

2757581

34225_PM_at

34225_at

7469

8098942

A_24_P83183

GE55745

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0016604

GO:0032021

GO:0034244

GO:0036211

GO:0043226

GO:0045944

GO:0051571

GO:0060090

HMNXSV003040455

ILMN_1815083

PH_hs_0001892

g5032226_3p_s_at

Participates

as a component of

as an input of

Formation of NELF complex (Homo sapiens)

Inferred To

nelfa [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of NELFA [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of NELFA [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of NELFA [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of NELFA [nucleoplasm] (Schizosaccharomyces pombe)

Nelf-A [nucleoplasm] (Drosophila melanogaster)

Nelfa [nucleoplasm] (Mus musculus)

Nelfa [nucleoplasm] (Rattus norvegicus)

NELFA [nucleoplasm] (Bos taurus)

NELFA [nucleoplasm] (Canis familiaris)

NELFA [nucleoplasm] (Danio rerio)

NELFA [nucleoplasm] (Gallus gallus)

NELFA [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005654.3

OpenTargets

ENSG00000185049

HPA

ENSG00000185049-NELFA

GeneCards

Q9H3P2

Ensembl

ENST00000382882, ENSG00000185049, ENSP00000372335

PRO

Q9H3P2

Pharos - Targets

Q9H3P2

Orphanet

15723

PDB

7YCX, 6GML, 5L3X, 7PKS

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IXH7 NELFCD	1	NELFCD [nucleoplasm] (R-HSA-112428)	0.831	12
UniProt:P18615 NELFE	2	p-NELFE [nucleoplasm] (R-HSA-170698) NELFE [nucleoplasm] (R-HSA-62907)	0.758	7
UniProt:Q8IXH7-4 NELFCD			0.737	5
UniProt:Q8WX92 NELFB	3	NELFB [nucleoplasm] (R-HSA-112427) NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526)	0.69	4
UniProt:Q00526 CDK3			0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
IntAct:EBI-22412087 CCSB ORF ID			0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
IntAct:EBI-10220116 163154			0.556	3
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.556	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100)	0.527	2
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.527	2
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.527	2
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.508	2
UniProt:Q8IXH7-1 NELFCD			0.462	2

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