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p-T,Y MAPKs [cytosol]
Stable Identifier
R-HSA-169289
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by MAP2K mutants (Homo sapiens)
MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by LTK in cancer (Homo sapiens)
CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Homo sapiens)
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
Lyn activates ERK (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
PEA15 binds MAPK monomers and dimers (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs dimerize (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Negative feedback regulation of MAPK pathway (Homo sapiens)
Activated MAPK phosphorylates RAF1 (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Activated MAPKs phosphorylate BRAF (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
PEA15 binds MAPK monomers and dimers (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs dimerize (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
p-T,Y MAPKs dimerize (Homo sapiens)
p-T,Y MAPKs [cytosol] (Homo sapiens)
Participants
members
p-T202,Y204-MAPK3 [cytosol]
(Homo sapiens)
p-T185,Y187-MAPK1 [cytosol]
(Homo sapiens)
Participates
as an output of
Lyn activates ERK (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
as a component of
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
as an input of
p-T,Y MAPKs dimerize (Homo sapiens)
as a member of
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
Inferred To
p-T,Y MAPKs [cytosol]
(Bos taurus)
p-T,Y MAPKs [cytosol]
(Caenorhabditis elegans)
p-T,Y MAPKs [cytosol]
(Canis familiaris)
p-T,Y MAPKs [cytosol]
(Danio rerio)
p-T,Y MAPKs [cytosol]
(Dictyostelium discoideum)
p-T,Y MAPKs [cytosol]
(Drosophila melanogaster)
p-T,Y MAPKs [cytosol]
(Mus musculus)
p-T,Y MAPKs [cytosol]
(Plasmodium falciparum)
p-T,Y MAPKs [cytosol]
(Rattus norvegicus)
p-T,Y MAPKs [cytosol]
(Saccharomyces cerevisiae)
p-T,Y MAPKs [cytosol]
(Schizosaccharomyces pombe)
p-T,Y MAPKs [cytosol]
(Sus scrofa)
phospho-p-T185,Y187-MAPK1 [cytosol]
(Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol]
(Xenopus tropicalis)
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