Reactome | GPS2 [nucleoplasm]

GPS2 [nucleoplasm]

Stable Identifier

R-HSA-351642

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

GPS2_HUMAN, G protein pathway suppressor 2, AMF1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by MECP2 (Homo sapiens)
      - Regulation of MECP2 expression and activity (Homo sapiens)
        
        MECP2 binds the NCoR/SMRT complex (Homo sapiens)
        
        MECP2:NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCOR1 complex [nucleoplasm] (Homo sapiens)
        
        NCOR1:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)
        
        NCOR2 complex [nucleoplasm] (Homo sapiens)
        
        NCOR2:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)
        
        NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCOR1 complex [nucleoplasm] (Homo sapiens)
        
        NCOR1:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)
        
        NCOR2 complex [nucleoplasm] (Homo sapiens)
        
        NCOR2:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ABCA1 (Homo sapiens)
        
        ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13227 GPS2

Gene Names

GPS2

Chain

chain:1-327

Reference Genes

BioGPS Gene:2874 GPS2

COSMIC (genes):GPS2 GPS2

CTD Gene:2874 GPS2

dbSNP Gene:2874 GPS2

ENSEMBL:ENSG00000132522 GPS2

HGNC:4550 GPS2

KEGG Gene (Homo sapiens):2874 GPS2

Monarch:2874 GPS2

NCBI Gene:2874 GPS2

OMIM:601935 GPS2

UCSC:Q13227 GPS2

Reference Transcript

RefSeq:NM_004489.4 GPS2

Other Identifiers

11747851_a_at

16840620

209350_3p_s_at

209350_s_at

2874

2L5G

3196764

3196765

3196771

35653_at

3743612

3743613

3743615

3743616

3743617

3743619

3743621

3743623

3743625

3743627

3743628

3743630

3743632

3743633

3743634

3743635

3743636

3743637

3743638

3743639

67540

8012150

A_33_P3608172

AAB60432

AAH13652

AAI03902

AAI03904

AAI07739

AAP35644

AC026954

AK301877

AL122080

AL157493

BAG63313

BC013652

BC103901

BC103903

BC107738

BT006998

CAB59255

CAB75677

CAG46524

CAG46550

CCDS11100

CR541723

CR541750

ENSG00000132522

ENSP00000370104

ENSP00000379841

ENST00000380728

ENST00000380728.6

ENST00000389167

ENST00000389167.9

EntrezGene:2874

EntrezGene:GPS2

g7018539_3p_s_at

GE85823

GO:0000122

GO:0000188

GO:0002376

GO:0003674

GO:0003713

GO:0003714

GO:0005095

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006464

GO:0006629

GO:0006810

GO:0006950

GO:0007165

GO:0007254

GO:0008150

GO:0009058

GO:0010804

GO:0010875

GO:0016032

GO:0017053

GO:0019216

GO:0030154

GO:0030183

GO:0030234

GO:0030332

GO:0032991

GO:0034122

GO:0034260

GO:0034641

GO:0035360

GO:0043226

GO:0044403

GO:0045598

GO:0045599

GO:0045944

GO:0046329

GO:0048856

GO:0050728

GO:0050859

GO:0098780

GO:1900045

GPS2

GPS2-201

GPS2-202

HGNC:4550

HPA067540

I3L1H4

I3L4X7

ILMN_1815158

IPR026094

MIM:601935

NM_004489

NP_004480

PF15991

U28963

U28963_at

UPI0000000DD1

Participant Of

hasComponent

input

Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene

Inferred To

Gps2 [nucleoplasm] (Mus musculus)

GPS2 [nucleoplasm] (Bos taurus)

GPS2 [nucleoplasm] (Canis familiaris)

GPS2 [nucleoplasm] (Danio rerio)

GPS2 [nucleoplasm] (Drosophila melanogaster)

GPS2 [nucleoplasm] (Rattus norvegicus)

GPS2 [nucleoplasm] (Sus scrofa)

GPS2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004480.1

OpenTargets

ENSG00000132522

GeneCards

Q13227

PRO

Q13227

PDB

2L5G

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15379 HDAC3	2	Unfolded HDAC3 [cytosol] (R-HSA-6813777) HDAC3 [nucleoplasm] (R-HSA-442464)	0.773	6
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.766	8
UniProt:P18848 ATF4	1	ATF4 [nucleoplasm] (R-HSA-381016)	0.764	9
UniProt:Q86VW0 SESD1			0.764	6
UniProt:P06463 VE6			0.729	6
UniProt:P06462 VE6			0.729	6
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.696	5
UniProt:O60907-2 TBL1X			0.656	6
UniProt:A0A024RBS3 A0A024RBS3			0.639	4
UniProt:P03122 VE2			0.593	5
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.527	2
UniProt:P06428 VE6			0.527	2
UniProt:P06929 VE6			0.527	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	2
UniProt:P03126 VE6			0.527	3
UniProt:P57077 M3KCL			0.508	2
UniProt:Q9WMX2-PRO_0000037551			0.508	2
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.499	2
UniProt:P12504 VIF			0.499	2
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.488	2
UniProt:O76013-2 KRT36			0.488	2
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.488	2
UniProt:Q5TA45 INTS11	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.488	2
UniProt:Q15038 DAZP2			0.488	2
UniProt:Q05BL1 Q05BL1			0.488	2
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.488	2
UniProt:Q9ULX6 AKP8L			0.488	2
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.488	2
IntAct:EBI-17198574 KRTAP63			0.488	2
UniProt:Q5TD97 FHL5			0.488	2
UniProt:P06921 VE2			0.488	2
UniProt:A8MQ03 CRTP1			0.488	2
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.488	2
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.488	2
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.488	2
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.488	2
UniProt:Q9H4R4 CT191			0.488	2
UniProt:Q5BKX5-3 C19ORF54			0.488	2
UniProt:Q15654 TRIP6			0.488	2
UniProt:Q8WUN7 UBTD2			0.488	2
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.488	2
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.488	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.488	2
UniProt:O95429 BAG4	3	BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.488	2
UniProt:Q9Y2D1 ATF5	1	ATF5 [nucleoplasm] (R-HSA-9653719)	0.488	2
UniProt:Q16633 OBF1			0.488	2
UniProt:Q53HV7-2 SMUG1			0.488	2
IntAct:EBI-12022818 PRR22			0.488	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.488	2
UniProt:A1KXE4-2 FAM168B			0.488	2