Reactome | ATG16L1 [cytosol]

ATG16L1 [cytosol]

Stable Identifier

R-HSA-5671734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Autophagy-related protein 16-1, A16L1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q676U5 ATG16L1

Gene Names

ATG16L1, APG16L, UNQ9393/PRO34307

Chain

chain:1-607

Reference Genes

BioGPS Gene:55054 ATG16L1

COSMIC (genes):ATG16L1 ATG16L1

CTD Gene:55054 ATG16L1

dbSNP Gene:55054 ATG16L1

ENSEMBL:ENSG00000085978 ATG16L1

HGNC:21498 ATG16L1

KEGG:hsa:55054 ATG16L1

Monarch:55054 ATG16L1

NCBI Gene:55054 ATG16L1

OMIM:610767 ATG16L1

UCSC:Q676U5 ATG16L1

Reference Transcript

Participates

as an input of

ATG5:ATG12 binds ATG16L1 (Homo sapiens)

as a component of

ATG16L1 complex [cytosol] (Homo sapiens)

Inferred To

atg-16.2 [cytosol] (Caenorhabditis elegans)

tipD [cytosol] (Dictyostelium discoideum)

Atg16 [cytosol] (Drosophila melanogaster)

atg16 [cytosol] (Xenopus tropicalis)

Ghost homologue of ATG16L1 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of ATG16L1 [cytosol] (Schizosaccharomyces pombe)

ATG16L1 [cytosol] (Bos taurus)

ATG16L1 [cytosol] (Canis familiaris)

ATG16L1 [cytosol] (Gallus gallus)

ATG16L1 [cytosol] (Sus scrofa)

Atg16l1 [cytosol] (Mus musculus)

Atg16l1 [cytosol] (Rattus norvegicus)

Homologues of ATG16L1 [cytosol] (Caenorhabditis elegans)

atg-16.1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001177195.1, NP_110430.5, NP_001177196.1, NP_060444.3, NP_942593.2

OpenTargets

ENSG00000085978

ENSEMBL

ENST00000630066, ENSP00000362625, ENSG00000281089, ENSP00000318259, ENST00000373525, ENST00000392017, ENST00000347464, ENST00000392020, ENSG00000085978, ENST00000630204, ENSP00000375872, ENSP00000375875, ENSP00000487298, ENSP00000487446, ENSP00000487455, ENSP00000487542, ENST00000625501, ENST00000626623

HPA

ENSG00000085978-ATG16L1

GeneCards

ATG16L1

PRO

Q676U5

Pharos - Targets

Q676U5

PDB

5NPV, 5D7G, 7XFR, 4GDL, 5NPW, 4TQ0, 4GDK, 5ZYX, 7W36, 5NUV, 4NAW, 7F69

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.8	11
UniProt:Q8TDY2 RB1CC1	3	RB1CC1 [endoplasmic reticulum membrane] (R-HSA-8948046) p-RB1CC1 [cytosol] (R-HSA-5675845) RB1CC1 [cytosol] (R-HSA-5333627)	0.748	6
UniProt:O94817 ATG12	2	ATG12 [phagocytic vesicle membrane] (R-HSA-5205625) ATG12 [cytosol] (R-HSA-936011)	0.744	4
UniProt:Q9H082 RAB33B	4	GGC-RAB33B [Golgi membrane] (R-HSA-6810968) RAB33B [Golgi membrane] (R-HSA-8854609) GGC-RAB33B [cytosol] (R-HSA-8874107) RAB33B [cytosol] (R-HSA-8873702)	0.666	5
UniProt:Q14088 RAB33A	3	RAB33A [Golgi membrane] (R-HSA-8854592) GGC-RAB33A [cytosol] (R-HSA-8873981) RAB33A [cytosol] (R-HSA-8873704)	0.666	5
UniProt:Q9NT62 ATG3	8	CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) ATG3 [cytosol] (R-HSA-5671860)	0.643	3
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.564	2
UniProt:Q9BXS4 TMEM59	1	TMEM59 [plasma membrane] (R-HSA-9714669)	0.544	6
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.527	3
UniProt:O75143 ATG13	3	p-ATG13 [endoplasmic reticulum membrane] (R-HSA-8948049) p-ATG13 [cytosol] (R-HSA-5675831) ATG13 [cytosol] (R-HSA-5333624)	0.527	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.525	2
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [cytosol] (R-HSA-5679223) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [autophagosome membrane] (R-HSA-5683638)	0.525	4
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.525	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.483	2

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