Reactome | KDM4B [nucleoplasm]

KDM4B [nucleoplasm]

Stable Identifier

R-HSA-3214396

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lysine-specific demethylase 4B, KDM4B_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - ATM phosphorylates HERC2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - KDM4A,B bind H4K20Me2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - RNF168 binds DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94953 KDM4B

Gene Names

KDM4B, JHDM3B, JMJD2B, KIAA0876

Chain

chain:1-1096

Reference Genes

BioGPS Gene:23030 KDM4B

COSMIC (genes):KDM4B KDM4B

CTD Gene:23030 KDM4B

dbSNP Gene:23030 KDM4B

ENSEMBL:ENSG00000127663 KDM4B

HGNC:29136 KDM4B

KEGG Gene (Homo sapiens):23030 KDM4B

Monarch:23030 KDM4B

NCBI Gene:23030 KDM4B

OMIM:609765 KDM4B

UCSC:O94953 KDM4B

Reference Transcript

RefSeq:NM_015015.2 KDM4B

Other Identifiers

11761992_at

23030

3817734

3817741

3817751

3817752

3817754

3817755

3817756

3817763

3817776

3817780

3817784

3817800

3817801

3817802

3817803

3817804

A0A0C4DFL8

A_33_P3254101

A_33_P3396600

ENSG00000127663

ENSP00000371178

ENST00000381759

ENST00000381759.8

EntrezGene:23030

EntrezGene:KDM4B

F5GX28

GE509887

GO:0003674

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0006464

GO:0008150

GO:0016491

GO:0032452

GO:0032454

GO:0032991

GO:0033169

GO:0035097

GO:0043167

GO:0043226

GO:0046872

GO:0051213

GO:0051276

GO:0051864

GO:0055114

GO:0070544

HGNC:29136

IPR003347

IPR003349

K7ES23

KDM4B

KDM4B-202

MIM:609765

NM_001370093

NM_001370094

NP_001357022

NP_001357023

PF02373

PF02375

SM00545

SM00558

TC19000100.hg

UPI0000227E7B

XM_011527819

XM_011527820

XM_011527821

XM_011527822

XM_017026504

XM_017026505

XP_011526121

XP_011526122

XP_011526123

XP_011526124

XP_016881993

XP_016881994

Participant Of

output

input

ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers

hasComponent

KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm]

hasMember

Other forms of this molecule

K48PolyUb-KDM4B [nucleoplasm]

Inferred To

KDM4B [nucleoplasm] (Bos taurus)

KDM4B [nucleoplasm] (Canis familiaris)

KDM4B [nucleoplasm] (Danio rerio)

KDM4B [nucleoplasm] (Gallus gallus)

KDM4B [nucleoplasm] (Mus musculus)

KDM4B [nucleoplasm] (Rattus norvegicus)

KDM4B [nucleoplasm] (Schizosaccharomyces pombe)

KDM4B [nucleoplasm] (Sus scrofa)

KDM4B [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_055830.1

OpenTargets

ENSG00000127663

ZINC - Substances

KDM4B_HUMAN

GeneCards

O94953

ZINC target

O94953

PRO

O94953

ZINC - Predictions - Purchasable

KDM4B_HUMAN

PDB

4UC4, 4LXL