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p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
Stable Identifier
R-HSA-444293
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho(S232,T368,S372,S389,T581,S742)-Ribosomal protein S6 kinase alpha 6, p-S232,T368,S372,S389,T581,S742-RSK4
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)
p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm] (Homo sapiens)
p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm] (Homo sapiens)
RSK activation (Homo sapiens)
p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)
p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm] (Homo sapiens)
p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UK32 RPS6KA6
Gene Names
RPS6KA6, RSK4
Chain
chain:1-745
Reference Genes
BioGPS Gene:27330 RPS6KA6
COSMIC (genes):RPS6KA6 RPS6KA6
CTD Gene:27330 RPS6KA6
dbSNP Gene:27330 RPS6KA6
ENSEMBL:ENSG00000072133 RPS6KA6
HGNC:10435 RPS6KA6
KEGG:hsa:27330 RPS6KA6
Monarch:27330 RPS6KA6
NCBI Gene:27330 RPS6KA6
OMIM:300303 RPS6KA6
UCSC:Q9UK32 RPS6KA6
Reference Transcript
RefSeq:NM_014496.4 RPS6KA6
RefSeq:NM_001330512.1 RPS6KA6
RefSeq:XM_011530917.2 RPS6KA6
Other Identifiers
11734272_a_at
17112439
220738_PM_s_at
220738_s_at
228502_PM_at
228502_at
228503_PM_at
228503_at
27330
4014026
4014028
4014030
4014031
4014032
4014033
4014034
4014037
4014038
4014039
4014041
4014042
4014043
4014044
4014045
4014046
4014049
4014050
4014051
4014052
4014053
4014057
4014058
4014059
4014060
4014061
4014062
4014064
4014066
4014067
4014068
4014069
4014070
4014071
50972_s_at
53658_at
77852_r_at
8173825
A_23_P125596
A_32_P424932
GE481984
GE81934
GE85049
GO:0000287
GO:0001650
GO:0003824
GO:0004672
GO:0004674
GO:0004711
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0006468
GO:0006978
GO:0007165
GO:0007417
GO:0016740
GO:0035556
GO:0043226
GO:0045992
GO:0046872
GO:0048856
GO:0070373
GO:0106310
GO:0140096
GO:2000381
HMNXSV003015599
Hs.234478.0.S1_3p_at
Hs.234478.0.S2_3p_at
ILMN_1807968
ILMN_1843157
PH_hs_0012792
PH_hs_0024060
TC0X001186.hg
TC0X002141.hg
g7657525_3p_at
Participates
as a candidate of
p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T368,S372,S389,T581,S742-RPS6KA6 [cytosol]
p-S232,T368,S372,S389,T581,S742-RPS6KA6 [cytosol]
p-T368,S372,T581-RPS6KA6 [cytosol]
RPS6KA6 [cytosol]
Inferred To
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Bos taurus)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Gallus gallus)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Mus musculus)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Sus scrofa)
phospho-p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(Xenopus tropicalis)
phospho-RPS6KA6 [nucleoplasm]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-serine at 232
Coordinate
232
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 368
Coordinate
368
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 372
Coordinate
372
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 389
Coordinate
389
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 581
Coordinate
581
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 742
Coordinate
742
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_011529219.1
,
NP_001317441.1
,
NP_055311.1
ZINC - World Drugs
KS6A6_HUMAN
Guide to Pharmacology - Targets
1530
OpenTargets
ENSG00000072133
ENSEMBL
ENST00000262752
,
ENSP00000483896
,
ENSP00000262752
,
ENST00000620340
ZINC - FDA approved
KS6A6_HUMAN
ZINC - Substances
KS6A6_HUMAN
ZINC - Biogenic
KS6A6_HUMAN
ZINC target
Q9UK32
PRO
Q9UK32
GlyGen
Q9UK32
PDB
6G78
,
6G77
,
6G76
ZINC - Investigational
KS6A6_HUMAN
HPA
ENSG00000072133-RPS6KA6
Pharos - Targets
Q9UK32
ZINC - Predictions - Purchasable
KS6A6_HUMAN
HMDB Protein
HMDBP01377
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.547
2
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