Reactome | K48PolyUb-KDM4B [nucleoplasm]

K48PolyUb-KDM4B [nucleoplasm]

Stable Identifier

R-HSA-5683074

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

K48PolyUb-JMJD2B

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
        
        K48PolyUb-KDM4A,B [nucleoplasm] (Homo sapiens)
        
        K48PolyUb-KDM4B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94953 KDM4B

Gene Names

KDM4B, JHDM3B, JMJD2B, KIAA0876

Chain

chain:1-1096

Reference Genes

BioGPS Gene:23030 KDM4B

COSMIC (genes):KDM4B KDM4B

CTD Gene:23030 KDM4B

dbSNP Gene:23030 KDM4B

ENSEMBL:ENSG00000127663 KDM4B

HGNC:29136 KDM4B

KEGG Gene (Homo sapiens):23030 KDM4B

Monarch:23030 KDM4B

NCBI Gene:23030 KDM4B

OMIM:609765 KDM4B

UCSC:O94953 KDM4B

Reference Transcript

RefSeq:NM_015015.2 KDM4B

Other Identifiers

11761992_at

23030

3817734

3817741

3817751

3817752

3817754

3817755

3817756

3817763

3817776

3817780

3817784

3817800

3817801

3817802

3817803

3817804

A_33_P3254101

A_33_P3396600

GE509887

GO:0003674

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006259

GO:0006302

GO:0006325

GO:0006338

GO:0006464

GO:0006950

GO:0008150

GO:0016491

GO:0032452

GO:0032454

GO:0033169

GO:0034641

GO:0043167

GO:0043226

GO:0046872

GO:0051213

GO:0051276

GO:0051864

GO:0070544

HMNXSV003020264

TC19000100.hg

Participates

as a member of

K48PolyUb-KDM4A,B [nucleoplasm] (Homo sapiens)

Other forms of this molecule

KDM4B [nucleoplasm]

Inferred To

RPH1 [nucleoplasm] (Saccharomyces cerevisiae)

jmj3 [nucleoplasm] (Schizosaccharomyces pombe)

kdm4b [nucleoplasm] (Danio rerio)

Kdm4b [nucleoplasm] (Mus musculus)

Kdm4b [nucleoplasm] (Rattus norvegicus)

KDM4B [nucleoplasm] (Canis familiaris)

KDM4B [nucleoplasm] (Gallus gallus)

KDM4B [nucleoplasm] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [nucleoplasm]) at unknown position

Modification

K48polyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_055830.1

Guide to Pharmacology - Targets

2676

OpenTargets

ENSG00000127663

HPA

ENSG00000127663-KDM4B

ZINC - Substances

KDM4B_HUMAN

GeneCards

O94953

ZINC target

O94953

Ensembl

ENSP00000371178, ENST00000381759, ENSG00000127663

PRO

O94953

Pharos - Targets

O94953

ZINC - Predictions - Purchasable

KDM4B_HUMAN

PDB

4UC4, 4LXL

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