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K48PolyUb-KDM4B [nucleoplasm]
Stable Identifier
R-HSA-5683074
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
K48PolyUb-JMJD2B
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
K48PolyUb-KDM4A,B [nucleoplasm] (Homo sapiens)
K48PolyUb-KDM4B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94953 KDM4B
Gene Names
KDM4B, JHDM3B, JMJD2B, KIAA0876
Chain
chain:1-1096
Reference Genes
BioGPS Gene:23030 KDM4B
COSMIC (genes):KDM4B KDM4B
CTD Gene:23030 KDM4B
dbSNP Gene:23030 KDM4B
ENSEMBL:ENSG00000127663 KDM4B
HGNC:29136 KDM4B
KEGG:hsa:23030 KDM4B
Monarch:23030 KDM4B
NCBI Gene:23030 KDM4B
OMIM:609765 KDM4B
UCSC:O94953 KDM4B
Reference Transcript
RefSeq:NM_001370093.1 KDM4B
RefSeq:NM_015015.2 KDM4B
Other Identifiers
11743512_x_at
11747909_x_at
11755420_a_at
11761992_at
1559073_PM_at
1559073_at
16857282
212492_PM_s_at
212492_s_at
212495_PM_at
212495_at
212496_PM_s_at
212496_s_at
215616_3p_s_at
215616_PM_s_at
215616_s_at
216023_PM_at
216023_at
23030
240780_PM_at
240780_at
33226_at
3817734
3817741
3817751
3817752
3817754
3817755
3817756
3817757
3817758
3817759
3817760
3817761
3817763
3817775
3817776
3817777
3817778
3817779
3817780
3817781
3817782
3817784
3817785
3817800
3817801
3817802
3817803
3817804
3817807
3817808
3817809
3817811
3817812
3817813
3817814
3817815
3817817
3817818
3817819
3817820
3817821
3817822
3817823
3817825
3817826
3817827
3817828
3817829
3817830
3817834
3817835
3817837
3817842
3817844
3817845
3817846
58501_at
68886_r_at
79679_at
8024909
A_14_P125389
A_24_P932648
A_33_P3254101
A_33_P3319920
A_33_P3396600
GE509887
GE53555
GO:0000785
GO:0003824
GO:0005634
GO:0005654
GO:0005721
GO:0005829
GO:0006325
GO:0006338
GO:0007420
GO:0008270
GO:0010468
GO:0016491
GO:0032452
GO:0032454
GO:0043226
GO:0048856
GO:0051213
GO:0051864
GO:0140096
GO:0140684
HMNXSV003020264
HMNXSV003045804
Hs.197314.0.A1_3p_at
Hs.301011.0.S1_3p_a_at
Hs.301011.0.S2_3p_at
Hs.301011.2.S1_3p_x_at
Hs.306827.0.S1_3p_at
Hs2.157862.1.A1_3p_at
ILMN_1720531
PH_hs_0015500
TC19000099.hg
TC19000100.hg
Participates
as a member of
K48PolyUb-KDM4A,B [nucleoplasm] (Homo sapiens)
Other forms of this molecule
KDM4B [nucleoplasm]
Inferred To
RPH1 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of K48PolyUb-KDM4B [nucleoplasm]
(Drosophila melanogaster)
Homologues of K48PolyUb-KDM4B [nucleoplasm]
(Saccharomyces cerevisiae)
Kdm4A [nucleoplasm]
(Drosophila melanogaster)
GIS1 [nucleoplasm]
(Saccharomyces cerevisiae)
Kdm4B [nucleoplasm]
(Drosophila melanogaster)
Kdm4b [nucleoplasm]
(Mus musculus)
Kdm4b [nucleoplasm]
(Rattus norvegicus)
KDM4B [nucleoplasm]
(Bos taurus)
KDM4B [nucleoplasm]
(Canis familiaris)
KDM4B [nucleoplasm]
(Gallus gallus)
KDM4B [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [nucleoplasm]) at unknown position
Modification
K48polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001357022.1
,
NP_055830.1
Guide to Pharmacology - Targets
2676
ENSEMBL
ENST00000381759
,
ENSP00000371178
,
ENSG00000127663
OpenTargets
ENSG00000127663
ZINC - Substances
KDM4B_HUMAN
ZINC target
O94953
PRO
O94953
GlyGen
O94953
PDB
7JM5
,
9H44
,
4UC4
,
4LXL
IntEnz
1.14.11.66
GeneCards
KDM4B
HPA
ENSG00000127663-KDM4B
Pharos - Targets
O94953
ZINC - Predictions - Purchasable
KDM4B_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.527
3
UniProt:P78371 CCT2
3
CCT2 [cytosol]
(R-HSA-390464)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
0.527
3
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
2
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